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anti-Human Dihydrofolate Reductase Antikörper:
anti-Mouse (Murine) Dihydrofolate Reductase Antikörper:
anti-Rat (Rattus) Dihydrofolate Reductase Antikörper:
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Human Monoclonal Dihydrofolate Reductase Primary Antibody für IF, ELISA - ABIN560600
Ionova, Vásquez-Vivar, Whitsett, Herrnreiter, Medhora, Cooley, Pieper: Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. in American journal of physiology. Heart and circulatory physiology 2008
Show all 6 Pubmed References
Dog (Canine) Monoclonal Dihydrofolate Reductase Primary Antibody für IF, IP - ABIN968119
de Wind, Dekker, Claij, Jansen, van Klink, Radman, Riggins, van der Valk, vant Wout, te Riele: HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. in Nature genetics 1999
Show all 5 Pubmed References
Dog (Canine) Monoclonal Dihydrofolate Reductase Primary Antibody für IF, IP - ABIN968118
Eymin, Gazzeri, Brambilla, Brambilla: Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma. in Oncogene 2001
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The heat induced inactivation of DHFR follows first-order kinetics and Arrhenius law. The variation in the value of inactivation rate constant k with increasing temperatures depicts faster inactivation at elevated temperatures. Attempted to study the chaperoning ability of a shorter variant of GroEL (zeige GroEL Antikörper) (minichaperone) and compared it with that of conventional GroEL (zeige GroEL Antikörper)-GroES (zeige HSPE1 Antikörper) chaperone system.
A comparative study of various species of DHFR shows that zDHFR has comparable thermodynamic stability with human counterpart and thus proved to be a good in vitro model system for structure- function relationship studies.
Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish.
Single nucleotide polymorphism in DHFR gene is associated with Systemic lupus erythematosus.
study concludes polymorphism 63/91 in DHFR gene promoter can modulate the onset of methotrexate-related adverse effects in rheumatoid arthritis patients
our findings suggest that the identification of DHFR polymorphisms in the promoter region of the gene may be helpful in tailoring MTX (zeige MTX1 Antikörper) doses for ALL pediatric patients on maintenance therapy.
The abundance of dihydrofolate reductase was statistically significantly increased in rheumatoid arthritis (RA)-patient biopsies compared with controls and correlated with the administered dosage of methotrexate (MTX (zeige MTX1 Antikörper)), the most frequently prescribed immunosuppressive drug for RA.
The present study demonstrated that ADAR1 (zeige ADAR Antikörper) positively regulates the expression of DHFR by editing the miR (zeige MLXIP Antikörper)-25-3p and miR (zeige MLXIP Antikörper)-125a-3p binding sites in the 3'-UTR (zeige UTS2R Antikörper) of DHFR, enhancing cellular proliferation and resistance to methotrexate in MCF-7 cells.
In conclusion, the finding suggests that folate nutrition and 19bp del-DHFR [Dihydrofolate reductase] variation may interact to modify adenomatous polyp [colorectal cancer] risk.
the highest expression of GGH (zeige GGH Antikörper) and EGFR (zeige EGFR Antikörper) was noted in the left-sided colon; the highest expression of DHFR, FPGS (zeige FPGS Antikörper), TOP1 (zeige TOP1 Antikörper) and ERCC1 (zeige ERCC1 Antikörper) was noted in the rectosigmoid, whereas TYMP (zeige TYMP Antikörper) expression was approximately equivalent in the right-sided colon and rectum
Overexpression of miR (zeige MLXIP Antikörper)-192 inhibited cellular proliferation by binding DHFR. miR (zeige MLXIP Antikörper)-192 decreased cellular anchoring via the repression of ITGAV (zeige ITGAV Antikörper), ITGB1 (zeige ITGB1 Antikörper), ITGB3 (zeige ITGB3 Antikörper), and CD47 (zeige CD47 Antikörper)
Data suggest that DHFR exhibits intrinsic activity kinetics that are temperature-independent; additional mass (i.e., incorporation of H, C, and N isotopes) has no effect on intrinsic activity kinetics or protein conformation/stability of DHFR.
patients homozygous for the G allele of rs1053129 in the DHFR gene were more likely to have a metastasis (45%, P= 0.005), and the methylenetetetrahydrofolate reductase (MTHFR (zeige MTHFR Antikörper)) 677C allele was associated with higher degree of liver toxicity
The study reports arrested hematopoiesis and vascular relaxation defects in mice with a point mutation, Thr136Ala substitution in Dhfr.
S-nitrosylation of DHFR at cysteine 7 by eNOS (zeige NOS3 Antikörper)-derived NO is crucial for DHFR stability.
demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme
Robust and processive unfolding/degradation of some substrates with very stable protein domains, including mDHFR and titin (zeige TTN Antikörper)(I27) .
protects endothelial nitric oxide synthase (zeige NOS3 Antikörper) from uncoupling in tetrahydrobiopterin deficiency
Dhfr has a role in folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation (zeige HELLS Antikörper)
E2F (zeige E2F1 Antikörper)-responsive dihydrofolate reductase promoter regulates the balance between acetylation and methylation of histone H3 (zeige HIST3H3 Antikörper) lysine 9
translocation of the DHFR domain was greatly impaired when it was separated from the signal-anchor sequence
mechanical stability of mouse dihydrofolate reductase is dominated by local interactions within the protein structure
Crystal structures are reported for NADPH (zeige FDXR Antikörper) ternary complexes with PY1011 and mouse DHFR (mDHFR), refined to 2.2 A resolution.
Hydrogen peroxide down regulates expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase (zeige NOS3 Antikörper) dysfunction.
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
, dihydrofolate reductase DhfR
, Dihydrofolate reductase
, Dihydrofolate reductase 1 (active)