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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
26S protease regulatory subunit 6B
, 26S protease regulatory subunit 6b
, 26S proteasome subunit ATPase 4
, HIV TAT binding-protein-related
, 26S proteasome regulatory complex ATPase RPT3
, 26S proteasome AAA-ATPase subunit RPT3
, MB67-interacting protein
, Tat-binding protein 7
, protease 26S subunit 6
, CAR interacing protein 21
, CAR interacting protein 21
, TAT-binding protein 7
, proteasome 26S ATPase subunit 4
, proteasome 26S subunit ATPase 4
, S6 ATPase