anti-Methionine Adenosyltransferase I, alpha (MAT1A) Antikörper

Human Methionine Adenosyltransferase I, alpha (MAT1A) Interaktionspartner

1. interplay between MATalpha1, c-Myc (zeige MYC Antikörper), and Maf (zeige MAF Antikörper) proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis

2. Of the 22 single nucleotide polymorphisms studied, the rs8193 polymorphism lying in the micro-RNA binding site of 3'-UTR (zeige UTS2R Antikörper) of CD44 (zeige CD44 Antikörper) was significantly (P=.0270) associated with RT-induced adverse skin reactions. Generalized multifactor dimensionality reduction analysis showed significant (P=.0107) gene-gene interactions between MAT1A and CD44 (zeige CD44 Antikörper).

3. A compound mutation of the methionine adenosyltransferase 1A (MAT1A) gene, c.345delA and c.529C>T, was identified in the patient, and His father and mother were found to be heterozygous for the c.345delA mutation and c.529C>T mutation, respectively.

4. S-adenosyl-L-methionine (zeige AS3MT Antikörper) diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes.

5. 5-Aza-CdR (zeige RUNX1T1 Antikörper) showed no effects on MAT2A (zeige MAT2A Antikörper) methylation.

6. The mutations in the other 10 patients showed autosomal recessive inheritance and included eight novel MAT1A mutations.

7. Liver-specific isoenzyme MAT1A is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A (zeige MAT2A Antikörper), whose enzymatic activity is regulated by an associated subunit MAT2B (zeige MAT2B Antikörper).

8. Methionine adenosyltransferase I/III deficiency is caused by mutations in the MAT1A gene. (Review)

9. upregulation of miR (zeige MLXIP Antikörper)-664, miR (zeige MLXIP Antikörper)-485-3p, and miR (zeige MLXIP Antikörper)-495 contributes to lower MAT1A expression in HCC (zeige FAM126A Antikörper), and enhanced tumorigenesis may provide potential targets for HCC (zeige FAM126A Antikörper) therapy.

10. Report SNPs that are highly associated with hepatic GNMT (zeige GNMT Antikörper) protein expression and the coordinate regulation of MAT1A levels.

Mouse (Murine) Methionine Adenosyltransferase I, alpha (MAT1A) Interaktionspartner

1. interplay between MATalpha1, c-Myc (zeige MYC Antikörper), and Maf (zeige MAF Antikörper) proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis

2. MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD (zeige TSC2 Antikörper) development in MAT1A-KO mice.

3. DUSP1 (zeige DUSP1 Antikörper) mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.

4. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A

5. MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor (zeige HGF Antikörper). MAT1A-produced SAMe has a major role in ERK (zeige EPHB2 Antikörper) signaling & cyclin D1 (zeige CCND1 Antikörper) regulation during liver regeneration & mitogenic signal response.

6. Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo.

7. C/EBPbeta (zeige CEBPB Antikörper) plays an important role in epigenetic regulation of the mature hepatic gene MAT1A

8. By 1 month of age, genomic instability increases in livers of Mat1a knockout mice, possibly due to reduced APEX1 (zeige APEX1 Antikörper) levels

9. CD133(+)CD45(-) oval cells isolated from premalignant 16-month-old Mat1a(-/-) mice demonstrated significant resistance to transforming growth factor-beta-induced apoptosis compared to CD133(-) cells.