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data reveal that CLASP2 is an essential Reelin (zeige RELN Proteine) effector orchestrating cytoskeleton dynamics during brain development.
These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features.
A transport system, organized by agrin (zeige AGRN Proteine) through PI3 kinase (zeige PIK3CA Proteine), GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor (zeige CHRNB1 Proteine) vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.
the functional relationship between Abl (zeige ABL1 Proteine) and CLASP2 is conserved and provides a means to control the CLASP2 association with the cytoskeleton.
The MT plus end-binding protein CLASP2 localizes to adherens junctions (AJs) via direct interaction with p120-catenin (p120 (zeige CTNND1 Proteine)) in primary basal mouse keratinocytes.
CLASP2 is required for the proper attachment of fibroblasts, HSC (zeige FUT1 Proteine)-enriched cells, and platelets, indicating a general role for this protein in cell attachment.
CLASP2 directs the delivery of GLUT4 (zeige SLC2A4 Proteine) to cell cortex landing zones important for insulin (zeige INS Proteine) action
Short-hairpin RNA-mediated CLASP2 knockdown in mouse neurons decreases axon & dendritic length. It is involved in cytoskeleton-related neuronal polarity & interplay between microtubule stabilization & synapse formation & activity.
the cascade linking agrin (zeige AGRN Proteine) to CLASP2-mediated microtubule capturing at the synaptic membrane is essential for the maintenance of a normal neuromuscular phenotype
Regional immobilization of CLASP2 allows MT stabilization and promotes directionally persistent motility in fibroblasts.
CLASP2 is involved in the epithelial-mesenchymal transition and progression of bladder urothelial cancer. Simultaneous urine-based detection of CLASP2 and E-cadherin (zeige CDH1 Proteine) mRNA can efficiently discriminate patients with or without 2-years progression after transurethral resection of the bladder tumor.
Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions.
this study shows that GSK3-mediated phosphorylation of CLASP2alpha largely abolishes CLASP2alpha-microtubule association in metaphase thus contributing to correct chromosome dynamics
PAR3 (zeige F2RL2 Proteine) and aPKC control the organization of the Golgi through CLASP2 phosphorylation.
GSK3B-dependent phosphorylation and the level of CLASP2 play a role in the maintenance of acetylcholine receptor (zeige CHRNA1 Proteine) cluster size through the regulated capture and release of microtubule plus-ends.
Propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM (zeige MMRN1 Proteine), establishing a local secretion pathway that facilitates focal adhesion turnover by severing cell-matrix connections.
Interstitial deletion of 3p22.3p22.2 encompassing ARPP21 (zeige ARPP21 Proteine) and CLASP2 is a potential pathogenic factor for a syndromic form of intellectual disability.
Results suggest a previously unidentified role for the scaffolding protein 4.1R in locally controlling CLASP2 behavior, CLASP2 cortical platform turnover and GSK3 activity, enabling correct MT organization and dynamics essential for cell polarity.
The epiblast epithelial status was maintained by anchoring microtubules to the basal cortex via CLIP2, a microtubule plus-end tracking protein, and Dystroglycan, a transmembrane protein that bridges the cytoskeleton and basement membrane (BM).
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (By similarity).
CLIP-associating protein 2
, cytoplasmic linker-associated protein 2
, cytoplasmic linker associated protein 2
, CLIP-associating protein CLASP2
, multiple asters (Mast)-like homolog 2
, protein Orbit homolog 2
, CLIP associating protein 2