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anti-Human DBF4 Antikörper:
anti-Rat (Rattus) DBF4 Antikörper:
anti-Mouse (Murine) DBF4 Antikörper:
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Human Monoclonal DBF4 Primary Antibody für IF, ELISA - ABIN564742
Hughes, Jenkins, Dar, Engelman, Cherepanov: Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity. in The Journal of biological chemistry 2009
Mouse (Murine) Polyclonal DBF4 Primary Antibody für ELISA, WB - ABIN4304355
Tsuji, Lau, Chiang, Jiang: The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. in Molecular cell 2008
Histone H3 (zeige HIST3H3 Antikörper) lysine 9 (H3K9) acetylation was most prevalent when the Dbf4 transcription level was highest whereas the H3K9me3 level was greatest during and just after replication.
we propose that phosphorylation of TOP2A (zeige TOP2A Antikörper) by CDC7 (zeige CDC7 Antikörper)/DBF4 in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A (zeige TOP2A Antikörper) function could be relevant to prevent premature separation of centromeric DNA.
The anti-invasive and cell cycle arrest-inducing effects of nitrogen-containing bisphosphonates are not DBF4 mediated in human breast cancer cells.
Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
bipartite interaction between Cdc7 (zeige CDC7 Antikörper) and Dbf4/ASK subunits facilitates ATP binding and substrate recognition by the Cdc7 (zeige CDC7 Antikörper) kinase.
Dbf4 regulates the Cdc5 (zeige CDC5L Antikörper) Polo-like kinase (zeige PLK1 Antikörper) through a distinct non-canonical binding interaction
Data document the role of DBF4 as a key player in nitrogen-containing bisphosphonate-induced cytotoxicity, thus explaining the effects on the cell-cycle.
The interaction with LEDGF (zeige PSIP1 Antikörper) relieves autoinhibition of Cdc7 (zeige CDC7 Antikörper)-ASK kinase, imposed by the C terminus of ASK.
results suggest that E2F (zeige E2F1 Antikörper) regulates the ASK promoter through an atypical mode of recognition of the target site
The HuDbf4 gene has of 12 exons over a 33-kb region. The MluI cell-cycle box is needed for core promoter activation. The Sp1 upregulator & HES-1 repressor coordinately determine promoter efficiency. Transcription initiations occur at -220, -235 and -245.
Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Not required during the initiation of DNA replication in egg and during early embryonic development but is required later and throughout development. The complex cdc7-dbf4a phosphorylates mcm2 subunit.
DBF4-type zinc finger-containing protein 1
, activator of S phase kinase
, chiffon homolog A
, protein DBF4 homolog A
, zinc finger, DBF-type containing 1
, DBF4 homolog (S. cerevisiae)
, protein DBF4 homolog A-like
, DBF4 homolog