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SNP rs17336700 of a non-MHC (zeige HLAE Antikörper) ubiquitin-proteasome subunit PSMD7 is significantly associated with ankylosing spondylitis in Chinese population and the mRNA level of the PSMD7 gene in liver tissue increased when the rs17336700 C allele was present.
hVIP (zeige COPS6 Antikörper) is a member of the complex array of nucleocytoplasmic shuttling proteins that are regulated by HIV infection and glucocorticoids
data suggest a differential nuclear function of modified and unmodified S12 (zeige HTR1B Antikörper) in cancer
MPN (zeige PRSS27 Antikörper) domain of Mov34 is highly resistant to proteolysis
although the MPN domain of Mov34 shows a typical metalloprotease fold, it is unable to coordinate a metal ion.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.
26S proteasome non-ATPase regulatory subunit 7
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)
, 26s proteasome regulatory subunit s12
, 26S proteasome regulatory subunit S12
, Mov34 domain-containing protein
, 26S proteasome regulatory subunit rpn8
, Moloney leukemia virus-34 proviral integration
, Mov34 homolog
, proteasome subunit p40
, 26S proteasome regulatory subunit RPN8
, proteasome 26S non-ATPase subunit 7