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overexpression of RPN11 in breast cancer tissues was associated with an advanced clinical stage. Patients with tumors with high expression of RPN11 had worse prognosis.
Deubiquitylase POH1 stabilizes E2F1 protein through binding (zeige E2F1 Proteine)to and deubiquitylating E2F1 in liver cancer.
The data demonstrated that proteasomal POH1 is a key de-ubiquitinating enzyme that regulates ubiquitin conjugates generated in response to damage and that several aspects of the DNA double-strand break response are regulated by the proteasome.
Disorder of POH1 expression is involved in the onset of idiopathic nephrotic syndrome (INS (zeige INS Proteine)), and confers multidrug resistance in children with INS (zeige INS Proteine)
Down-regulation of PSMD14 results in decreased cell proliferation, cell cycle arrest and senescence. A comparative study with PSMB5 (zeige PSMB5 Proteine), revealed that PSMB5 (zeige PSMB5 Proteine) and PSMD14 have different effects on cell cycle, senescence and associated molecular events.
Ectopic expression of POH1 in HEK293 cells decreased the level of c-Jun (zeige JUN Proteine) ubiquitination, leading to significant accumulation of the protein and a corresponding increase in AP1 (zeige FOSB Proteine)-mediated gene expression
An intact zinc metalloproteinase motif of Poh1 is essential for cell viability and 26S proteasome (zeige Psmd4 Proteine) function.
Specificity for K63-linked polyubiquitin (zeige UBB Proteine) is a common property of the JAMM/MPN (zeige PRSS27 Proteine)+ family of deubiquitinating enzymes.
Conditional knockout of Poh1 alleles results in reduced E2F1 (zeige E2F1 Proteine) expression in primary mouse liver cells.
These results identify a novel mechanism of Mitf (zeige MITF Proteine) regulation in osteoclasts by POH1.
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2.
26S proteasome non-ATPase regulatory subunit 14
, 26S proteasome regulatory subunit rpn11
, 26S proteasome-associated PAD1 homolog 1
, 26S proteasome non-ATPase subunit
, 26S proteasome-associated pad1 homolog
, proteasome 26S subunit, non-ATPase 14
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 14