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the p.Glu116Lys rare variant in MAP2K7 predisposes its carriers to develop COPD (zeige ARCN1 Proteine), which would provide a useful genetic biomarker for COPD (zeige ARCN1 Proteine) susceptibility in Chinese.
Combination BRAF (zeige BRAF Proteine) and MEK (zeige MAP2K1 Proteine) inhibition has also been shown to improve overall survival in patients with V600E-mutated melanoma. Responses to therapy are often rapid, and treatment is not associated with immune-related adverse events.
Our findings indicate that GADD45 (zeige GADD45A Proteine) essentially suppresses the MKK7-JNK (zeige MAPK8 Proteine) pathway and suggest that differentially expressed GADD45 (zeige GADD45A Proteine) family members fine-tune stress-inducible JNK (zeige MAPK8 Proteine) activity.
The latter insight is likely to promote the production of allosteric MAP2K7 inhibitors.
MEK activation cooperates with Cdkn2a and Pten inactivation to induce melanoma
MKK7 undergoes neddylation in human breast cancer cells
In an Eastern Chinese population, carriers of MAP2K7 rs3679T variant genotypes had an increased risk of NSCLC.
Therefore, EGF (zeige EGF Proteine) is suggested to induce E-cadherin (zeige CDH1 Proteine) down-regulation at the transcriptional level through the MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine) pathway, which might result in, at least in part, the induction of cellular morphological changes and cell migration in LoVo cells.
combined pan-RAF and MEK inhibition can overcome intrinsic and acquired resistance to single-agent RAF/MEK inhibition, supporting dual pan-RAF and MEK inhibition as a novel therapeutic strategy for BRAF- and KRAS-mutant cancers
our study suggested that black rice anthocyanins extract suppress metastasis in breast cancer cells by targeting the RAS/RAF (zeige RAF1 Proteine)/MAPK (zeige MAPK1 Proteine) pathway
High Map2k7 expression is associated with T-cell acute lymphoblastic leukemia.
The loss of mkk4 (zeige MAP2K4 Proteine) and mkk7 locks damaged exocrine cells in a permanently de-differentiated state.
Arrestin-3 (zeige ARRB2 Proteine) directly interacts with MKK7 and promotes JNK3alpha2 phosphorylation by both MKK4 (zeige MAP2K4 Proteine) and MKK7 in vitro as well as in intact cells.
MKK7 is specifically phosphorylated in the neurite shaft which triggers Map1b (zeige MAP1B Proteine) phosphorylation to regulate microtubule bundling leading to neurite elongation.
Data indicate that mitogen activated protein kinase kinase 7 (MKK7) plays a critical regulatory role in the c-Jun N-terminal kinase pathway in a murine model of rheumatoid arthritis.
a novel function for the stress kinase MKK7 as a regulator of the circadian clock in mammalian cells at steady state.
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
MKK4 (zeige MAP2K4 Proteine)/7 and JNK1 (zeige MAPK8 Proteine)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.
This study demonistrated that Stress-activated protein kinase (zeige CDK7 Proteine) MKK7 regulates axon elongation in the developing cerebral cortex.
The results reveal an essential role of MKK7 in cardiomyocytes for protecting the heart from hypertrophic insults thereby preventing the transition to heart failure.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
mitogen-activated protein kinase kinase 7
, JNK kinase 2
, JNK-activating kinase 2
, JNKK 2
, MAP kinase kinase 7
, MAPK/ERK kinase 7
, MAPKK 7
, MEK 7
, c-Jun N-terminal kinase kinase 2
, dual specificity mitogen-activated protein kinase kinase 7
, SAPK kinase 4
, stress-activated protein kinase kinase 4
, mitogen activated protein kinase kinase 7
, protein kinase, mitogen activated, kinase 7