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Study found that PKMYT1 was essential for the proliferation and mobility of CRC (zeige CALR Proteine) cells in vitro. Also, results demonstrated that patients expressing high level of PKMYT1 displayed a worse overall survival rate than those with a low level of PKMYT1. These data indicated that PKMYT1 was a biomarker for the prediction of the prognosis of the disease.
PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition of hepatocellular carcinoma cells
Myt1 (zeige MYT1 Proteine) is inactivated by MEK1 (zeige MAP2K1 Proteine) mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis.
MYT1 (zeige MYT1 Proteine) binds to TSAP6 (zeige STEAP3 Proteine) in tumor cells and has a role in cell cycle regulation
Myt1 is phosphorylated by polo-like kinase 1
the induction of Cdc2 (zeige CDK1 Proteine) phosphorylation due to the increase of Wee1 (zeige WEE1 Proteine) and Myt1 (zeige MYT1 Proteine) as well as the reduction of Cdc2 (zeige CDK1 Proteine) and cyclin B1 (zeige CCNB1 Proteine) are involved in 1,25[OH]2VD3-induced G2/M arrest of keratinocytes.
The results show that Myt1 (zeige MYT1 Proteine)-mediated suppression of Cdc2 (zeige CDK1 Proteine) activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis in Hela cells.
Data show that CDK1 (zeige CDK1 Proteine) and cyclin B synergize during oocyte maturation to inhibit Myt1 ensuring meiotic progression.
Study propose a model in which the appearance of active MPF (zeige MSLN Proteine) complexes following increased Cyclin B synthesis causes Myt1 inhibition, upstream of the MPF (zeige MSLN Proteine)/Cdc25 (zeige CDC25C Proteine) amplification loop.
Autophosphorylation of Myt1 is a novel inhibitory mechanism that adds another layer of complexity to the phosphorylation-dependent mechanism of Myt1 regulation.
XRINGO-activated CDKs can phosphorylate specific residues in the regulatory domain of Myt1.
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
, protein kinase Myt1
, protein kinase, membrane associated tyrosine/threonine 1
, membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase-like
, myt1 kinase
, MYT1 kinase
, membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase