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anti-Human p38 Antikörper:
anti-Rat (Rattus) p38 Antikörper:
anti-Mouse (Murine) p38 Antikörper:
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Human Polyclonal p38 Primary Antibody für IHC, WB - ABIN6714309
Li, He, Feng, Zhang, Tang, Bian, Bai, Zhou, Jiang, Heximer, Qin, Huang, Liu, Huang: Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 21 Pubmed References
Human Polyclonal p38 Primary Antibody für IHC, WB - ABIN6711591
Xu, Zheng, Xu, Yin, Qi, Xu, Han, Peng: Protective effects of dioscin against alcohol-induced liver injury. in Archives of toxicology 2015
Show all 18 Pubmed References
Human Polyclonal p38 Primary Antibody für IF (cc), IF (p) - ABIN671241
Li, Dong, Song, Xu, Liu, Song: Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling. in Chemico-biological interactions 2014
Show all 12 Pubmed References
Human Polyclonal p38 Primary Antibody für IHC, WB - ABIN6713301
Qin, Zhu, Ji, Chunmei-Shi, Kou, Zhu, Zhang, Wang, Ni, Guo: Monoclonal antibody to six transmembrane epithelial antigen of prostate-4 influences insulin sensitivity by attenuating phosphorylation of P13K (P85) and Akt: possible mitochondrial mechanism. in Journal of bioenergetics and biomembranes 2011
Show all 9 Pubmed References
Human Polyclonal p38 Primary Antibody für IF, IHC - ABIN6713300
Xiao, Moon, Yan, Nian, Zhang, Liu, Lu, Guan, Chen, Jiang, Jiang, Liu, Li: Cellular FLICE-inhibitory protein protects against cardiac remodelling after myocardial infarction. in Basic research in cardiology 2012
Show all 8 Pubmed References
Human Polyclonal p38 Primary Antibody für ELISA, ICC - ABIN6267706
Liu, Zheng, Zhang, Wang, Yang, Bai, Dai: Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells. in Neurochemical research 2017
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Human Polyclonal p38 Primary Antibody für IF (p), IHC (p) - ABIN710141
Zhao, Liu, Liu, Han, Zhao: Betulin attenuates lung and liver injuries in sepsis. in International immunopharmacology 2015
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Human Polyclonal p38 Primary Antibody für ELISA, ICC - ABIN6263958
Zou, Xiang, Wang, Peng, Wei: Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model. in BioMed research international 2017
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Human Monoclonal p38 Primary Antibody für ICS - ABIN1177122
Brunet, Pouysségur: Identification of MAP kinase domains by redirecting stress signals into growth factor responses. in Science (New York, N.Y.) 1996
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Human Polyclonal p38 Primary Antibody für IHC, IHC (p) - ABIN152964
Ito, Miyado, Nakagawa, Muraki, Imai, Yamakawa, Qin, Hosoi, Saito, Takahashi: Age-associated changes in the subcellular localization of phosphorylated p38 MAPK in human granulosa cells. in Molecular human reproduction 2010
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High MAPK14 expression is associated with hepatocellular carcinoma.
Subjecting cultured satellite cells to transient inhibition of P38alpha MAP kinase in conjunction with NAC treatment leads to their rapid expansion, with striking improvement of their regenerative potential in grafting experiments.
High MAPK14 expression is associated with Breast Cancer.
p38-mediated phosphorylation at threonine 367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis.
High expression of p38MAPK is associated with diabetic cataract.
p38 capital EM, Cyrilliccapital A, Cyrilliccapital ER, Cyrilliccapital KA, Cyrillic participates in the pathogenesis of epithelial-to-mesenchymal transition through Wnt pathway.
The Cox proportional hazard models revealed that IL12Rb2 and p38MAPK predicted a long OS. To the best of our knowledge, the present study is the first to reveal a close association between IL12Rb2 and p38MAPK, and their possible function in nonsmall cell lung cancer progression
Data show that miR-625-3p induces oxaliplatin resistance by abrogating MAP2K6-p38-regulated apoptosis and cell cycle control networks.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38/TRAF-6/ERK MAP kinases pathways has been reported.
