anti-Meerschweinchen MAP2K3 Antikörper für Western Blotting

Recommended MAP2K3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) Antikörper
  • Mkk3
  • MAPKK3
  • MEK3
  • MKK3
  • PRKMK3
  • SAPKK-2
  • SAPKK2
  • AW212142
  • Prkmk3
  • mMKK3b
  • map2k3
  • zMKK3
  • MAP kinase activator XMEK3
  • mitogen activated protein kinase kinase 3
  • mitogen-activated protein kinase kinase 3
  • mitogen-activated protein kinase kinase 6
  • map2k3
  • Map2k3
  • MAP2K3
  • map2k6
Epitop
C-Term
35
28
16
13
12
11
10
10
10
7
7
6
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Zebrafisch (Danio rerio)
330
167
154
55
39
5
4
4
3
2
1
1
1
1
Wirt
Kaninchen
225
105
Klonalität
Polyklonal
Konjugat
Dieser MAP2K3 Antikörper ist unkonjugiert
8
8
7
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
287
142
115
83
68
26
24
17
10
7
3
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN2777129
$ 289.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
2.8412423 ABIN2777128 IHC WB Rabbit N-Term Anmelden zum Anzeigen Polyclonal 1
1 ABIN320697 WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0

General

Antigen Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) Antikörper
Epitop C-Term
(35), (28), (16), (13), (12), (11), (10), (10), (10), (7), (7), (6), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Zebrafisch (Danio rerio)
(330), (167), (154), (55), (39), (5), (4), (4), (3), (2), (1), (1), (1), (1)
Wirt Kaninchen
(225), (105)
Klonalität
Polyklonal
Konjugat Dieser MAP2K3 Antikörper ist unkonjugiert
(8), (8), (7), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunohistochemistry (IHC), Western Blotting (WB)
(287), (142), (115), (83), (68), (26), (24), (17), (10), (7), (3), (1), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-MAP2K3 Antikörper

Target Details MAP2K3 Anwendungsinformationen Handhabung Referenzen für anti-MAP2K3 Antikörper (ABIN2777129) Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN979769.
Sequenz EEPSPQLPAD RFSPEFVDFT AQCLRKNPAE RMSYLELMEH PFFTLHKTKK
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Zebrafish: 100%
Produktmerkmale This is a rabbit polyclonal antibody against MAP2K3. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human MAP2K3
Plasmids, Primers & others

Target Details MAP2K3

Produktdetails anti-MAP2K3 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-MAP2K3 Antikörper (ABIN2777129) Bilder zurück nach oben
Antigen
Andere Bezeichnung MAP2K3 (MAP2K3 Antibody Abstract)
Hintergrund MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Alias Symbols: MAPKK3, MEK3, MKK3, PRKMK3, SAPKK2, SAPKK-2
Protein Interaction Partner: UBC, EGFR, MAPK14, MAP3K5, ARRB1, PKN1, ALDOC, APP, LRRK2, MAPK8IP2, MAPK8IP3, MAPK8IP1, SPAG9, MAP3K2, MAP2K3, PPP2R4, MAP3K4, MAP3K3, TINF2, MYC, RPL13, TAOK2, TAOK1, DCTN1, DYRK1B, PLCB2, SMAD7, MAPK12, MAPK3, ELK1, MAP2K6, NPHS1,
Protein Size: 318
Molekulargewicht 36 kDa
Gen-ID 5606
NCBI Accession NM_002756, NP_002747
Pathways MAPK Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling Events mediated by VEGFR1 and VEGFR2

Anwendungsinformationen

Produktdetails anti-MAP2K3 Antikörper Target Details MAP2K3 Handhabung Referenzen für anti-MAP2K3 Antikörper (ABIN2777129) Bilder zurück nach oben
Applikations-hinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 318 AA

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-MAP2K3 Antikörper Target Details MAP2K3 Anwendungsinformationen Referenzen für anti-MAP2K3 Antikörper (ABIN2777129) Bilder zurück nach oben
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MAP2K3 Antikörper (ABIN2777129)

Produktdetails anti-MAP2K3 Antikörper Target Details MAP2K3 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Prickett, Brautigan: "Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4217-27, 2007

Bilder

Produktdetails anti-MAP2K3 Antikörper Target Details MAP2K3 Anwendungsinformationen Handhabung Referenzen für anti-MAP2K3 Antikörper (ABIN2777129) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) (C-Term) antibody (ABIN2777129) WB Suggested Anti-MAP2K3 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Po...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) (C-Term) antibody (ABIN2777129) MAP2K3 antibody - C-terminal region Formalin Fixed Paraffin Embedded Tissue:...