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Human MAP2K5 Protein expressed in Wheat germ - ABIN1310183
García-Hoz, Sánchez-Fernández, Díaz-Meco, Moscat, Mayor, Ribas: G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). in The Journal of biological chemistry 2010
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When yeast genetic interaction partners held in common between human OPTN (zeige OPTN Proteine) and ANG (zeige ANG Proteine) were validated in mammalian cells and zebrafish, MAP2K5 kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy
For gain and loss of function studies, constitutively active MEK5 (CA-MEK5) and ERK5 (zeige MAPK7 Proteine) shRNA lentiviruses were used to activate or knock down extracellular signal-regulated kinase 5 (ERK5 (zeige MAPK7 Proteine)). Our results confirmed that low concentrations of H2O2 promoted HUVECs angiogenesis in vitro, and ERK5 (zeige MAPK7 Proteine) is an essential mediator of this process. Therefore, ERK5 (zeige MAPK7 Proteine) may be a potential therapeutic target for promoting angiogenesis
results confirmed the association of BTBD9 and MAP2K5/SKOR1 with primary Restless Legs Syndrome in Chinese population
Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression.
Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 (zeige STAT3 Proteine) augments breast cancer cell EMT (zeige ITK Proteine), which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 (zeige STAT3 Proteine) and MEK5/Erk5 (zeige MAPK7 Proteine) pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis.
Our findings confirm an association between the BTBD9, MEIS1, and MAP2K5/SKOR1 SNPs and periodic limb movements of sleep in an elderly cohort.
Specifically, CKS1B (zeige CKS1B Proteine) and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1 (zeige PACSIN1 Proteine), by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.
High MEK5 expression is associated with colorectal cancer.
SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China.
Periodic leg movements during sleep are associated with polymorphisms in BTBD9 (zeige BTBD9 Proteine), TOX3 (zeige TOX3 Proteine)/BC034767, MEIS1 (zeige MEIS1 Proteine), MAP2K5/SKOR1, and PTPRD (zeige PTPRD Proteine)
These results suggest that YAP (zeige YAP1 Proteine) promotes muscle differentiation by activating the Abl (zeige ABL1 Proteine)/Src (zeige SRC Proteine)/MEKK3 (zeige MAP3K3 Proteine)/MEK5/ERK5 (zeige MAPK7 Proteine) kinase cascade.
MEK5 overexpression inhibits differentiation of osteoblasts.
the MEK5-ERK5 (zeige MAPK7 Proteine) MAP kinase (zeige MAPK1 Proteine) signaling pathway has a critical role in BAFF (zeige TNFSF13B Proteine)-induced mature B cell survival and homeostatic maintenance of B2 cell numbers
The MEK5/ERK5 (zeige MAPK7 Proteine) pathway also mediates FSS-induced Runx-2 (zeige RUNX2 Proteine) expression in osteoblast differentiation.
finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression
PB1 (zeige GPR97 Proteine) domain mediates the association of MEKK2 (zeige MAP3K2 Proteine) and MEKK3 (zeige MAP3K3 Proteine) with MEK5 and that the respective PB1 (zeige GPR97 Proteine) domains of these kinases are critical for regulation of the ERK5 (zeige MAPK7 Proteine) pathway.
MEK5 is an activator of ERK5 (zeige MAPK7 Proteine) and an essential regulator of cell survival that is required for normal embryonic development
the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 (zeige MAPK7 Proteine) signaling pathway
MEK5 and big MAP kinase 1 (BMK1 (zeige MAPK7 Proteine)) function downstream of MEKK3 (zeige MAP3K3 Proteine) in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1 (zeige PPP3R1 Proteine)
A noncanonical function of Map2k5 domain is decribed for coordinated erk5 (zeige MAPK7 Proteine) kinase and map2k7 (zeige MAP2K7 Proteine) signaling.
The Arabidopsis MKK4 (zeige MAP2K4 Proteine)/MKK5-MPK6 (zeige MAPK6 Proteine) cascade is an important player in the maternal control of embryogenesis.
results indicated that AIK1-MKK5-MPK6 (zeige MAPK6 Proteine) functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (zeige MAPK1 Proteine) cascade.
AIK1-MKK5-MPK6 (zeige MAPK6 Proteine) cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
MKK4 (zeige MAP2K4 Proteine), MKK5, MKK7 (zeige MAP2K7 Proteine), and MKK9, are responsible for the activation of MPK3 (zeige MAPK3 Proteine) and MPK6 (zeige MAPK6 Proteine) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (zeige MAPK1 Proteine) signaling through MKK4 (zeige MAP2K4 Proteine)/5/7/9-MPK3 (zeige MAPK3 Proteine)/6 cascades.
Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6 (zeige MAPK6 Proteine), was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
our data indicate that EDR1 physically associates with MKK4 (zeige MAP2K4 Proteine)/MKK5 and negatively regulates the MAPK (zeige MAPK1 Proteine) cascade to fine-tune plant innate immunity.
Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 (zeige TGFB1 Proteine) as well as the activation of MKK5 activity were completely arrested.
Results suggest that the YDA-MKK4 (zeige MAP2K4 Proteine)/MKK5-MPK3 (zeige MAPK3 Proteine)/MPK6 (zeige MAPK6 Proteine) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
MKK5 functions both in ozone-induced activation of MPK3 (zeige MAPK3 Proteine) and MPK6 (zeige MAPK6 Proteine) and in integrating reactive oxygen species homeostasis during ozone stress.
MKK5 is a key regulator of stomatal development and patterning.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
MAP kinase kinase 5
, MAPK/ERK kinase 5
, MAPKK 5
, MEK 5
, dual specificity mitogen-activated protein kinase kinase 5
, mitogen-activated protein kinase kinase 5
, MAP kinase kinase MEK5b
, MAPK/ERK kinese 5
, mitogen activated protein kinase kinase 5