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Human JNK Protein expressed in Wheat germ - ABIN1310303
Prause, Christensen, Billestrup, Mandrup-Poulsen: JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. in PLoS ONE 2014
Human JNK Protein expressed in Baculovirus infected Insect Cells - ABIN593493
Sury, McShane, Hernandez-Miranda, Birchmeier, Selbach et al.: Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU ... in Molecular & cellular proteomics : MCP 2015
Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun (zeige JUN Proteine).
Inhibition of each TGFbeta (zeige TGFB1 Proteine) receptor-I, glucocorticoid receptor (zeige NR3C1 Proteine) or JNK signaling partially reversed the dexamethasone-mediated effects, suggesting a complex signaling network. These data reveal that dexamethasone mediates progression by membrane effects and binding to glucocorticoid receptor (zeige NR3C1 Proteine)
JNK inhibitor prevents SIRT1 (zeige SIRT1 Proteine) phosphorylation, leading to elevated SIRT1 (zeige SIRT1 Proteine) protein levels even in the presence of H2O2. Taken together, our results indicate that CHFR (zeige CHFR Proteine) plays a crucial role in the cellular stress response pathway by controlling the stability and function of SIRT1 (zeige SIRT1 Proteine).
Findings suggest that during lipoapoptosis, HCV infection may enhance hepatocyte toxicity by increasing JNK phosphorylation.
High JNK expression is associated with non-small-cell lung cancer.
These data suggested that Annexin A2 (zeige ANXA2 Proteine) induces cisplatin resistance of non-small cell lung cancer (NSCLC)via regulation of JNK/c-Jun/p53 (zeige TP53 Proteine) signaling, and provided an evidence that blockade of Annexin A2 (zeige ANXA2 Proteine) could serve as a novel therapeutic approach for overcoming drug resistance in NSCLCs
Data suggest that H2O2 regulates cell death in granulosa cells via the ROS (zeige ROS1 Proteine)-JNK-p53 (zeige TP53 Proteine) pathway.
High expression of JNK is associated with invasion of gastric cancer.
JNK activation and signaling in extrahepatic cholangiocarcinoma is regulated by L1CAM.JNK role in cell migration in extrahepatic cholangiocarcinoma.
Thus, the present study indicated that parkin (zeige PARK2 Proteine) knockout inhibits neural stem cell differentiation by JNK-dependent proteasomal degradation of p21 (zeige CDKN1A Proteine).
Findings indicate the MIG-15/JNK-1 pathway can restrict both glutamatergic synapse formation and short-term learning.
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (zeige INS Proteine)-IGF-1 (zeige IGF1 Proteine) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) signaling pathway, which is regulated by MLK-1 (zeige MAP3K9 Proteine) MAPK (zeige MAPK1 Proteine) kinase kinase (MAPKKK), MEK-1 (zeige MAP2K1 Proteine) MAPK (zeige MAPK1 Proteine) kinase (MAPKK), and KGB-1 (zeige KCNJ3 Proteine) JNK-like MAPK (zeige MAPK1 Proteine).
Data identify a unique signal crosstalk between Wnt (zeige WNT2 Proteine) signaling and the MAP3K1 (zeige MAP3K1 Proteine)-JNK pathway in epithelial morphogenesis.
Therefore, APP (zeige APP Proteine) modulates Nav1.6 (zeige SCN8A Proteine) sodium channels through a Go-coupled JNK pathway, which is dependent on phosphorylation of APP (zeige APP Proteine) at Thr668.
These interactions are required for SRC (zeige SRC Proteine)-induced activation of VAV (zeige VAV1 Proteine) and the subsequent engagement of a JIP1 (zeige MAPK8IP1 Proteine)-tethered JNK signaling module.
this study establishes that JNK1 is a key mediator of osteoblast function in vivo and in vitro.
Jnk1 deficiency inhibits the development of neural stem cells/precursors
Suppressing P38 (zeige CRK Proteine) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
transgenic mice overexpressing sPLA2 -IIA (zeige PLA2G2A Proteine) keratinocytes showed enhanced activation of EGFR (zeige EGFR Proteine) and JNK1/2 that led to c-Jun (zeige JUN Proteine) activation.
p53 (zeige TP53 Proteine) plays a novel protective role in APAP induced liver injury through inhibiting the activation of JNK, a key mediator in APAP-induced oxidative stress.
Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) activation was suppressed by fusion-inducing JNK signaling.
aken together, these results reveal that inactivation of Rpd3 (zeige HDAC1 Proteine) independently regulates JNK and Yki (zeige YAP1 Proteine) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (zeige HDAC1 Proteine) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (zeige EGFR Proteine)) pathway in the lateral epidermis for sustained dpp (zeige TGFb Proteine) expression in the LE. Specifically, we demonstrate that Egfr (zeige EGFR Proteine) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS (zeige ETS1 Proteine)-domain factor Ets21c and the nuclear receptor Ftz-F1 (zeige NR5A2 Proteine), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (zeige ROS1 Proteine)/JNK/p38 (zeige MAPK14 Proteine)/Upd (zeige UROD Proteine) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (zeige NOTCH1 Proteine)-Src (zeige SRC Proteine) synergy.
This study demonstrated that the mechanism by which Bsk (zeige FRK Proteine) is required for pruning is through reducing the membrane levels of the adhesion molecule (zeige NCAM1 Proteine) Fasciclin II (zeige NCAM2 Proteine) (FasII)
Porcine reproductive and respiratory syndrome virus -activated TAK-1 (zeige NR2C2 Proteine) was essential for the activation of JNK and NF-kappaB (zeige NFKB1 Proteine) pathways and IL-8 (zeige IL8 Proteine) expression.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1/2 dependent.
These data suggest that the p38 (zeige MAPK14 Proteine) and JNK signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
based on the data, we can conclude that JNK plays an active role in fragmentation of pig oocytes and that p38 MAPK (zeige MAPK14 Proteine) is not involved in this process
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.
PP2A (zeige PPP2R2B Proteine) and AIP1 (zeige PDCD6IP Proteine) cooperatively induce activation of ASK1 (zeige MAP3K5 Proteine)-JNK signaling and vascular endothelial cell apoptosis.
Phorbol 12-myristate 13-acetate activation of ERK (zeige MAPK1 Proteine) and JNK signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
study reports MPK8 connects protein phosphorylation, Ca(2 (zeige CA2 Proteine))+ and ROS (zeige ROS1 Proteine) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (zeige CA2 Proteine))+/CaMs and MAP kinase (zeige MAPK1 Proteine) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (zeige ROS1 Proteine) homeostasis
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (zeige CASP3 Proteine)-dependent Proteolysis of JNK1-2 and Bid (zeige BID Proteine).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (zeige GUSB Proteine).
Data show that the death pathway is independent of ERK (zeige MAPK1 Proteine) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (zeige CDK1 Proteine) and JNK.
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (zeige MAPK14 Proteine) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (zeige AXIN1 Proteine)/JNK signaling and its inhibitor Aida (zeige AIDA Proteine) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (zeige MMP13 Proteine) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Suggest that hypoxia-induced modified cells engage the PDGFbeta-R-JNK1 axis to confer distinctively heightened proliferation and adventitial remodelling in pulmonary hypertension.
These data suggest a differential requirement of JNK1 and p38 MAPK (zeige MAPK14 Proteine) in TNF (zeige TNF Proteine) regulation of E2F1 (zeige E2F1 Proteine). Targeted inactivation of JNK1 at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (zeige TNF Proteine)-mediated EC dysfunction.
PKD (zeige PRKD1 Proteine) is a critical mediator in H2O2- but not TNF (zeige TNF Proteine)-induced ASK1 (zeige MAP3K5 Proteine)-JNK signaling
ATF3 (zeige ATF3 Proteine) induction by acute hypoxia is mediated by nitric oxide and the JNK pathway in endothelial cells
JNK plays an important role in the induction of apoptosis in transformed bovine brain endothelial cells stimulated by LPS (zeige IRF6 Proteine)
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, janus kinase 1
, mitogen-activated protein kinase 8