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The MTR A2756G polymorphism may influence the development risk of pediatric acute lymphoblastic leukemia in Caucasians. (Meta-analysis)
The change of the Hcy level was not proportional to the severity of the disease in different groups of OSAHS patients, and CPAP [continuous positive airway pressure ]did not affect the Hcy [homocysteine]levels.
MTR polymorphisms may contribute to the risk of gastric cancer in Chinese Han population.
combined genotypes of MTHFR 677 CT with MTR 2756 AA and MTHFR 677 CT with MTRR AG added to the potential risk in Chinese Down syndrome mothers
Utilizing whole-exome sequencing, we found two novel MTR variants c.871C>T (p.Pro291Ser) and c.1771C>T (p.Arg591*) in Patient 1, and a ABCD4 homozygous variant c.423C>G (p.Asn141Lys) in Patient 2. Our study identified the first Cobalamin Gpatient and cobalamin J patient in mainland China, and highlighted comprehensive metabolic analyses and genetic tests in patients suspected of cobalamin defects
These data show that the processing of cobalamin in cytoplasm occurs in a multiprotein complex composed of at least methionine synthase, methionine synthase reductase, MMACHC and MMADHC.
study indicated that SNPs of MTR have relatively limited or no roles in the genesis of cachexia in patients with gastrointestinal cancers
12 articles were included in this study. The pooled results did not reveal a significant association of the MTR A2756G polymorphism with Nonsyndromic Cleft Lip With or Without Cleft Palate risk (G vs. A: OR = 0.95, 95% CI = 0.82-1.11, p = 0.55).
Genotypes of transcobalamin 2 (TCN2) rs1801198, methionine synthase (MTR) rs1805087, methionine synthase reductase (MTRR) rs1801394, and methylene tetrahydrofolate reductase (MTHFR) rs1801133 were examined in 201 children with Autism Spectrum Disorder and 200 healthy controls from the Han Chinese population. Our results showed no association of all examined SNPs with childhood ASD and its severity.
Methylene tetrahydrofolate reductase (MTHFR) C677T, 5-methyltetrahydrofolate homocysteine methyltransferase (MTR) A2756G and 5- methyltetrahydrofolate homocysteine methyltransferase reductase (MTRR) A66G were shown to be positively associatiated with homocysteine, while nonvegetarian diet, serine hydroxymethyltransferase 1 (SHMT1) C1420T and TYMS 5'-UTR 28 bp tandem repeat exhibited negative association with homocysteine.
GG homozygous and G alleles of methionine synthase A2756G polymorphism were not associated with risks of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), the subtype of NHL including the diffuse large B-cell lymphoma and follicular lymphoma.
SNPs in folate pathway genes MTHFR/ MTR/ACE and hyperhomocysteinemia have roles in risk of coronary artery disease.
Data indicate that two noncoding 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) variants, rs28372871 and rs1131450 were independently associated with a significantly increased risk of prostate cancer (PCa).
no difference in genotype frequencies between pre-eclampsia patients and controls
Based on the results, an MTRA2756G polymorphism which changes activity and stability of the methionine synthase associated with prostate cancer in men.
MTR CpG sites were hypermethylated in preterm placenta. Methylated CpG sites were negatively associated with maternal plasma vitamin B12 levels.
tagSNPs in MTHFR, MTR, MTRR, and TCN2 were not associated with NSCLP in our study, but continued exploration, including allele frequency of various populations and molecular mechanism of the gene-gene interactions of the genes, may provide additional insight into NSCLP.
MS A2756G polymorphism may not be a risk factor for hematological cancer.
MTHFR A1298C and MS A2756G polymorphisms may be unrelated to male infertility.
The evaluation of genetic association showed that, MTHFR C6877T (OR: 8.89, 95% CI: 2.01-39.40) and MTR A2756G (OR: 1.48, 95% CI: 1.09-2.00) polymorphisms associated with higher risk of CVD.
Deficiency of either MS or folate produces oxidative stress and endothelial dysfunction in the cerebral microcirculation of mice.
These findings indicate that greater synthesis of phosphatidylcholine and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G.
5-methyltetrahydrofolate-homocysteine methyltransferase 1
, cobalamin-dependent methionine synthase
, methionine synthase
, vitamin-B12 dependent methionine synthase
, 5-methyltetrahydrofolate--homocysteine methyltransferase