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Human AKR1B1 Protein expressed in Wheat germ - ABIN1344744
Atsriku, Hoffmann, Moghaddam, Kumar, Surapaneni: In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism. in Xenobiotica; the fate of foreign compounds in biological systems 2015
AKR1B1 rs759853 polymorphism had no association with diabetic retinopathy (DR) risk under all genetic models. However, after subgroup analysis by diabetes mellitus; type, the rs759853 polymorphism was a protective factor against the DR onset in patients with type 1 diabetes mellitus; Subgroup analysis by genotyping method suggested that rs759853 was significantly correlated with decreased risk of DR under dominate model
A combined gene expression signature of AKR1B10 (zeige AKR1B10 Proteine) (low) and AKR1B1 (high) showed a better prognostic stratification of CRC (zeige CALR Proteine) patients independent of confounding factors.
Data show that cells with higher levels of aldo-keto reductases AKR1B1 and/or AKR1B10 (zeige AKR1B10 Proteine) (AKR1Bs) were more sensitive to 2-deoxyglucose (2DG).
genetic association studies in population in north India: Data suggest that an SNP in promoter region of aldose reductase (C-106T) is associated with peripheral neuropathy in patients with type 2 diabetes mellitus in the population studied.
Under hyperglycemic conditions, aldose reductase (AR)-mediated sorbitol formation and associated rise in cell volume, which subsequently results in platelet hyperactivation, occur.
An meta-analysis showed that aldose reductase C-106T variants appear to influence the risk for diabetic retinopathy in Chinese Han persons (meta-analysis).
AKR1B1 as a key modulator of tumor aggressiveness and suggests that pharmacologic inhibition of AKR1B1 has the potential to become a valuable therapeutic strategy for Basal-like breast cancer (BLBC).
Result indicate that the differential scanning fluorimetry (DSF) method is useful for enzyme inhibitor drug screening for the AKR superfamily, including AKR1B10 (zeige AKR1B10 Proteine) and a structurally similar isoform AKR1B1.
The hyperosmotic AR gene expression was dependent on activation of metalloproteinases, autocrine/paracrine TGF-beta (zeige TGFB1 Proteine) signaling, activation of p38 MAPK (zeige MAPK14 Proteine), ERK1/2, and PI3K (zeige PIK3CA Proteine) signal transduction pathways, and the transcriptional activity of NFAT5 (zeige NFAT5 Proteine).
Aberrant DNA methylation (zeige HELLS Proteine) of AKR1B1 could be potential screening markers of colorectal cancer.
Aldose reductase acts as a switch which can regulate microglia by polarizing cells after spinal cord injury.
Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53 (zeige TP53 Proteine).
Data indicate that inhibition of AR alleviates the MCD (zeige MLYCD Proteine) diet-induced liver inflammation and fibrosis in db/db (zeige LEPR Proteine) mice, probably through dampening CYP2E1 (zeige CYP2E1 Proteine) mediated-oxidative stress and ameliorating the expression of pro-inflammatory cytokines.
FMHM suppressed the activity of AR-dependent phospholipase C (zeige PLC Proteine)/protein kinase C signaling, which further resulted in downstream inactivation of the IkappaB kinase (zeige CHUK Proteine)/IkappaB/nuclear factor-kappa B inflammatory pathway.
Allergen-induced airway remodeling is mediated by AR and its inhibition blocks the progression of remodeling via inhibiting TGFbeta1-induced Smad-independent and PI3K/AKT/GSK3beta-dependent pathway.
BGG-mediated inhibition of aldose reductase prevented LPS (zeige TLR4 Proteine)-induced activation of JNK (zeige MAPK8 Proteine).
crystal of AKR1B3 was tetragonal, belonging to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 107.62, c = 120.76 A
the role of AKR1B3 in regulating advanced glycosylation end products and advanced lipoxidation end products
a Y48F/H110F double mutant of AKR1B3 completely lost PGDS (zeige PTGDS Proteine) activity and showed only 2.9% of PGFS (zeige AKR1C3 Proteine) activity
Sequential catalysis of Aldr1 by glutathione S-transferase P (zeige GSTP1 Proteine) and glutaredoxin (zeige GRX1 Proteine) may be a general redox switching mechanism that regulates the reduction of protein sulfenic acids to cysteines regulates the reduction of protein sulfenic acids to cysteines
L-idose is the best alternative to D-glucose in studies on aldose reductase.
prostaglandin F synthase (zeige AKR1C3 Proteine) activity of human and bovine aldo-keto reductases
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
Lii5-2 CTCL tumor antigen
, aldehyde reductase 1
, aldo-keto reductase family 1 member B1
, aldose reductase
, low Km aldose reductase
, aldo-keto reductase family 1, member B1 (aldose reductase)
, Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)
, aldo-keto reductase family 1, member B4 (aldose reductase)
, 20-alpha-hydroxysteroid dehydrogenase
, aldehyde reductase