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Study shows that alpha melanocyte stimulating hormone (zeige POMC Proteine) and forkhead box C2 protein promote fatty acid oxidation through C/EBPbeta (zeige CEBPB Proteine) negative transcription in mice adipose tissue.
Our findings demonstrate alphaMSH (zeige POMC Proteine) plays a key role in the prevention of adipose inflammation and inflammatory diseases by down-regulating Akt (zeige AKT1 Proteine)/JNK (zeige MAPK8 Proteine) signal pathway and negatively interacting with FoxOs, which brings up alphaMSH (zeige POMC Proteine) as a novel candidate factor in the adipose anti-inflammation process in obesity.
Data indicate the regulation of energy balance in BMPR1A (zeige BMPR1A Proteine)-mediated appetite regulation in POMC (zeige POMC Proteine) neurons.
POMC (zeige POMC Proteine) and AgRP (zeige AGRP Proteine) neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1 (zeige KISS1 Proteine)(ARC (zeige NOL3 Proteine)) neurons in male mice
Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC (zeige POMC Proteine)-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.(
disruption of this hippocampal POMC (zeige POMC Proteine)/MC4R (zeige MC4R Proteine) circuit might contribute to synaptic dysfunction observed in Alzheimer's disease.
The data show that somatic MORs in POMC (zeige POMC Proteine) neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
These findings indicate that the relevance of AgRP (zeige AGRP Proteine) to POMC (zeige POMC Proteine) neuron GABA connectivity depends on the state of AgRP (zeige AGRP Proteine) neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
these data unmasked a role for mitochondrial fission in leptin (zeige LEP Proteine) sensitivity and glucose sensing of POMC (zeige POMC Proteine) neurons.
it is suggested that the suppression of NeuroD1 (zeige NEUROD1 Proteine) expression and the inhibition of NeuroD1 (zeige NEUROD1 Proteine)/E-box interaction may play an important role in the Gc-mediated negative regulation of Pomc (zeige POMC Proteine).
In both melanoma cell lines, alphaMSH (zeige POMC Proteine) determined the reduction of proliferation through the PI(4,5)P2/PLC (zeige HSPG2 Proteine) pathway, employing PPARgamma (zeige PPARG Proteine) as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma.
The human beta-endorphin (zeige POMC Proteine) amyloid was studied in detail, exploiting solid-state NMR spectroscopy and TEM (zeige CYLD Proteine) analyses.
POMC (zeige POMC Proteine) and MC1R (zeige MSHR Proteine) were significantly lower in vitiligo (zeige MITF Proteine) lesional skin than in non-lesional skin as well as in controls and they were significantly higher in non-lesional skin than in the skin of the controls.
POMC (zeige POMC Proteine) has played an extraordinary role in the development of molecular endo-crinology and has clearly not yet given up all its secrets.
E2F1 (zeige E2F1 Proteine)-mediated hPOMC transcription is a potential target for suppressing ACTH (zeige POMC Proteine) production in ectopic Cushing's syndrome.
Elevated ACTH (zeige POMC Proteine) secretion is associated with Cushing's syndrome.
a novel p53 (zeige TP53 Proteine)/POMC (zeige POMC Proteine)/Galphas (zeige GNAS Proteine)/SASH1 (zeige SASH1 Proteine) autoregulatory positive feedback loop is regulated by SASH1 (zeige SASH1 Proteine) mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin (zeige FN1 Proteine) in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF (zeige TNF Proteine), IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine)) in such synoviocyte cultures.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1 (zeige POU1F1 Proteine), SF-1 (zeige NR5A1 Proteine), and ACTH (zeige POMC Proteine).
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (zeige MC4R Proteine)), pro-opiomelanocortin (POMC (zeige POMC Proteine)), apolipoprotein E (APOE (zeige APOE Proteine)) and agouti-related protein (AGRP (zeige AGRP Proteine)) with obesity in the North Indian population.
The association has been reported between polymorphisms of the CRH (zeige CRH Proteine) and POMC (zeige POMC Proteine) genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin (zeige POMC Proteine) was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC (zeige POMC Proteine) c.288C>T with start-of-finishing weight (SOF (zeige GJA1 Proteine) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (zeige PHB2 Proteine); P = 0.03) and marbling
The polymorphism of POMC (zeige POMC Proteine) gene is associated with the growth traits of Nanyang cattle.
The expression of the genes coding for proopiomelanocortin (POMC (zeige POMC Proteine)), proenkephalin (PENK (zeige PENK Proteine)) and prodynorphin (PDYN (zeige PDYN Proteine)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, beta-melanocyte stimulating hormone