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LZK (zeige MAP3K13 Proteine) cooperates with DLK (zeige DAPK3 Proteine) to promote retinal ganglion cell death in response to axon injury.
REVIEW: Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase
miR (zeige MLXIP Proteine)-130a inhibited the JNK (zeige MAPK8 Proteine) pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of diabetic endothelial progenitor cell function.
Data suggest that specific pharmacological inhibition of dual leucine zipper kinase (DLK, MAP3K12) may have therapeutic potential in multiple indications of neuronal degeneration.
these findings indicate that DLK (zeige DAPK3 Proteine) participates in cell proliferation and/or survival, at least in part, by modulating the expression of cell cycle regulatory proteins.
The results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between ZIPK (zeige DAPK3 Proteine) expression and the clinical course of the disease.
the DLK (zeige DAPK3 Proteine)-ERK (zeige EPHB2 Proteine) signaling pathway may act as a regulator of the interaction that occurs between Hsp27 (zeige HSPB1 Proteine) and the cytoskeleton during the formation of the cornified cell envelope, a process conferring to the skin its crucial barrier function
for the selective expression of ZPK gene, cell-specific negative regulatory element(s) which locate outside of the core promoter region repress the potent basic promoter activity
ZIPK (zeige DAPK3 Proteine) is positively regulated by phosphorylation within its kinase domain and contains an inhibitory C-terminal domain that controls enzyme activity.
DLK (zeige DAPK3 Proteine) is a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification
These findings identify DLK as a central regulator of not only JNK but also PERK stress signaling in neurons, with both pathways contributing to neurodegeneration.
Results provide the first evidence that axon guidance genes are downstream targets of the dual leucine zipper kinase (DLK) signaling pathway, which through their regulation probably modulates neuronal cell development, structure and function.
the prevention of the nuclear localization of DLK (zeige DAPK3 Proteine) as induced by prediabetic signals with consecutive suppression of beta-cell apoptosis might constitute a novel target in the therapy of diabetes mellitus
Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK (zeige DAPK3 Proteine) does not appear to have a critical function in axonal degeneration; function appears restricted to soma
This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4 (zeige MAP2K4 Proteine)-dependent mechanism in axotomy-induced motoneuron death in neonates
DLK (zeige DAPK3 Proteine)-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures.
Abundance of DLK (zeige DAPK3 Proteine) in turn controlled the levels of downstream JNK (zeige MAPK8 Proteine) signaling and apoptosis.
DLK (zeige DAPK3 Proteine) is required for RGC JNK (zeige MAPK8 Proteine) activation and cell death in a rodent model of optic neuropathy
The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. DLK (zeige DAPK3 Proteine) is an essential upstream mediator of both of these divergent outcomes in the same cell type.
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
, dual leucine zipper bearing kinase
, dual leucine zipper kinase DLK
, leucine zipper protein kinase
, mixed lineage kinase
, protein kinase MUK
, Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase)
, Zipper (leucine) protein kinase
, dual leucine zipper kinase
, leucine-zipper protein kinase
, mitogen-activated protein kinase kinase kinase 12
, mitogen activated protein kinase kinase kinase 12
, zipper (leucine) protein kinase
, mitogen activated protein kinase kinase kinase 12 type A
, mitogen activated protein kinase kinase kinase 12 type B
, mitogen-activated protein kinase kinase kinase 12 L homeolog