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Human JNK Protein expressed in Baculovirus infected Insect Cells - ABIN593493
Sury, McShane, Hernandez-Miranda, Birchmeier, Selbach et al.: Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU ... in Molecular & cellular proteomics : MCP 2015
Human JNK Protein expressed in Wheat germ - ABIN1310303
Prause, Christensen, Billestrup, Mandrup-Poulsen: JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. in PLoS ONE 2014
aken together, these results reveal that inactivation of Rpd3 (zeige HDAC1 Proteine) independently regulates JNK and Yki (zeige YAP1 Proteine) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (zeige HDAC1 Proteine) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (zeige EGFR Proteine)) pathway in the lateral epidermis for sustained dpp (zeige TGFb Proteine) expression in the LE. Specifically, we demonstrate that Egfr (zeige EGFR Proteine) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS (zeige ETS1 Proteine)-domain factor Ets21c and the nuclear receptor Ftz-F1 (zeige NR5A2 Proteine), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (zeige ROS1 Proteine)/JNK/p38 (zeige MAPK14 Proteine)/Upd (zeige UROD Proteine) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (zeige NOTCH1 Proteine)-Src (zeige SRC Proteine) synergy.
This study demonstrated that the mechanism by which Bsk (zeige FRK Proteine) is required for pruning is through reducing the membrane levels of the adhesion molecule (zeige NCAM1 Proteine) Fasciclin II (zeige NCAM2 Proteine) (FasII)
Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (zeige AMPH Proteine)-PNP (zeige NP Proteine)) and magnesium.
ERK1 (zeige MAPK3 Proteine) Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun (zeige JUN Proteine) Activity and Cell Transformation.
TGM2 (zeige TGM2 Proteine) is involved in amyloid-beta (1-42)-induced pro-inflammatory activation via AP1 (zeige FOSB Proteine)/JNK signaling pathways in cultured monocytes.
NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys (zeige LYZ Proteine) 68 residue of JNK, impairs JNK's interaction with an upstream kinase MKK7 (zeige MAP2K7 Proteine), thus disrupting JNK phosphorylation and activation.
The surface immune molecule CD274 (zeige CD274 Proteine) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (zeige CD274 Proteine)/JNK/Cyclin D2 (zeige CCND2 Proteine) pathway promotes the cell cycle entry of LIC.
These data implicate HTRA1 (zeige HTRA1 Proteine) as a negative regulator of mesenchymal stem cell adipogenesis.
Our findings indicate that GADD45 (zeige GADD45A Proteine) essentially suppresses the MKK7 (zeige MAP2K7 Proteine)-JNK pathway and suggest that differentially expressed GADD45 (zeige GADD45A Proteine) family members fine-tune stress-inducible JNK activity.
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus
post-translational modification facilitates the mobilization of SIRT6 (zeige SIRT6 Proteine) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (zeige PARP1 Proteine)) to DNA break sites and for efficient repair of double-strand break.
PRDM5 (zeige PRDM5 Proteine) promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression and strategies targeting PRDM5 (zeige PRDM5 Proteine) may be promising for the therapy of melanoma.
This study showed that the induction level of IL-32 (zeige IL32 Proteine) was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS (zeige IRF6 Proteine)-induced IL-32 (zeige IL32 Proteine) expression in nasal polyp-derived fibroblasts was regulated via the TLR4 (zeige TLR4 Proteine)/JNK/AKT (zeige AKT1 Proteine)/CREB (zeige CREB1 Proteine) signaling pathway.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
transgenic mice overexpressing sPLA2 -IIA (zeige PLA2G2A Proteine) keratinocytes showed enhanced activation of EGFR (zeige EGFR Proteine) and JNK1/2 that led to c-Jun (zeige JUN Proteine) activation.
p53 (zeige TP53 Proteine) plays a novel protective role in APAP induced liver injury through inhibiting the activation of JNK, a key mediator in APAP-induced oxidative stress.
We crossed Ptf1a (zeige PTF1A Proteine)(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a (zeige PTF1A Proteine)(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 (zeige CCL20 Proteine) secretion
BOC (zeige BOC Proteine) interacts with ABL (zeige ABL1 Proteine) and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
The authors have found that JNK signaling is required for proper vascular morphogenesis and the normal formation of collateral arteries in muscle.
JNK1-mediated NLRP3 (zeige NLRP3 Proteine) phosphorylation at S194 is a critical priming event and is essential for NLRP3 (zeige NLRP3 Proteine) inflammasome activation.
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (zeige CASP3 Proteine)-dependent Proteolysis of JNK1-2 and Bid (zeige BID Proteine).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (zeige GUSB Proteine).
Data show that the death pathway is independent of ERK (zeige MAPK1 Proteine) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (zeige CDK1 Proteine) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (zeige CA2 Proteine))+ and ROS (zeige ROS1 Proteine) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (zeige CA2 Proteine))+/CaMs and MAP kinase (zeige MAPK1 Proteine) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (zeige ROS1 Proteine) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (zeige MAPK14 Proteine) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (zeige AXIN1 Proteine)/JNK signaling and its inhibitor Aida (zeige AIDA Proteine) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (zeige MMP13 Proteine) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (zeige INS Proteine)-IGF-1 (zeige IGF1 Proteine) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) signaling pathway, which is regulated by MLK-1 (zeige MAP3K9 Proteine) MAPK (zeige MAPK1 Proteine) kinase kinase (MAPKKK), MEK-1 (zeige MAP2K1 Proteine) MAPK (zeige MAPK1 Proteine) kinase (MAPKK), and KGB-1 (zeige KCNJ3 Proteine) JNK-like MAPK (zeige MAPK1 Proteine).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8