anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antikörper

Bezeichnung:: anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antikörper (SRD5A2)

Auf www.antikoerper-online.de finden Sie aktuell 70 Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antikörper von 12 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Kits (27) und Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 110 Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Produkte verfügbar.

Synonyme:: 5ART2, S5AR 2, Srd5a2, SRD5alpha2

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	SRD5A2	94224	Q99N99
	SRD5A2	6716	P31213
	SRD5A2	64677	P31214
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Am meisten referenzierte anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Antikörper

Human Monoclonal SRD5A2 Primary Antibody für ELISA, WB - ABIN520465 : Sato, Iemitsu, Matsutani, Kurihara, Hamaoka, Fujita: Resistance training restores muscle sex steroid hormone steroidogenesis in older men. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 (PubMed)
Human Polyclonal SRD5A2 Primary Antibody für ELISA, WB - ABIN451821 : Torkko, van Bokhoven, Mai, Beuten, Balic, Byers, Hokanson, Norris, Barón, Lucia, Thompson, Leach: VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White men. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008 (PubMed)
Human Polyclonal SRD5A2 Primary Antibody für ELISA - ABIN268809 : Iczkowski, Qiu, Qian, Somerville, Rittmaster, Andriole, Bostwick: The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. in Urology 2005 (PubMed)
Human Polyclonal SRD5A2 Primary Antibody für ELISA, WB - ABIN562991 : Park, Aizawa, Iemitsu, Sato, Akimoto, Agata, Maeda, Ezawa, Omi: DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats. in Calcified tissue international 2011 (PubMed)
Human Polyclonal SRD5A2 Primary Antibody für IHC, WB - ABIN2781788 : Bertin, Dury, Ouellet, Pelletier, Labrie: Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction. in The journal of sexual medicine 2014 (PubMed)

Weitere Antikörper gegen Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) Interaktionspartner

Mouse (Murine) Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Interaktionspartner

Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor (zeige AR Antikörper) and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (zeige DPT Antikörper) mice
observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes
The induction of Srd5a2 through SREBP-2 (zeige SREBF2 Antikörper) provides a mechanistic explanation for why even though statin therapy is effective in reducing cholesterol levels in treating hypercholesterolemia it does not compromise androgen production in clinical studies.

Human Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Interaktionspartner

mutations of the SRD5A2 gene are the main causes of posterior hypospadias
Findings suggest that 5alpha-reductases (5-AR) isoenzymes could be explored as a therapeutic target for urothelial bladder cancer (UBC (zeige RPS27A Antikörper)) with 5alpha-reductase inhibitors (5-ARI (zeige ARIH1 Antikörper)).
Lack of SRD5A2 expression in the prostate induces an androgenic to oestrogenic switch in human benign prostatic tissues.
deficiency of 5-alpha reductase type 2 was considered and SRD5A2 was sequenced. This identified homozygous pathogenic variants in SRD5A2 (p. Pro212Arg), which confirmed a diagnosis of deficiency of 5-alpha reductase type 2
Chromosomal anomalies and mutations of the SRD5A2 gene are associated with hypospadias.
Polymorphism in the SRD5A2 gene is associated with hypospadias.
In a recent study we reported associations between ALTs and single nucleotide polymorphisms (SNPs) in the genes encoding estrogen receptor 1 (ESR1 (zeige ESR1 Antikörper)), steroid-5-alpha-reductase, type 2 (SRD5A2) and sex hormone-binding globulin (SHBG (zeige SHBG Antikörper)). No associations between the previously associated SNPs in the genes ESR1 (zeige ESR1 Antikörper) and SRD5A2 and autistic-like traits could be seen in the large replication sample.
Studies indicate that enhanced 5alpha-reductase activity in subjects with polycystic ovary syndrome (PCOS) was associated with insulin (zeige INS Antikörper) resistance (IR) rather than obesity.
Mutations in the SRD5A2 cause a disorder of 46,XY sex development, termed 5alpha-reductase type 2 deficiency. (Review)
Meta-analysis of 20 publications incorporating 30 case-control studies indicated that the SRD5A2 rs9282858 polymorphism may be a susceptible factor to prostate cancer.

Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antigen-Profil

Beschreibung des Gens

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).

Alternative names and synonyms associated with Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2)

steroid 5 alpha-reductase 2 (SRD5A2) Antikörper
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (srd5a2) Antikörper
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (LOC100125532) Antikörper
steroid 5 alpha-reductase 2 (Srd5a2) Antikörper

5ART2 Antikörper
S5AR 2 Antikörper
Srd5a2 Antikörper
SRD5alpha2 Antikörper

Bezeichner auf Proteinebene für SRD5A2

3-oxo-5-alpha-steroid 4-dehydrogenase 2 , steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) , steroid-5-alpha-reductase alpha polypeptide 2 , 5 alpha-SR2 , SR type 2 , steroid 5 alpha reductase type2 , steroid 5-alpha-reductase 2 , S5AR 2 , type II 5-alpha reductase , prostatic steroid 5-alpha-reductase type II

GENE ID	SPEZIES
527024	Bos taurus
772291	Gallus gallus
549867	Xenopus (Silurana) tropicalis
705676	Macaca mulatta
100125532	Oryzias latipes
94224	Mus musculus
397048	Sus scrofa
6716	Homo sapiens
64677	Rattus norvegicus
403715	Canis lupus familiaris

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Show all anti-Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Antikörper with Pubmed References

Mouse (Murine) Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Interaktionspartner

Human Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2) Interaktionspartner

Beschreibung des Gens

Alternative names and synonyms associated with Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2)

Bezeichner auf Proteinebene für SRD5A2