The cytotoxicity induced by EB1 gene knockdown was due to the activation and generation of reactive oxygen species by p38 mitogen-activated protein kinase..this signaling cascade, however not nuclear factor-kappaB-mediated signaling, induced the expression of cyclooxygenase-2, a key effector of apoptotic death.
Data, including data using network analysis, suggest that angiotensinogen (AGT), mitogen-activated protein kinase-14 (MAPK14), and prothrombin (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
The role of p38 MAP kinase signaling in metastatic clear cell renal cell carcinoma
Rhythmic luciferase activity from clock gene luciferase reporter cells lines was used to test the effect of p38 MAPK inhibition on clock properties as determined using the damped sine fit and Levenberg-Marquardt algorithm.Glioma treatment with p38 MAPK inhibitors may be more effective and less toxic if administered at the appropriate time of the day.
Hsp27 and P38MAPK could be used as prognostic factors in Esophageal squamous cell carcinoma.
High p38MAPK expression is associated with non-small cell lung cancer metastasis.
when the cells were treated with SB203580, an inhibitor of the p38 MAPK pathway, the osteogenic effects of Epo on hPDLSCs and pPDLSCs were attenuated. In conclusion, Epo may upregulate the bone formation ability of hPDLSCs and pPDLSCs via the p38 MAPK pathways
p38alpha and ATF2 expression play a crucial role in the malignant phenotypes of ovarian tumor cells and are a markers of poor prognosis in patients with ovarian serous adenocarcinomas.
KLF4 overcomes tamoxifen resistance by suppressing MAPK signaling pathway and predicts good prognosis in breast cancer.
These results suggest that PYP treatment had a preventive effect on nephrotoxicity, specifically by downregulating the MAPK and NFkappaB signaling pathways and the mRNA levels of inflammatory genes
hepatic p38alpha MAPK functions as a negative regulator of liver steatosis in maintaining hepatic bile acid synthesis and fatty acid beta-oxidation by antagonizing the c-Jun N-terminal kinase (JNK).
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase-PKCalpha-p(38)MAPK and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 expression in the cells
cross-talk between p(38)MAPK and Gialpha play a pivotal role for full activation of cPLA2 during ET-1 stimulation of pulmonary artery smooth muscle cells.
MAPK14 signalling pathway is largely involved in heat-induced sperm damage.
p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.
Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.
p38 phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data suggest that the p38 and JNK signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter involves activation of p38 and JNK MAPKs
These data suggest a differential requirement of JNK1 and p38 MAPK in TNF regulation of E2F1. Targeted inactivation of JNK1 at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF-mediated EC dysfunction.
p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.
involvement of p38 MAP kinase activities and caldesmon phosphorylation in the MLCK-independent regulation of thrombin-induced endothelial cell permeability.
involvement of p38 MAP kinase in the hyaluronan oligosaccharide induction of MMP-13
These data indicate that early transient activation of MAPK-p38 in bovine mononuclear phagocytes by Mycobacterium avium subsp. paratuberculosis (MAP) organisms may be a key to the capacity of MAP to survive in bovine monocytes.
Replacement of distention with pharmacological relaxation reduced the increase in p38 expression, but not extracellular signal-regulated kinases.
dynamic compression stimulates cell proliferation and proteoglycan synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis.
Even in the presence of increased XIAP expression, inhibition of the mitogen-activated protein kinase (MAPK) p38 and MAPK-activated protein kinase 2 (MK2) made differentiated macrophages susceptible to cell death.
In conclusion, the activation of JNK and p38 after cerebral ischemia caused an increase in cerebral SGLT-1. The regulation of cerebral SGLT-1 expression via the MAPK pathway may be a novel therapeutic strategy for cerebral ischemia patients.
blocking p38 MAPK signaling through the inhibitor SB203580 significantly suppressed the acute lung injury and excessive lung inflammation in vivo, consistent with the reduced expression of the NLRP3 inflammasome and IL1beta and cleavage of caspase1.
results define a key role for p38alpha in luminal progenitor cell fate that affects mammary tumor formation.
Lysosomal p38 MAPK directly phosphorylates LAMP2A at T211 and T213, which causes its membrane accumulation and active conformational change, activating chaperone-mediated autophagy.
