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Report a synthetic lethal interaction of cetuximab in combination with MEK1 (zeige MAP2K1 Proteine)/2 inhibition for the NRAS (zeige NRAS Proteine) mutant subgroup of metastatic colorectal cancer.
There are no other biomarkers correlated with treatment responses following MEK1 (zeige MAP2K1 Proteine)/2 inhibition.
MEK2 was essential for the phosphorylation of MKK3 (zeige MAP2K3 Proteine)/MKK6 (zeige MAP2K6 Proteine) and p38 MAPK (zeige MAPK14 Proteine) that directly impacted on cyclin D1 (zeige CCND1 Proteine) expression.
High MEK2 expression is associated with inflammation.
there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (zeige ICAM1 Proteine)), ezrin (EZR (zeige EZR Proteine)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3 (zeige NANOS3 Proteine)) gene expressions in metabolic syndrome patients.
The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (zeige PTPN11 Proteine)) syndrome
Data show that mitogen-activated protein kinase (zeige MAPK1 Proteine) kinases MEK1 (zeige MAP2K1 Proteine)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.
the purpose of this paper was to investigate MAPK (zeige MAPK1 Proteine) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (zeige MAP2K1 Proteine)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (zeige MAP2K1 Proteine)/2
Endocytosis separates EGF (zeige EGF Proteine) receptors from endogenous fluorescently labeled HRas (zeige HRAS Proteine) and diminishes receptor signaling to MAP kinases in endosomes.
data suggest that, although short-term suppression of Mek1 (zeige MAP2K1 Proteine)/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
fluid shear stress induces autocrine TGF-beta (zeige TGFB1 Proteine)/ALK5 (zeige TGFBR1 Proteine)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (zeige MAP2K1 Proteine)/2-mediated signaling.
FGF2 (zeige FGF2 Proteine) is an extracellular inducer of COUP-TFII (zeige NR2F2 Proteine) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (zeige NR2F2 Proteine) expression prior to the onset of osteogenic differentiation
REDD1 (zeige DDIT4 Proteine) is required for normal insulin (zeige INS Proteine)-stimulated signaling, and a subtle balance exists between MEK1 (zeige MAP2K1 Proteine)/2, REDD1 (zeige DDIT4 Proteine), and mTOR (zeige FRAP1 Proteine)
MEK1 (zeige MAP2K1 Proteine) and MEK2 can substitute for each other but a minimum amount of MEK (zeige MDK Proteine) is critical for placenta development and embryo survival
MK2 (zeige KCNA2 Proteine)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
MK2 (zeige KCNA2 Proteine) attenuates dendritic cell-mediated Th1 (zeige HAND1 Proteine) differentiation and autoimmune encephalomyelitis.
analysis of p38 (zeige CRK Proteine)-MK2 (zeige KCNA2 Proteine)-activated Rsk (zeige RPS6KA1 Proteine) signaling in toll (zeige TLR4 Proteine)-like receptor-stimulated dendritic cells
both MEK1 (zeige MAP2K1 Proteine) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract
the AtMKK2-AtMPK10 (zeige MAPK10 Proteine) MAPK (zeige MAPK1 Proteine) module regulates leaf venation complexity by altering polar auxin transport efficiency
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (zeige MAPK4 Proteine) activation concomitantly with MEKK1 (zeige MAP3K1 Proteine) and MKK2 phosphorylation.
Ca(2 (zeige CA2 Proteine)+) signaling occurred upstream of the MEKK1 (zeige MAP3K1 Proteine)-MKK2 pathway. MEKK1 (zeige MAP3K1 Proteine) was phosphorylated by calcium/calmodulin-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (zeige MAP3K1 Proteine).
Data indicate that MEKK2 (zeige MAP3K2 Proteine) is required for the mekk1 (zeige MAP3K1 Proteine), mkk1 (zeige MAP2K1 Proteine) mkk2, and mpk4 (zeige MAPK4 Proteine) autoimmune phenotypes.
Data suggest that the MEKK1 (zeige MAP3K1 Proteine)-MKK1 (zeige MAP2K1 Proteine)/MKK2-MPK4 (zeige MAPK4 Proteine) kinase cascade negatively regulates MEKK2 (zeige MAP3K2 Proteine) and activation of MEKK2 (zeige MAP3K2 Proteine) triggers SUMM2-mediated immune responses.
Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.
double loss-of-function mutant (mkk1 (zeige MAP2K1 Proteine)/2) of MKK1 (zeige MAP2K1 Proteine) and MKK2 is shown to have marked phenotypes in development and disease
Activation of MPK4 (zeige MAPK4 Proteine) by flg22 is impaired in the mkk1 (zeige MAP2K1 Proteine) mkk2 double mutants, suggesting that MKK1 (zeige MAP2K1 Proteine) and MKK2 function together with MPK4 (zeige MAPK4 Proteine) and MEKK1 (zeige MAP3K1 Proteine) in a MAP kinase (zeige MAPK1 Proteine) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
ERK activator kinase 2
, MAP kinase kinase 2
, MAPK/ERK kinase 2
, MAPKK 2
, MEK 2
, dual specificity mitogen-activated protein kinase kinase 2
, mitogen-activated protein kinase kinase 2, p45
, MAP kinase/Erk kinase
, mitogen activated protein kinase kinase 2
, protein kinase, mitogen activated, kinase 2, p45
, dual specificity mitogen activated protein kinase kinase 2
, mitogen-activated protein kinase kinase type 2