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Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.
These studies implicate altered Lrp2-mediated homeostasis as important for myopia and other risk factors for glaucoma.
Megalin mediates transepithelial albumin clearance from the alveolar space of intact rabbit lungs
low-level LPS-mediated TNF-alpha-ERK1/2 signaling pathway is involved in downregulation of megalin expression in IRPTCs.
megalin is associated with progression factors of diabetic nephropathy as well as vitamin D deficiency
The LRP2 rs12988804*T allele is associated with a 1.16-fold increased hazard rate for a relapse occurring
To examine the direct effects of the miRNAs on megalin and other membrane proteins expression, proximal tubule LLC-PK1 cells were transfected with miR-148b, miR-21, miR-146a, or miR-192 mimics. Transfection with miR-148b mimic, but not the other three miRNA mimics inhibited endogenous megalin mRNA expression.
Expression of the extracellular receptor of vitamin D binding protein, LRP2, was positively associated with West African ancestry and inversely associated with prostate 25(OH)D concentrations in African Americans.
Mild oxidative stress increases renal megalin expression through the phosphatidylinositol 3-kinase-Akt pathway in the normoalbuminuric stage of diabetes mellitus.
Mutation in the LRP2 gene is associated with Donnai-Barrow syndrome.
Analysis of serum folate and active-B12 levels revealed significant association with LRP2 gene variants in the causation of neural tube defects.
megalin is critical for mitochondrial biology; mitochondrial intracrine signaling is a continuum of the retrograde early endosome-to-Golgi-Rab32 pathway and defects in this pathway may underlie disease processes in many systems.
patients with OCRL-1 mutations or type 1 Dent disease showed abnormally low levels of urinary A-megalin
An Emerging Role for Megalin as a Regulator of Protein Leak in Acute Lung Injury.
Review of LRP2 function. LRP2 functions are crucial for developmental processes in a number of tissues, including the brain, the eye, and the heart, and defects in this receptor pathway are the cause of devastating congenital diseases in humans.
A novel LRP2 missense variant rs17848169 (N2632D) was found to be associated with lower risk for T2D-ESRD in this population.
we discovered one novel locus (LRP2; most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).
miR-148b directly down-regulates renal megalin expression.
Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules.
The studies suggest that impaired endocytosis of megalin/cubilin ligands, hemoglobin and albumin, rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.
VDR and MEGALIN gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.
the main role for placental megalin is not to mediate uptake of nutrients from the maternal bloodstream; results point toward novel and complex functions for megalin in the cytotrophoblasts.
specific miRNA-146a regulation may contribute to Alzheimer's disease by downregulating the Lrp2/Akt pathway
abundances of megalin and Dab2 (p = 0.046) were reduced in infected placentas from women with LBW deliveries
Low megalin expression is associated with proteinuria.
Cuprizone-induced demyelination is followed by high upregulation of MT-I/II and megalin immunoreactivity in astrocytes and epithelial and endothelial cells located in cerebral and cerebellar white and gray matter, as well as in choroid plexus and in numerous constituents of the neurogenic niches in subgranular zone (SGZ) of DG and in SVZ of lateral ventricles.
TTR neuritogenic activity is mediated by the megalin receptor and is lost in megalin-deficient neurons.
in a bleomycin-based model of acute lung injury, megalin(+/-) animals (the megalin(-/-) variant is lethal due to postnatal respiratory failure) showed a marked increase in intra-alveolar protein and more severe lung injury compared with wild-type littermates
Cell type-specific glycoforms of megalin exist in the proximal tubular cells and modulate ligand absorption capacity.
This study evaluated the role of transcobalamin (TC), the transcobalamin receptor (CD320) , and megalin in various tissues during pregnancy.
miR-148b negatively regulates megalin expression in unilateral ureteral obstruction-induced kidney injury.
study reveals a cross talk between ATR signaling and DPP4 activation in the regulation of megalin and underscores the significance of targeting DPP4 in the prevention of obesity related kidney injury progression.
LRP2 plays a crucial role in cardiovascular development in mice.
Foxg1-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia
megalin-deficient mice may provide a valuable model for future studies of megalin in ocular physiology and pathology.
LRP2 is essential for cellular folate uptake in the developing neural tube, a crucial step for proper neural tube closure.
we have identified hypothalamic clusterin as a novel anorexigenic molecule that can potentiate central leptin activity.
Multiligand endocytic receptor megalin may be involved in AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells.
SNPs in the CYP24A1, CYP2R1, calcium sensing receptor (CASR), vitamin D binding protein (GC), retinoid X receptor-alpha (RXRA) and megalin (LRP2) genes were significantly associated with pancreas cancer risk.
Lrp2 is a novel target gene by progesterone and progesterone receptor.
The hypothalamic clusterin-low-density lipoprotein receptor-related protein-2 axis is a novel anorexigenic signalling pathway.
Data indicate that uptake of Sepp1 and Gpx3 by d-13 visceral yolk sac was independent of apoER2 and megalin.
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
low density lipoprotein-related protein 2
, low-density lipoprotein receptor-related protein 2
, low density lipoprotein receptor-related protein 2
, low-density lipoprotein receptor-related protein 2-like
, Heymann nephritis antigen homolog
, calcium sensor protein
, glycoprotein 330