TUBA1A Proteine (Tuba1a)

Bezeichnung:: Tubulin, alpha 1a Proteine (Tuba1a)

Auf www.antikoerper-online.de finden Sie aktuell 13 Tubulin, alpha 1a (Tuba1a) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TUBA1A Antikörper (42) und TUBA1A Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 64 TUBA1A Produkte verfügbar.

Synonyme:: alphatub84, b-alpha-1, lis3, Tuba-1, Tuba1, tuba1a, tuba1a-a, tuba1a-b, Tuba2, tuba3, TUBA3D, TUBA3E, wu:fb37a10

alle Proteine anzeigen	Gen	GeneID	UniProt
Ratte Tuba1a	Tuba1a	64158	P68370
	Tuba1a	7846	Q71U36
	Tuba1a	22142	P68369
Weitere Synonyme anzeigen

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Human Tubulin, alpha 1a (Tuba1a) Interaktionspartner

A de novo heterozygous c.320A>G [p.(His 107 Arg)] mutation in TUBA1A was identified in a patient with microcephaly, epileptic seizures, and severe developmental delay.
Given that Spastin engages the MT in two places, we propose that severing occurs by forces exerted on the C-terminal tail of tubulin, which results in a conformational change in tubulin, which releases it from the polymer.
Molecular docking studies revealed that 6f interacted and bound ef fi ciently with the colchicine-binding site of tubulin. In addition, 6f treatment induced G2/M cell cycle arrest dose-dependently and subsequently induced cell apoptosis
induced pluripotent stem cells (iPSCs) from the umbilical cord and peripheral blood of two lissencephaly patients with different clinical severities carrying alpha tubulin (TUBA1A) missense mutations, were generated.
Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing alpha-tubulin acetylation in breast cancer.
Results show that Tuba1a plays an essential, noncompensated role in neuronal saltatory migration in vivo and highlight the importance of microtubule flexibility in nucleus-centrosome coupling and neuronal-branching regulation during neuronal migration.
data suggest that the TUBA1A mutations disrupting lateral interactions have pronounced dominant-negative effects on microtubule dynamics that are associated with the severe end of the lissencephaly spectrum
Data show that tubulin phosphorylation and acetylation play important roles in the control of microtubule assembly and stability.
Data show that plasma membrane Ca(2+)-ATPase (PMCA) was associated with tubulin in normotensive and hypertensive erythrocytes.
Data suggest that tubulin functionally interact with the vimentin network in a cell-type specific manner.
Studies indicate that alpha-tubulin acetylation and microtubule level is mainly governed by opposing actions of alpha-tubulin acetyltransferase 1 (ATAT1) and histone deacetylase 6 (HDAC6).
Data from studies using peptide fragment of alpha-tubulin (residues 31-49) suggest that Ser38 is crucial for substrate recognition by alpha-tubulin acetylase 1 (ATAT1); Asp39, Ile42, the glycine stretch (residues 43-45), and Asp46 are also involved.
Lysine 40 acetylation of alpha-tubulin does not result in significant changes in kinesin-1's landing rate or motility parameters.
These results demonstrated that SelP interacts with tubulin, alpha 1a (TUBA1A).
This study show all foetuses with lissencephaly and cerebellar hypoplasia carried distinct TUBA1A mutations.
These findings call attention to PKC-mediated phosphorylation of alpha-tubulin as a novel mechanism for controlling the dynamics of microtubules that result in cell movement.
case provides new insight into the wide spectrum of disease phenotypes associated with TUBA1A mutation
The present study confirms that mutations in tubulin genes are responsible for complex brain malformation.
Studies suggest that tubulin-interactive agents have the potential to play a significant role in the fight against cancer.
Missense mutations in TUBA1A were found in 3 patients with polymicrogyria.

Cow (Bovine) Tubulin, alpha 1a (Tuba1a) Interaktionspartner

Lys40 of alpha-tubulin acetylation directly weakens inter-protofilament interactions.
the role of the human TBCE and TBCB chaperones in alpha-tubulin-beta-tubulin dissociation, was investigated.
Lysine 40 acetylation of alpha-tubulin does not result in significant changes in kinesin-1's landing rate or motility parameters.
Data suggest presence of unstructured C-terminal tubulin tail in Vdac1 pore (voltage-dependent anion channel 1) decreases pore's conductance and switches pore's selectivity from anionic to cationic rendering ATP transport virtually impossible.
TTL has specifically evolved to recognize and modify tubulin.
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin.

TUBA1A (Tuba1a) Protein Überblick

Protein Überblick

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with TUBA1A (Tuba1a)

tubulin, alpha 1A (Tuba1a)
tubulin alpha 1a (TUBA1A)
tubulin, alpha 1a (TUBA1A)
tubulin alpha-1B chain (LOC608147)
tubulin alpha-1A chain (LOC100392817)
tubulin alpha-3 chain-like (LOC425049)
tubulin, alpha 1a (tuba1a)
tubulin alpha-1A chain (LOC100051840)
tubulin alpha-1A chain (LOC100340483)
tubulin alpha-1A chain (LOC100726777)
tubulin alpha 1a L homeolog (tuba1a.L)

alphatub84 Protein
b-alpha-1 Protein
lis3 Protein
Tuba-1 Protein
Tuba1 Protein
tuba1a Protein
tuba1a-a Protein
tuba1a-b Protein
Tuba2 Protein
tuba3 Protein
TUBA3D Protein
TUBA3E Protein
wu:fb37a10 Protein

Bezeichner auf Proteinebene für Tubulin, alpha 1a Proteine (Tuba1a)

, , , , , , , , , , , , , , , , , , , , , , , , , , , , alpha-tubulin 1 tubulin alpha-1 chain tubulin alpha-1A chain tubulin, alpha 1 hum-a-tub1 hum-a-tub2 tubulin B-alpha-1 tubulin alpha-3 chain tubulin, alpha, brain-specific alpha-tubulin 3 tubulin, alpha 3 Talpha1 alpha-tubulin alpha-tubulin isotype M-alpha-1 alpha-tubulin ubiquitous tubulin K-alpha-1 tubulin alpha-1B chain tubulin alpha-ubiquitous chain tubulin, alpha 1a tubulin alpha-1A chain-like tubulin, alpha 3d tubulin, alpha 3e Alpha-tubulin 1 Tubulin alpha-1 chain tubulin alpha 3 Alpha-tubulin 2 Alpha-tubulin II Tubulin alpha-2 chain alpha-tubulin II tubulin alpha 1a L homeolog

GENE ID	SPEZIES
64158	Rattus norvegicus
7846	Homo sapiens
451875	Pan troglodytes
22142	Mus musculus
404053	Bos taurus
608147	Canis lupus familiaris
100392817	Callithrix jacchus
100445613	Pongo abelii
425049	Gallus gallus
573216	Danio rerio
100135051	Sus scrofa
100051840	Equus caballus
100340483	Oryctolagus cuniculus
100726777	Cavia porcellus
100682527	Cricetulus griseus
431994	Xenopus laevis
101865772	Macaca fascicularis

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