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High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer.
In the cultured human lens epith (zeige TP53 Proteine)elial cells, HSF4 could stabilize and retain p53 in the nucleus to activate its target genes such as fas cell surface death receptor (Fas) and Bcl-2-associated X apo (zeige TP53 Proteine)ptosi (zeige FAS Proteine)s regula (zeige BAX Proteine)tor (Bax).
HMOX-1 (zeige HMOX1 Proteine), an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial cells). HSF4 directly binds to the HSE (zeige HSD17B6 Proteine) element in HMOX-1 (zeige HMOX1 Proteine) promoter to mediate its mRNA transcription and protein accumulation.
report on a novel homozygous HSF4 mutation (c.521T>C, p.Leu174Pro) in two sibs with congenital cataracts
BCAS2 (zeige BCAS2 Proteine) interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
HSF4 may work as a switch between lens epithelial cell proliferation and secondary fiber cell differentiation, a process which mainly depends on p53 (zeige TP53 Proteine).
Nuclear HSF2 and HSF4 bound to HSF1 (zeige HSF1 Proteine) only after heat shock.
concluded that the new mutation of c.331C>T in HSF4 DNA may be responsible for the autosomal dominant congenital cataract in this family
We found that HSF4 downregulation led to decrease of HIF1alpha (zeige HIF1A Proteine) mRNA expression
HSF4 p.Arg116His recreates the childhood lamellar cataract in mice suggesting that incomplete penetrance associated with early cataracts may not be an absence but a limitation of the detection of the phenotype
a novel molecular mechanism of HSF4 in regulating lens epithelial cell homeostasis
The deletion of Hsf4 affects the expression of many genes, such as Ubc, Ptgs2, Egr1 and Fos. These genes may be involved in the development of cataract.
A novel regulatory mechanism between Hsf1 (zeige HSF1 Proteine) and Hsf4b in modulating lens epithelial cell homeostasis.
Mutations in the DNA binding domain (DBD) of the heat shock transcription factor 4 (HSF4) are known to be associated with early childhood autosomal dominant lamellar cataract.
This comparative analysis with CRYAB (zeige CRYAB Proteine) and HSP70 (zeige HSP70 Proteine) demonstrates that differential heat shock response is controlled by cell-type-dependent access of HSF1 (zeige HSF1 Proteine) and HSF4 to specific promoters, independent of the promoter architecture.
Hsf4b is a novel downstream transcription factor of FGF2 (zeige FGF2 Proteine), and its transcription activity is associated with FGF2 (zeige FGF2 Proteine)-modulated lens epithelial cell-fiber cell transition.
These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation.
Data reveal the lens-specific role of heat shock transcription factor 4 (HSF4), and indicate that HSF1 (zeige HSF1 Proteine) and HSF4 are involved in regulating expression of growth factor genes.
HSF4 fulfills a central role in controlling spatial and temporal expression of genes critical for correct development and function of the lens.
In the hsf4(null) fish, both p53 (zeige TP53 Proteine) and activated-caspase3 were significantly decreased. Combined with the finding that the denucleation defect could be partially rescued through microinjection of p53 (zeige TP53 Proteine), fas (zeige FASN Proteine) and bax (zeige BAX Proteine) mRNA into the mutant embryos, we directly proved that HSF4 promotes lens fiber cell differentiation by activating p53 (zeige TP53 Proteine) and its downstream regulators
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.
, HSTF 4
, heat shock factor protein 4
, DNA binding protein
, binds heat shock DNA elements
, heat shock factor 4
, heat shock transcription factor 4 variant a
, heat shock transcription factor 4 variant b
, heat shock transcription factor 4 variant c