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Genotypes of transcobalamin 2 (TCN2 (zeige TCN2 Proteine)) rs1801198, methionine synthase (MTR) rs1805087, methionine synthase reductase (MTRR (zeige MTRR Proteine)) rs1801394, and methylene tetrahydrofolate reductase (MTHFR (zeige MTHFR Proteine)) rs1801133 were examined in 201 children with Autism Spectrum Disorder and 200 healthy controls from the Han Chinese population. Our results showed no association of all examined SNPs with childhood ASD (zeige ARSD Proteine) and its severity.
Methylene tetrahydrofolate reductase (MTHFR (zeige MTHFR Proteine)) C677T, 5-methyltetrahydrofolate homocysteine methyltransferase (MTR) A2756G and 5- methyltetrahydrofolate homocysteine methyltransferase reductase (MTRR (zeige MTRR Proteine)) A66G were shown to be positively associatiated with homocysteine, while nonvegetarian diet, serine hydroxymethyltransferase 1 (SHMT1 (zeige SHMT1 Proteine)) C1420T and TYMS (zeige TYMS Proteine) 5'-UTR 28 bp tandem repeat exhibited negative association with homocysteine.
GG homozygous and G alleles of methionine synthase A2756G polymorphism were not associated with risks of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), the subtype of NHL including the diffuse large B-cell lymphoma and follicular lymphoma.
SNPs in folate pathway genes MTHFR (zeige MTHFR Proteine)/ MTR/ACE (zeige ACE Proteine) and hyperhomocysteinemia have roles in risk of coronary artery disease.
Data indicate that two noncoding 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) variants, rs28372871 and rs1131450 were independently associated with a significantly increased risk of prostate cancer (PCa (zeige FLVCR1 Proteine)).
Based on the results, an MTRA2756G polymorphism which changes activity and stability of the methionine synthase associated with prostate cancer in men.
MTR CpG sites were hypermethylated in preterm placenta. Methylated CpG sites were negatively associated with maternal plasma vitamin B12 (zeige NDUFB3 Proteine) levels.
tagSNPs in MTHFR (zeige MTHFR Proteine), MTR, MTRR (zeige MTRR Proteine), and TCN2 (zeige TCN2 Proteine) were not associated with NSCLP in our study, but continued exploration, including allele frequency of various populations and molecular mechanism of the gene-gene interactions of the genes, may provide additional insight into NSCLP.
MTHFR (zeige MTHFR Proteine) A1298C and MS A2756G polymorphisms may be unrelated to male infertility.
The evaluation of genetic association showed that, MTHFR (zeige MTHFR Proteine) C6877T (OR: 8.89, 95% CI: 2.01-39.40) and MTR A2756G (OR: 1.48, 95% CI: 1.09-2.00) polymorphisms associated with higher risk of CVD.
These findings indicate that greater synthesis of phosphatidylcholine (zeige SGMS1 Proteine) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G.
5-methyltetrahydrofolate-homocysteine methyltransferase 1
, cobalamin-dependent methionine synthase
, methionine synthase
, vitamin-B12 dependent methionine synthase
, 5-methyltetrahydrofolate--homocysteine methyltransferase