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anti-Human JNK Antikörper:
anti-Mouse (Murine) JNK Antikörper:
anti-Rat (Rattus) JNK Antikörper:
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Cow (Bovine) Polyclonal JNK Primary Antibody für IF (p), IHC (p) - ABIN732368
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. in Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
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Human Monoclonal JNK Primary Antibody für IP, WB - ABIN967330
Adler, Fuchs, Kim, Kraft, King, Pelling, Ronai: jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. in Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996
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Human Monoclonal JNK Primary Antibody für FACS, WB - ABIN968867
Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. in The Biochemical journal 2001
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Human Monoclonal JNK Primary Antibody für FACS, WB - ABIN968866
Kyriakis, Avruch: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. in Physiological reviews 2001
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Human Monoclonal JNK Primary Antibody für ICS - ABIN1177076
Huang, Shi, Chi: Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. in Cytokine 2009
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Human Monoclonal JNK Primary Antibody für ICS - ABIN1177075
Wagner, Nebreda: Signal integration by JNK and p38 MAPK pathways in cancer development. in Nature reviews. Cancer 2009
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Caenorhabditis elegans (C. elegans) Polyclonal JNK Primary Antibody für IHC (p), IHC - ABIN151424
Oh, Mukhopadhyay, Svrzikapa, Jiang, Davis, Tissenbaum: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Polyclonal JNK Primary Antibody für IHC, IHC (p) - ABIN4327961
Gao, Wang, Zhang, Yu, Ji, Wang, Zhang, Jiang, Jin, Huang, Zhang, Li: Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. in Journal of hepatology 2016
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Human Polyclonal JNK Primary Antibody für WB - ABIN3043004
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. in Molecular medicine reports 2014
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Human Polyclonal JNK Primary Antibody für IF (p), IHC (p) - ABIN747713
Li, Qiu, Lin, He, Hua, Yuan, Liu, Wei: c-Jun N-terminal kinase is upregulated in patients with hypospadias. in Urology 2012
Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) activation was suppressed by fusion-inducing JNK signaling.
aken together, these results reveal that inactivation of Rpd3 (zeige HDAC1 Antikörper) independently regulates JNK and Yki (zeige YAP1 Antikörper) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (zeige HDAC1 Antikörper) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (zeige EGFR Antikörper)) pathway in the lateral epidermis for sustained dpp (zeige TGFb Antikörper) expression in the LE. Specifically, we demonstrate that Egfr (zeige EGFR Antikörper) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (zeige SCRIB Antikörper)) tumors requires bZIP protein Fos, the ETS (zeige ETS1 Antikörper)-domain factor Ets21c and the nuclear receptor Ftz-F1 (zeige NR5A2 Antikörper), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (zeige ROS1 Antikörper)/JNK/p38 (zeige MAPK14 Antikörper)/Upd (zeige UROD Antikörper) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (zeige NOTCH1 Antikörper)-Src (zeige SRC Antikörper) synergy.
This study demonstrated that the mechanism by which Bsk (zeige FRK Antikörper) is required for pruning is through reducing the membrane levels of the adhesion molecule (zeige NCAM1 Antikörper) Fasciclin II (zeige NCAM2 Antikörper) (FasII)
Data suggest that H2O2 regulates cell death in granulosa cells via the ROS (zeige ROS1 Antikörper)-JNK-p53 (zeige TP53 Antikörper) pathway.
High expression of JNK is associated with invasion of gastric cancer.
JNK activation and signaling in extrahepatic cholangiocarcinoma is regulated by L1CAM.JNK role in cell migration in extrahepatic cholangiocarcinoma.
Thus, the present study indicated that parkin (zeige PARK2 Antikörper) knockout inhibits neural stem cell differentiation by JNK-dependent proteasomal degradation of p21 (zeige CDKN1A Antikörper).
JNK activation contributes to glioma cell parthanatos caused by oxidative stress via increase of intracellular reactive oxygen species generation.
ERK1 (zeige MAPK3 Antikörper) Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun (zeige JUN Antikörper) Activity and Cell Transformation.
TGM2 (zeige TGM2 Antikörper) is involved in amyloid-beta (1-42)-induced pro-inflammatory activation via AP1 (zeige FOSB Antikörper)/JNK signaling pathways in cultured monocytes.
NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys (zeige LYZ Antikörper) 68 residue of JNK, impairs JNK's interaction with an upstream kinase MKK7 (zeige MAP2K7 Antikörper), thus disrupting JNK phosphorylation and activation.
The surface immune molecule CD274 (zeige CD274 Antikörper) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (zeige CD274 Antikörper)/JNK/Cyclin D2 (zeige CCND2 Antikörper) pathway promotes the cell cycle entry of LIC.
These data implicate HTRA1 (zeige HTRA1 Antikörper) as a negative regulator of mesenchymal stem cell adipogenesis.
Jnk1 deficiency inhibits the development of neural stem cells/precursors
Suppressing P38 (zeige CRK Antikörper) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
transgenic mice overexpressing sPLA2 -IIA (zeige PLA2G2A Antikörper) keratinocytes showed enhanced activation of EGFR (zeige EGFR Antikörper) and JNK1/2 that led to c-Jun (zeige JUN Antikörper) activation.
p53 (zeige TP53 Antikörper) plays a novel protective role in APAP induced liver injury through inhibiting the activation of JNK, a key mediator in APAP-induced oxidative stress.
We crossed Ptf1a (zeige PTF1A Antikörper)(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a (zeige PTF1A Antikörper)(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 (zeige CCL20 Antikörper) secretion
BOC (zeige BOC Antikörper) interacts with ABL (zeige ABL1 Antikörper) and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus
post-translational modification facilitates the mobilization of SIRT6 (zeige SIRT6 Antikörper) to DNA damage sites and is required for efficient recruitment of poly (ADP-ribose) polymerase 1 (PARP1 (zeige PARP1 Antikörper)) to DNA break sites and for efficient repair of double-strand break.
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (zeige CASP3 Antikörper)-dependent Proteolysis of JNK1-2 and Bid (zeige BID Antikörper).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (zeige GUSB Antikörper).
Data show that the death pathway is independent of ERK (zeige MAPK1 Antikörper) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (zeige CDK1 Antikörper) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (zeige CA2 Antikörper))+ and ROS (zeige ROS1 Antikörper) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (zeige CA2 Antikörper))+/CaMs and MAP kinase (zeige MAPK1 Antikörper) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (zeige ROS1 Antikörper) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (zeige MAPK14 Antikörper) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (zeige AXIN1 Antikörper)/JNK signaling and its inhibitor Aida (zeige AIDA Antikörper) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (zeige MMP13 Antikörper) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Findings indicate the MIG-15/JNK-1 pathway can restrict both glutamatergic synapse formation and short-term learning.
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (zeige INS Antikörper)-IGF-1 (zeige IGF1 Antikörper) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (zeige MAPK1 Antikörper) (MAPK (zeige MAPK1 Antikörper)) signaling pathway, which is regulated by MLK-1 (zeige MAP3K9 Antikörper) MAPK (zeige MAPK1 Antikörper) kinase kinase (MAPKKK), MEK-1 (zeige MAP2K1 Antikörper) MAPK (zeige MAPK1 Antikörper) kinase (MAPKK), and KGB-1 (zeige KCNJ3 Antikörper) JNK-like MAPK (zeige MAPK1 Antikörper).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8