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The novel protein SOGA1 was confirmed to colocalize with a microtubule-associated protein CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein.
data reveal that CLASP2 is an essential Reelin effector orchestrating cytoskeleton dynamics during brain development.
These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features.
A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.
the functional relationship between Abl and CLASP2 is conserved and provides a means to control the CLASP2 association with the cytoskeleton.
The MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120) in primary basal mouse keratinocytes.
CLASP2 is required for the proper attachment of fibroblasts, HSC-enriched cells, and platelets, indicating a general role for this protein in cell attachment.
CLASP2 directs the delivery of GLUT4 to cell cortex landing zones important for insulin action
Short-hairpin RNA-mediated CLASP2 knockdown in mouse neurons decreases axon & dendritic length. It is involved in cytoskeleton-related neuronal polarity & interplay between microtubule stabilization & synapse formation & activity.
the cascade linking agrin to CLASP2-mediated microtubule capturing at the synaptic membrane is essential for the maintenance of a normal neuromuscular phenotype
Together, our data support that the partial redundancy of CLASPs during mitosis acts as a possible mechanism to prevent aneuploidy in mammals.
Regional immobilization of CLASP2 allows MT stabilization and promotes directionally persistent motility in fibroblasts.
CLASP2 is involved in the epithelial-mesenchymal transition and progression of bladder urothelial cancer. Simultaneous urine-based detection of CLASP2 and E-cadherin mRNA can efficiently discriminate patients with or without 2-years progression after transurethral resection of the bladder tumor.
Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions.
this study shows that GSK3-mediated phosphorylation of CLASP2alpha largely abolishes CLASP2alpha-microtubule association in metaphase thus contributing to correct chromosome dynamics
PAR3 and aPKC control the organization of the Golgi through CLASP2 phosphorylation.
GSK3B-dependent phosphorylation and the level of CLASP2 play a role in the maintenance of acetylcholine receptor cluster size through the regulated capture and release of microtubule plus-ends.
Propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM, establishing a local secretion pathway that facilitates focal adhesion turnover by severing cell-matrix connections.
Interstitial deletion of 3p22.3p22.2 encompassing ARPP21 and CLASP2 is a potential pathogenic factor for a syndromic form of intellectual disability.
Results suggest a previously unidentified role for the scaffolding protein 4.1R in locally controlling CLASP2 behavior, CLASP2 cortical platform turnover and GSK3 activity, enabling correct MT organization and dynamics essential for cell polarity.
The epiblast epithelial status was maintained by anchoring microtubules to the basal cortex via CLIP2, a microtubule plus-end tracking protein, and Dystroglycan, a transmembrane protein that bridges the cytoskeleton and basement membrane (BM).
Overexpression of human CLASP2 in mouse neurons caused the formation of multiple axons, enhanced dendritic branching, & Golgi condensation. These morphogenetic changes led to significant functional alterations in synaptic transmission.
propose that Cdk1 and Plk1 mediate a fine CLASP2 "phospho-switch" that temporally regulates kinetochore-microtubule attachment stability
Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).
Data show that CENP-E-mediated traction forces on misaligned chromosomes are responsible for the irreversible loss of spindle-pole integrity in CLASP1/2-depleted cells.
Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP
Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro.
propose that CLASP1 and CLASP2 can mediate interactions between microtubule plus ends and the cell cortex and act as local rescue factors, possibly through forming a complex with EB1 at microtubule tips
These results demonstrate the striking difference of the microtubule cytoskeleton in the lamella as compared with the cell body and provide the first direct observation of subcellular regulation of a microtubule-associated protein in migrating cells.
CLASPs provide apparent stabilization of microtubules by locally reducing the amplitude of growth/shortening episodes at the microtubule ends.
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (By similarity).
CLIP-associating protein 2
, cytoplasmic linker-associated protein 2
, cytoplasmic linker associated protein 2
, CLIP-associating protein CLASP2
, multiple asters (Mast)-like homolog 2
, protein Orbit homolog 2
, CLIP associating protein 2