Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Oculodentodigital dysplasia is a rare genetic disorder characterized by abnormal craniofacial, dental, ocular, and digital features, is caused by mutations in the gap junction alpha-1 (GJA1) gene.
These results suggest that ROS and autophagy play an important role in regulating the Src-Cx43 axis to affect the radiation-induced bystander effects.
Cx43 distinctly regulated wound healing-related gene expression in gingival fibroblasts and skin fibroblasts.
Connexin 43-connexin 47 channels are important for astrocyte/ oligodendrocyte cross-talk in myelination and demyelination. (Review)
High GJA1 expression is associated with breast neoplasms.
Nuclear localization of Cx43-20k and N-cad expression is BTF3 dependent.
The LB2003 cells, devoid of three key K(+) uptake transport mechanisms, cannot grow in low-[K(+)] medium, but expression of Cx26, Cx43, or Cx46 rescues their growth defect (growth complementation
Novel role for Cx43-formed unidirectional gap junctional intercellular communication was in mediating metabolic coupling between cancer-associated fibroblasts and non-small cell lung cancer cells and thereby facilitating malignant progression of NSCLC by enhancing oxidative phosphorylation and increasing ATP-activated PI3K/Akt and MAPK/ERK signaling pathways.
Study demonstrated overexpression of Ubc9 protein in osteosarcoma. Silencing Ubc9 in osteosarcoma cell lines induced decoupling of SUMO1 from Cx43, generating increased free Cx43 levels, which is important for reconstructing gap junction intercellular communication and recovering cellular functions.
These results demonstrate that the Cx43 SH3-binding domain, in addition to the CT9 region, critically controls hemichannel activity at high [Ca(2+)]i, which may be involved in pathological hemichannel opening.
Pinocembrin alleviated ventricular arrhythmia in I/R rats via enhancing Na+-K+ATPase and Ca+-Mg2+ATPase activity and upregulating Cx43 and Kir2.1 protein expression.
A Tunisian family with ODDD marked by neurologic signs with anticipation which is uncommon in this disease and extends the mutational spectrum of the GJA1 gene by a novel mutation in the L2 region of Cx43.
Our understanding of these interactions is, by far, most well developed for connexin 43 (Cx43) and the scope of this review is to summarize our current knowledge of their functional and regulatory roles. The significance of these interactions is further exemplified by demonstrating their importance at the intercalated disc, a major hub for Cx43 regulation and Cx43 mediated effects
In progesterone control of myometrial contractility during pregnancy and labour, while liganded nuclear progesterone receptor B can suppress the expression of Cx43, unliganded progesterone receptor A paradoxically translocates to the nucleus where it acts as a transcriptional activator of this labour gene.
Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion.
Study found a significant difference in the expression of Cx43 and SUMO1 between cancer stem cells and non-cancer stem cells in liver cancer. By the co-expression of Cx43 and SUMO1 in cancer stem cells, the gap junction intercellular communication of liver cancer stem cells was obviously improved.
The frequency of the single nucleotide polymorphism rs2071166 was significantly higher in atrial septal defect cases than in healthy controls. The CC genotype at rs2071166 site in Cx43 was correlated with an increased risk for atrial septal defect and the C allele was positively correlated with atrial septal defect.
inhibition of Connexin43 signalling plays a more significant role in regulating cell proliferation than cell migration.
Our results suggest that keratinization in the hair follicle is closely related to the decrease in Cx43 expression
Human Cx46 V44M mutant causing cataracts result in abnormally decreased formation of gap junction plaques and impaired gap junction channel function.
Cx43 silence inhibits mechanical stress-induced apoptosis in chondrocyte, which might be mediated by JNK signaling pathway
Changes in gap junction assembly and formation in response to temporary oxygen and glucose deprivation with subsequent reoxygenation in primary murine astrocytes occur as early as six hours after initiation, pointing to an early regulatory mechanism in astrocytes. Results support the notion that gap junctional changes are part of the initial pathological cascade in astrocytes.
Mouse hepatitis virus infection can directly affect expression and cellular distribution of Cx43.
our data demonstrate that Cx43 is required for maintaining the mitochondrial integrity and metabolic activity of BAT.
Overall, our data indicate that Cx43 gap junctions in Sertoli cells influence male germ cell development and differentiation rather than their survival.
Cx43 GJs are aberrantly increased in Familial cerebral cavernous malformations type III and regulate barrier permeability by a junction structure-dependent mechanism.
the levels of mRNAs encoding Connexin43 or Connexin45 were not or were only marginally affected, respectively, by Clmp deficiency, the absence of CLMP caused a severe reduction of both proteins in smooth muscle cells of the intestine and of Connexin43 in the ureter.
Gap junction composed of Cx43 inhibits I-10/cisplatin cell invasion and migration.
specific deletion of astroglial Cx43 in APP/PS1 mice improved cognitive dysfunction by decreasing astrogliosis and increasing synaptic function without affecting amyloid plaque formation or the inflammatory response
work directly links phosphorylation of Cx43 to astrocytic coupling and apoptosis and ultimately to vascular regeneration in retinal ischemia. This study reveals that targeting Cx43 phosphorylation in astrocytes is a potential direction for the treatment of proliferative retinopathies.
Study confirmed the disruption of coupling between radial glia-like cells and astrocytes in the hippocampus of Cx43G138R mice. Proliferative activity and neurogenesis in the dentate gyrus were significantly decreased in the mutant mouse line, indicating that functional Cx43 channels are essential for proper adult neurogenesis.
