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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.
26S proteasome non-ATPase regulatory subunit 1 , 26S proteasome regulatory subunit RPN2 , 26S proteasome regulatory subunit S1 , 26S proteasome subunit p112 , 26S proteasome p112 subunit , 26S proteasome, subunit p112 , proteasome 26S non-ATPase subunit 1 , proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 , proteasome 26S subunit, non-ATPase 1 L homeolog
GENE ID | SPEZIES |
---|---|
5707 | Homo sapiens |
70247 | Mus musculus |
83806 | Rattus norvegicus |
424926 | Gallus gallus |
554967 | Danio rerio |
511803 | Bos taurus |
100736234 | Cavia porcellus |
101122259 | Ovis aries |
100057015 | Equus caballus |
100683530 | Canis lupus familiaris |
100153828 | Sus scrofa |
446265 | Xenopus laevis |