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Although treatment with IFN-gamma (zeige IFNG Proteine) strongly induced the activation of STAT1 (zeige STAT1 Proteine) as a transcriptional activator, its target molecule, IRF1 (zeige IRF1 Proteine), was not clearly produced in Lmp2-deficient uterine smooth muscle cells.
down-regulation of IL-33 (zeige IL33 Proteine) protein levels by IFN-gamma (zeige IFNG Proteine) in pulmonary fibroblasts and in the lungs in vivo occurs through STAT1 (zeige STAT1 Proteine) and non-canonical use of the LMP2 proteasome
Data show that knockdown of i-proteasome catalytic subunit PSMB9 by short hairpin RNA (shRNA) decreased the expression of both PSMB9 and PSMB8 (zeige PSMB8 Proteine) without affecting other catalytic subunits of the proteasome.
LMP2 has a role as a tumor-suppressor and may have a role in uterine leiomyosarcoma therapy
In this study, we have identified how LMP2 can exert its function in Ag processing
Mixed proteasomes present in LMP2-deficient mice compromise virtually every parameter of the immune response against influenza A virus, potentially through dysregulation of signaling pathways, such as the nuclear factor (NF)-kappaB (zeige NFKB1 Proteine) pathway.
Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice.
Comparison of LMP2 KO mice and non-transgenic mice of the same background show that LMP2 KO mice exhibit a higher degree of motor function, but possess a similar level of cognitive function and ambulation.
Immunoproteasome LMP2 can at least in part determine subdominance and shape the epitope hierarchy of cytotoxic T cell responses in vivo.
Immunoproteasome LMP2 may affect CD8 (zeige CD8A Proteine)+ T cell responses to only a limited number of viral epitopes; its main biological function may lie elsewhere.
single nucleotide polymorphism in PSMB9 are associated with hand dermatitis
Data show that tight junction protein 1 (TJP1 (zeige TJP1 Proteine)) suppressed expression of the catalytically proteasome subunits LMP7 (zeige PSMB8 Proteine) and LMP2, decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo through suppression of EGFR (zeige EGFR Proteine)/JAK1 (zeige JAK1 Proteine)/STAT3 (zeige STAT3 Proteine) signaling.
Chinese females carrying the rs17587-G/G genotype in PSMB9 may increase a higher risk for Parkinson's disease.
designed siRNAs that efficiently silence LMP2, LMP7 (zeige PSMB8 Proteine) and MECL-1 (zeige PSMB10 Proteine) gene expression.
The TAP1 (zeige TAP1 Proteine)-rs1135216 and PSMB9-rs17587 variants are significantly associated with vitiligo (zeige MITF Proteine), and even one copy of these mutant alleles can influence the risk among Saudis.
Comparison with reference profiles of sorted immune cells and healthy muscle confirmed upregulation of PSMB8 (zeige PSMB8 Proteine) and -9 in myositis biopsies beyond infiltration related changes.
study found prevalence of LMP2-AA genotype was higher in acute myeolid leukemia (AML (zeige RUNX1 Proteine)) patients while it was significantly lower in multiple myeloma (MM) cases than in the control subjects; results suggestLMP2 polymorphisms could play a role in the development of AML (zeige RUNX1 Proteine) and MM
Data indicate that the codon 60 Arg/His polymorphism does not significantly alter the expression and activity of beta1i among the cell lines tested and clinical samples from colon and pancreatic cancer.
The data show that LMP2 and PSMA6 (zeige PSMA6 Proteine) gene polymorphism is not a risk factor of ischemic stroke in Ukrainian population.
functional variants in PSMB9 may contribute to melanoma susceptibility.
These results suggest LMP2/LMP7 (zeige PSMB8 Proteine) gene should be regarded as molecular marker to estimate animal's immune status for their effects on hematological traits.
LMP2 is involved in antigen presentation and is an important candidate gene for initial exploration of relationships between antigen processing genes and disease resistance.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
, proteasome beta subunit
, proteasome beta 9 subunit
, Low molecular mass protein 2
, proteasome subunit beta type-9
, proteasome subunit, beta type 9
, proteasome subunit beta type-9b
, low molecular mass protein 2b
, large multifunctional protease 2
, low molecular mass protein 2
, macropain chain 7
, multicatalytic endopeptidase complex chain 7
, proteasome chain 7
, proteasome subunit beta-1i
, proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
, proteosome beta 9 subunit
, really interesting new gene 12 protein
, large multifunctional peptidase 2
, proteasome catalytic subunit 1i
, proteasome subunit beta 6i
, proteasome-related gene 2
, proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)
, RING12 protein
, low molecular mass polypeptide 2
, proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
, proteosome (prosome, macropain) subunit, beta type 9
, proteasome subunit, beta type 9 (large multifuntional protease 2)
, proteasome (prosome, macropain) subunit, beta type, 9a
, Proteasome subunit beta type-9
, low molecular mass polypeptide complex subunit 2