Results implicate neuronal p38alpha signaling in the synaptic plasticity dysfunction and memory impairment observed in 5XFAD mice, by regulating both amyloid-beta deposition in the brain and the relay of this accumulation to mount an inflammatory response, which leads to the cognitive deficits.
These findings uncovered the molecular mechanisms by which p38alpha MAPK regulates osteoclastogenesis and coordinates osteoclastogenesis and osteoblastogenesis.
Praja1 promotes skeletal myogenesis through degradation of EZH2 upon p38alpha activation.
These results suggested that the thrombinstimulated synthesis of IL6 was limited by HSP90 in osteoblasts, and that the effects of HSP90 were exerted at the point between Rhokinase and p38 MAPK.
Overall, the authors showed that CCN1 increased IL-1beta production via p38 MAPK signaling, indicating a role for CCN1 protein in regulating inflammation in psoriasis.
we have identified novel interaction between p38 MAPK and Runx2 enhances Runx2 transactivity, thus promoting vascular smooth muscle cells calcification
p38alpha MAPK maintains the expression of antioxidant genes in liver of young animals via NF-kappaBeta under basal conditions, whereas its long-term deficiency triggers compensatory up-regulation of antioxidant enzymes through NF-kappaBeta.
the present findings suggested that artesunate may exert protective effects against cerebral ischemia/reperfusion injury through the suppression of oxidative and inflammatory processes, via activating Nrf2 and downregulating ROSdependent p38 MAPK in mice.
Results show that the p38 MAPK signaling pathway could regulate mitochondria Abeta internalization by manipulating the expression of alpha7nAChR. Pretreatment of alpha7nAChR agonist could attenuate these biochemical changes which are tightly associated with Abeta1-42 induced apoptosis. Suggesting there is an endogenous, previously unrecognized cholinergic mechanism to control mitochondria functions and their apoptotic ...
Prdx1 knockout can aggravate the oxidative stress and lung injury by increasing the level of Reactive Oxygen Species (ROS), and also activate P38/JNK signaling pathway.
P38 kinase role in the inflammatory pain.CXCL13, upregulated by peripheral inflammation, acts on CXCR5 on dorsal root ganglia neurons and activates p38, which increases Nav1.8 current density and further contributes to the maintenance of inflammatory pain.
these findings indicate that BMS309403 reduces fatty acid-induced ER stress-associated inflammation in skeletal muscle by reducing p38 MAPK activation.
report insulin-like growth factor-II binding protein 1 (IGF2BP1) as a novel interacting partner of p38 MAPK.
These results were supported by the opposite outcomes observed for cells treated with A779 or DX600. Therefore, it was concluded that the ACE2-Ang(17)-Mas axis significantly inhibits pancreatitis by inhibition of the p38 MAPK/NF-kappaB signaling pathway
P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
Adult zebrafish cardiomyocytes express active p38alpha MAPK, which is switched off upon entry into mitosis.
Dkk3r regulates p38a phosphorylation to maintain Smad4 stability, in turn enabling the Smad2.Smad3a.Smad4 complex to form and activate the myf5 promoter.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Csaids binding protein
, MAP kinase 14
, MAP kinase 2
, MAP kinase Mxi2
, MAP kinase p38 alpha
, MAPK 14
, MAX-interacting protein 2
, cytokine suppressive anti-inflammatory drug binding protein
, cytokine-supressive anti-inflammatory drug binding protein
, mitogen-activated protein kinase 14
, mitogen-activated protein kinase 14A
, mitogen-activated protein kinase p38 alpha
, p38 MAP kinase
, p38 mitogen activated protein kinase
, p38alpha Exip
, reactive kinase
, stress-activated protein kinase 2A
, cytokine suppressive anti-inflammatory drug binding protein 1
, mitogen activated protein kinase 14
, p38 MAP kinase alpha
, p38 MAPK
, p38 alpha
, tRNA synthetase cofactor p38
, MAP kinase 14A
, MAP kinase p38a
, MAPK 14A
, Mitogen-activated protein kinase p38a
, mitogen-activated protein kinase p38a