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Human Polyclonal AKR1B1 Primary Antibody für WB - ABIN513260
Hernández-Ochoa, Robison, Contreras, Shen, Zhao, Schneider: Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle. in Experimental biology and medicine (Maywood, N.J.) 2012
Human Monoclonal AKR1B1 Primary Antibody für IHC (p), ELISA - ABIN513262
Ebert, Kisiela, Wsól, Maser: Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. in Chemico-biological interactions 2011
Human Polyclonal AKR1B1 Primary Antibody für ICC, IF - ABIN4278953
Orton, Doucette, Maksym, MacLellan: Proteomic analysis of rat proximal tubule cells following stretch-induced apoptosis in an in vitro model of kidney obstruction. in Journal of proteomics 2014
Human Polyclonal AKR1B1 Primary Antibody für IHC, WB - ABIN4890159
Steuber, Heine, Podjarny, Klebe: Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features. in Journal of molecular biology 2008
Human Polyclonal AKR1B1 Primary Antibody für IF, IHC (p) - ABIN389205
Gleissner, Sanders, Nadler, Ley: Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis. in Arteriosclerosis, thrombosis, and vascular biology 2008
Show all 3 Pubmed References
Structure of ALR1 in ternary complex with NADPH and 3,5-dichlorosalicylic acid is reported as well as the implications for inhibitor binding and selectivity.
L-idose is the best alternative to D-glucose in studies on aldose reductase.
prostaglandin F synthase (zeige AKR1C3 Antikörper) activity of human and bovine aldo-keto reductases
Aldehyde reductase exerts a protective effect against carbon tetrachloride-induced hepatic steatosis by replenishing ascorbic acid via its antioxidative properties.
Aldose reductase acts as a switch which can regulate microglia by polarizing cells after spinal cord injury.
Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53 (zeige TP53 Antikörper).
Data indicate that inhibition of AR alleviates the MCD (zeige MLYCD Antikörper) diet-induced liver inflammation and fibrosis in db/db (zeige LEPR Antikörper) mice, probably through dampening CYP2E1 (zeige CYP2E1 Antikörper) mediated-oxidative stress and ameliorating the expression of pro-inflammatory cytokines.
FMHM suppressed the activity of AR-dependent phospholipase C (zeige PLC Antikörper)/protein kinase C (zeige PKC Antikörper) signaling, which further resulted in downstream inactivation of the IkappaB kinase (zeige CHUK Antikörper)/IkappaB/nuclear factor-kappa B inflammatory pathway.
Allergen-induced airway remodeling is mediated by AR and its inhibition blocks the progression of remodeling via inhibiting TGFbeta1 (zeige TGFB1 Antikörper)-induced Smad (zeige SMAD1 Antikörper)-independent and PI3K/AKT (zeige AKT1 Antikörper)/GSK3beta (zeige GSK3b Antikörper)-dependent pathway.
BGG-mediated inhibition of aldose reductase prevented LPS (zeige TLR4 Antikörper)-induced activation of JNK (zeige MAPK8 Antikörper).
The crystal structure of AKR1a4 in its apo (zeige C9orf3 Antikörper) form at high resolution.
crystal of AKR1B3 was tetragonal, belonging to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 107.62, c = 120.76 A
the role of AKR1B3 in regulating advanced glycosylation end products and advanced lipoxidation end products
An meta-analysis showed that aldose reductase C-106T variants appear to influence the risk for diabetic retinopathy in Chinese Han persons (meta-analysis).
AKR1B1 as a key modulator of tumor aggressiveness and suggests that pharmacologic inhibition of AKR1B1 has the potential to become a valuable therapeutic strategy for Basal-like breast cancer (BLBC).
Result indicate that the differential scanning fluorimetry (DSF) method is useful for enzyme inhibitor drug screening for the AKR superfamily, including AKR1B10 (zeige AKR1B10 Antikörper) and a structurally similar isoform AKR1B1.
The hyperosmotic AR gene expression was dependent on activation of metalloproteinases, autocrine/paracrine TGF-beta (zeige TGFB1 Antikörper) signaling, activation of p38 MAPK (zeige MAPK14 Antikörper), ERK1/2 (zeige MAPK1/3 Antikörper), and PI3K (zeige PIK3CA Antikörper) signal transduction pathways, and the transcriptional activity of NFAT5 (zeige NFAT5 Antikörper).
Aberrant DNA methylation (zeige HELLS Antikörper) of AKR1B1 could be potential screening markers of colorectal cancer.
-106T allele of AKR1B1 C-106T polymorphism may be associated with increased risk for essential hypertension in Chinese Han population.
These findings suggest a statistically significant association of AKR1B1 -106C>T polymorphism with retinopathy in North Indian patients
ALR (zeige GFER Antikörper) C(-106)T polymorphism was not associated with an increased risk of Diabetic Retinopathy; subgroup analysis showed a genetic association between ALR (zeige GFER Antikörper) C(-106)T polymorphism and the risk of Diabetic Retinopathy of type 1 Diabetes but not Diabetic Retinopathy of type 2 Diabetes(Meta-Analysis)
Higher expression of PLA2G2A (zeige PLA2G2A Antikörper), PTGS2 (zeige PTGS2 Antikörper), AKR1B1, AKR1C3 (zeige AKR1C3 Antikörper) and ABCC4 (zeige ABCC4 Antikörper) was seen in 22-B endometriosis cells.
Data conclude that AKR1B1 and TM6SF1 may serve as candidate methylation biomarkers for early breast cancer detection.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
aldo-keto reductase family 1, member B1-like
, aldose reductase
, aldo-keto reductase family 1, member B1 (aldose reductase)
, alcohol dehydrogenase
, alcohol dehydrogenase [NADP(+)]
, aldehyde reductase
, aldo-keto reductase family 1 member A1
, aldo-keto reductase family 1, member A4 (aldehyde reductase)
, 3-DG-reducing enzyme
, Lii5-2 CTCL tumor antigen
, aldehyde reductase 1
, aldo-keto reductase family 1 member B1
, low Km aldose reductase
, 20-alpha-hydroxysteroid dehydrogenase
, Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)
, aldo-keto reductase family 1, member B4 (aldose reductase)