Coxsackievirus B3 infection reduced Cx43 expression by elevating miR-1 level in mouse viral myocarditis.
oxytocin, PGE2, and Cx43 are increased in the uterine smooth muscle of pregnant mice with Yimu San (YMS), a Chinese veterinary medicine micro mist
our findings suggest that the role of Cx43 in response to H2O2 stress is dependent on the activation of AMPK signaling pathways and regulates ROS production and cell necrosis.
The tenotomy mice treated with Cx43 shRNA injection indicated a reduction in total heterotopic ossification (HO) volume at 4 and 8 weeks after injury.
The treatment of Salmonella enterica serovar choleraesuis or resveratrol in murine melanoma cells demonstrated the ability of reducing IDO1 production through upregulating Cx43.
At 3days after the first tamoxifen injection, Akt1(-/-)/iAkt2 KO hearts showed decreased expression of connexin43 (Cx43) and connexin-interacting protein zonula occludens-1 (ZO-1). Furthermore, Akt1/2 silencing significantly decreased both Cx43 and ZO-1 expression
we confirmed that Th1 cell-conditioned medium decreased Cx43 protein levels in mixed glial cell cultures. These findings suggest that Th1 cell-derived IFNg activates microglia to release IL-1b that reduces Cx43 gap junctions in astrocytes. Thus, Th1-dominant inflammatory states disrupt astrocytic intercellular communication and may exacerbate multiple sclerosis.
Results suggest that gap junctions are present not only among tanycytes, but also between tanycytes and the axons of hypophysiotropic neurons. Cx43 hemichannels may also facilitate the transport between tanycytes and extracellular fluids, including the cerebrospinal fluid, extracellular space of the median eminence and bloodstream.
The most aggressive trans-differentiated (phenotypically epithelial) cell strain, NIH3T3x8x3 acquired metastatic phenotypic changes accompanied ~40% reduction in endogenous or radiation-induced connexin-43 expression/mitochondrial translocation. Parental (NIH3T3) and reverting (NIH3T3x12) strains lacked hyperradiosensitivity and had distinct radiation-induced Cx43 translocation into mitochondria.
both Smp and beta-catenin function in a common molecular pathway with cx43 to influence both evx1 expression and joint location.
Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.
serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone responsible for proper folding of procollagen molecules.
Hapln1a-ECM stabilizes the secreted growth factor Semaphorin3d (Sema3d), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.
Hapln1a has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton
increased expression in Dupuytren's disease
Sema3d functions in a common molecular pathway with Cx43 cell proliferation and joint formation
Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL) exhibited osteogenic characteristics, in which Cx43 played an important role.
Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.
Data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and IGF-1-induced Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor.
These results of this study suggested that alterations of astrocyte connexins might be involved in the suicide process and provide further evidence implicating astrocytes in psychopathology.
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45.
Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.
Cx43 is crucial for TJ reassembly at the blood-testis barrier during its cyclic restructuring throughout the seminiferous epithelial cycle of spermatogenesis
Neonatal murine atrial myocytes showed similar abundances of Cx40 and Cx43 proteins, while ventricular myocytes contained at least 20 times more Cx43 than Cx40.
There was a lack of membranous distribution of connexins or a shift from moderately membranous immunoreactivity to predominantly cytoplasmic accumulation of CX32 and CX43 in studied colon tumors.
Cx48.5, Cx44.1, Cx43 have roles in lens development
The fin length mutant short fin (sof), which causes defects in the length of bony fin ray segments, is caused by mutations in the connexin43 (cx43) gene.
molecular cloning; Cx43alpha1 gap junctions are likely to have conserved roles in vertebrate embryonic development
Measurable differences in Cx43 function may be correlated with the severity of defects in bone length.
This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.
Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.
RhoA appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress
Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.
Human TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells
Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.
Expression in the rumen epithelium.
intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26, Cx32, and Cx43
CBN blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.
Results describe the effect of suppression of connexin 43 and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
These findings indicated that Cx43/miR-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.
Vascular remodeling post stent implantation varied according to the presence of balloon injury, cholesterol-enriched diet, or both.
Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.
Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.
In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart
The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.
CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.
Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.
The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.
we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.
The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.
Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.
Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.
These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.
Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.
Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.
During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.
These results indicate that changes of Cx43 expression in the porcine myometrium during the oestrous cycle may be regulated by progesterone concentration and may contribute to the modulation of uterine motility.
We conclude, therefore, that two major components of cell-cell interaction synergistically regulate cell cycle progression in HEK293 cells by regulating p21 expression in a beta-catenin/TCF-dependent manner.
Limiting Cx43 expression in vascular smooth muscle cells prevents platelet-derived growth factor-BB-induced phenotypic modulation.
It changes in gonad morphology and in the expression of Cx43 at the level of protein of prepubertal boars and gilts, it seems that flutamide through blocking androgen action, may be involved in the regulation of Cx43 gene expression in pig gonads.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
, gap junction 43 kDa heart protein
, gap junction alpha-1 protein
, gap junction membrane channel protein alpha 1
, alpha 1 connexin
, gap junction protein, alpha 1
, short fin protein
, gap junction protein, alpha 1, 43 kD (connexin 43)
, vascular smooth muscle connexin-43
, alpha 1 gap junction protein
, gap junction protein, alpha 1, 43kDa (connexin 43)
, gap junction protein alpha 1