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Data demonstrate that TNF-alpha expression is primarily dependent on both the chymotrypsin-and the trypsin-like activities of X, Y, Z subunits (PSMB5, PSMB6, PSMB7) of the proteasome.
Studied the associations of Protein Z (PROZ G79A) and Endothelin-1 (EDN1 G5665T) polymorphisms with the clinical features of sickle cell disease (SCD) in a cohort of Egyptian children with SCD.
reduced protein levels in patients with rheumatoid arthritis in association with disease progression
high PSMB7 expression is associated with anthracycline resistance in breast cancer.
Low protein Z levels but not protein Z gene G79A polymorphism are a risk factor for ischemic stroke.
A previously unreported sporadic missense mutation within exon 8 is described in a patient with very low protein Z levels.
PSB7, PRDX1, and SRP9 up-regulation as candidate biomarkers of colon cancer is discovered
ZPI functions like other serpins to regulate the activity of FXa but in a manner uniquely dependent on protein Z, procoagulant membranes, and pH
we have identified and characterized a new phosphorylated isoform of the human 20S proteasome b7 subunit and showed its differential expression in tumor vs. normal cell lines
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14.
proteasome subunit beta type 7
, proteasome subunit beta type-7
, proteasome beta 7 subunit
, proteasome subunit beta type-7 proprotein
, proteasome (prosome, macropain) subunit, beta type, 7
, proteasome z subunit-like protein
, macropain chain Z
, multicatalytic endopeptidase complex chain Z
, proteasome subunit Z
, proteasome catalytic subunit 2
, proteasome subunit alpha
, beta-type proteasome 7 subunit