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Metformin sensitizes arsenic trioxide to suppress intrahepatic cholangiocarcinoma via the regulation of AMPK (zeige PRKAA1 Proteine)/p38 MAPK (zeige MAPK14 Proteine)-ERK3 (zeige MAPK4 Proteine)/mTORC1 pathways. ERK3 (zeige MAPK4 Proteine) is a newfound potential prognostic predictor and a tumor suppressor in ICC.
Study revealed a post-translational regulation of TDP2 (zeige TDP2 Proteine) activity and discovered a new role of ERK3 (zeige MAPK4 Proteine) in increasing cancer cells' DNA damage response and chemoresistance to Top2 (zeige TOP2A Proteine) inhibitors.
MAPK6 could rescue the cell growth induced by miR499a and HBV
ERK3 (zeige MAPK4 Proteine) regulates endothelial cell migration, proliferation and tube formation by upregulating SRC-3 (zeige NCOA3 Proteine)/SP-1 (zeige PSG1 Proteine)-mediated VEGFR2 (zeige KDR Proteine) expression.
These findings further expand distinct roles of cyclin D3 (zeige CCND3 Proteine) and suggest the potential activity of ERK3 (zeige MAPK4 Proteine) in cell proliferation.
Cdc14A (zeige CDC14A Proteine) forms a stable complex with atypical mitogen-activated protein kinase (zeige MAPK1 Proteine) Erk3 (zeige MAPK4 Proteine) in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain.
identify the Erk3 (zeige MAPK4 Proteine) protein as a novel class I Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK (zeige MAPK1 Proteine) signaling.
A previously unknown role for ERK3 (zeige MAPK4 Proteine) in promoting lung cancer cell invasiveness by phosphorylating SRC-3 (zeige NCOA3 Proteine) and regulating SRC-3 (zeige NCOA3 Proteine) proinvasive activity by site-specific phosphorylation.
ERK3 (zeige MAPK4 Proteine) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular signal-regulated kinase 3 (ERK3) is conjugated to ubiquitin via its free NH(2) terminus, and that N-terminal tags stabilize expression of p21 (zeige CDKN1A Proteine) but not that of substrates ubiquitinated on internal lysine residues.
ERK3 (zeige RYK Proteine) biological activity is regulated by its cellular abundance through the control of protein stability
Data show that extracellular-regulated kinase 3 (ERK3 (zeige RYK Proteine)) specifically interacts with the MAPK-activated protein kinase 5 (MK5 (zeige MAPKAPK5 Proteine) or PRAK (zeige MAPKAPK5 Proteine)) in vitro and in vivo.
Results demonstrate a specific interaction between extracellular signal-regulated kinase 3 (ERK3) and mitogen-activated protein kinase-activated protein kinase-5 (MK5 (zeige MAPKAPK5 Proteine)).
p38gamma (zeige MAPK12 Proteine) MAP kinase (zeige MAPK1 Proteine) (SAPK3/p38gamma (zeige MAPK12 Proteine)) was shown to catalyse phosphorylation of SAP97 (zeige DLG1 Proteine).
Results show that Cdo (zeige CDO1 Proteine) is important for full Abl kinase activity, and Abl (zeige ABL1 Proteine) is necessary for full activation of p38 MAPK (zeige MAPK14 Proteine), during myogenic differentiation.
abscisic acid and jasmonate mediate inactivation of the immune-associated MAP kinases (MAPKs), MPK3 (zeige MAPK3 Proteine) and MPK6, in Arabidopsis thaliana ABA induced expression of genes encoding the protein phosphatases 2C (PP2Cs), HAI1 (zeige SPINT1 Proteine), HAI2 (zeige SPINT2 Proteine), and HAI3 through ABF/AREB transcription factors
Proteome changes associated with MPK4 (zeige MAPK4 Proteine) and MPK6 deficiency in Arabidopsis roots.
Results suggest that these mutants can be used to analyze the specific biological functions of MAP kinase 6 (MPK6).
These data highlight MPK6 and MKP1 (zeige DUSP1 Proteine) as components of an L-Glutamate (zeige GRIN2A Proteine) pathway linking the auxin response, and cell division for primary root growth.
Genetic and biochemical evidences not only show that MEK1 (zeige MAP2K1 Proteine)-MPK6 cascade, AtRBOHD/F-dependent H2O2 and NIA1-dependent NO are all involved in dark-induced stomatal closure in Arabidopsis, also indicate that MEK1 (zeige MAP2K1 Proteine)-MPK6 cascade functions via working downstream of H2O2 and upstream of NO.
that MPK3/MPK6 phosphorylate and destabilize ICE1, which negatively regulates CBF expression and freezing tolerance in plants
BASL polarization leads to elevated nuclear MPK6 signaling and lowered SPCH abundance in one of the two daughter cells. Therefore, two daughter cells are differentiated by BASL polarity-mediated differential suppression of SPCH, which may provide developmental plasticity in plant stem cell asymmetric cell division.
results indicated that AIK1-MKK5 (zeige MAP2K5 Proteine)-MPK6 functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (zeige MAPK1 Proteine) cascade.
MPK6 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3 (zeige MAPK3 Proteine)/MPK6 cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.
, MAP kinase 6
, MAP kinase isoform p97
, MAPK 6
, extracellular signal-regulated kinase 3
, extracellular signal-regulated kinase, p97
, protein kinase, mitogen-activated 5
, protein kinase, mitogen-activated 6
, Erk-3 related
, mitogen activated protein kinase 4
, mitogen activated protein kinase 6
, protein kinase, mitogen activated kinase 4
, extracellular related kinase 3
, mitogen-activated protein kinase 6