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anti-Mouse (Murine) PSME3 Antikörper:
anti-Rat (Rattus) PSME3 Antikörper:
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the ubiquitin-independent REGgamma proteasome regulates energy homeostasis
Study demonstrated that Psme3/Psme4 (zeige PSME4 Antikörper) double KO (dKO) male mice are completely infertile and showed the up-regulation of several proteins involved in oxidative stress response in dKO sperms. These results suggest the important role of PA28gamma and PA200 (zeige PSME4 Antikörper) in male fertility.
Findings reveal a novel regulatory pathway in which the REGgamma-proteasome controls the steady-state level of GSK3beta protein.
PSME3 is a target gene of NF-kappaB (zeige NFKB1 Antikörper) during bacterial infections. PSME3 activates NF-kappaB (zeige NFKB1 Antikörper) by degrading KLF2 (zeige KLF2 Antikörper).
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
REGgamma acts in skin tumorigenesis mediating MAPK/p38 (zeige MAPK1 Antikörper) activation of the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway.
In a p53 (zeige TP53 Antikörper)-dominated cellular context, pro-apoptotic signaling might be overcome by PA28gamma-mediated caspase (zeige CASP3 Antikörper) inhibition.
Data suggest levels of gene expression of both Psme3 (proteasome activator subunit 3) and Dusp3 (dual specificity phosphatase 3 (zeige DUSP3 Antikörper)) are associated with susceptibility to Staphylococcus aureus infection/sepsis in humans and in mouse disease model.
PKA turnover by the REGgamma-proteasome modulates FoxO1 (zeige FOXO1 Antikörper) cellular activity and VEGF (zeige VEGFA Antikörper)-induced angiogenesis.
REGgamma binds to SirT1 (zeige SIRT1 Antikörper), promotes its Ub-independent degradation, and inhibits its activity to deacetylate autophagy-related proteins, thereby inhibiting autophagy under normal conditions.
Knockdown of REG-GAMMA (REGgamma) may inhibit the proliferation and migration, and promote the apoptosis of plasma cell myeloma RPMI-8226 cells possibly by downregulating NF-kappa-B (NF-kappaB (zeige NFKB1 Antikörper)) signal pathway.
data show that PIP30 deeply affects PA28gamma interactions with cellular proteins, including the 20S proteasome (zeige PSMA5 Antikörper), demonstrating that it is an important regulator of PA28gamma in cells and thus a new player in the control of the multiple functions of the proteasome within the nucleus.
This study demonstrates that REGgamma is a central molecule in the development of melanoma by regulating Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway.
that Proteasome activator subunit 3 induces epithelial-mesenchymal transition with inducing the expression of CSC markers and influencing the tumor immune microenvironment in breast cancer
PSME3 plays an oncogenic role in pancreatic cancer by inhibiting c-Myc (zeige MYC Antikörper) degradation to promote glycolysis.
Study demonstrated that the gene therapy with proteasome activator, PA28gamma can improve ubiquitin-proteasome system function as well as behavioral abnormalities in Huntington's disease model mice
Surrogate Prognostic Biomarkers in OSCC: The Paradigm of PA28gamma Overexpression.
PA28gamma in OSCC tumor tissues were significantly high expression than those in normal tissues.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants.
11S regulator complex subunit gamma
, activator of multicatalytic protease subunit 3
, ki nuclear autoantigen
, proteaseome (prosome, macropain) 28 subunit, 3
, proteasome activator 28 subunit gamma
, proteasome activator complex subunit 3
, 11S regulator complex gamma subunit
, Ki antigen
, Ki nuclear autoantigen
, PA28 gamma variant 5
, proteasome activator 28-gamma
, proteasome activator subunit 3