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interplay between MATalpha1, c-Myc (zeige MYC Proteine), and Maf (zeige MAF Proteine) proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis
Of the 22 single nucleotide polymorphisms studied, the rs8193 polymorphism lying in the micro-RNA binding site of 3'-UTR of CD44 (zeige CD44 Proteine) was significantly (P=.0270) associated with RT-induced adverse skin reactions. Generalized multifactor dimensionality reduction analysis showed significant (P=.0107) gene-gene interactions between MAT1A and CD44 (zeige CD44 Proteine).
A compound mutation of the methionine adenosyltransferase 1A (MAT1A) gene, c.345delA and c.529C>T, was identified in the patient, and His father and mother were found to be heterozygous for the c.345delA mutation and c.529C>T mutation, respectively.
S-adenosyl-L-methionine (zeige AS3MT Proteine) diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes.
5-Aza-CdR (zeige RUNX1T1 Proteine) showed no effects on MAT2A (zeige MAT2A Proteine) methylation.
The mutations in the other 10 patients showed autosomal recessive inheritance and included eight novel MAT1A mutations.
Liver-specific isoenzyme MAT1A is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A (zeige MAT2A Proteine), whose enzymatic activity is regulated by an associated subunit MAT2B (zeige MAT2B Proteine).
Methionine adenosyltransferase I/III deficiency is caused by mutations in the MAT1A gene. (Review)
upregulation of miR (zeige MLXIP Proteine)-664, miR (zeige MLXIP Proteine)-485-3p, and miR (zeige MLXIP Proteine)-495 contributes to lower MAT1A expression in HCC (zeige FAM126A Proteine), and enhanced tumorigenesis may provide potential targets for HCC (zeige FAM126A Proteine) therapy.
Report SNPs that are highly associated with hepatic GNMT (zeige GNMT Proteine) protein expression and the coordinate regulation of MAT1A levels.
MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD development in MAT1A-KO mice.
Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
DUSP1 (zeige DUSP1 Proteine) mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.
investigated the function of the Cdk7 (zeige CDK7 Proteine).cyclin (zeige PCNA Proteine) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A
MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor (zeige HGF Proteine). MAT1A-produced SAMe has a major role in ERK (zeige EPHB2 Proteine) signaling & cyclin D1 (zeige CCND1 Proteine) regulation during liver regeneration & mitogenic signal response.
Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo.
C/EBPbeta (zeige CEBPB Proteine) plays an important role in epigenetic regulation of the mature hepatic gene MAT1A
By 1 month of age, genomic instability increases in livers of Mat1a knockout mice, possibly due to reduced APEX1 (zeige APEX1 Proteine) levels
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
, S-adenosylmethionine synthase isoform type-1
, S-adenosylmethionine synthetase isoform type-1
, adoMet synthase 1
, adoMet synthetase 1
, methionine adenosyltransferase 1
, methionine adenosyltransferase I/III
, CDK-activating kinase assembly factor MAT1
, CDK7/cyclin H assembly factor
, CDK7/cyclin-H assembly factor
, RING finger protein MAT1
, S - adenosylmethionine synthetase