Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
A Tunisian family with ODDD marked by neurologic signs with anticipation which is uncommon in this disease and extends the mutational spectrum of the GJA1 gene by a novel mutation in the L2 region of Cx43.
Our understanding of these interactions is, by far, most well developed for connexin 43 (Cx43) and the scope of this review is to summarize our current knowledge of their functional and regulatory roles. The significance of these interactions is further exemplified by demonstrating their importance at the intercalated disc, a major hub for Cx43 regulation and Cx43 mediated effects
In progesterone control of myometrial contractility during pregnancy and labour, while liganded nuclear progesterone receptor (zeige PGR Proteine) B can suppress the expression of Cx43, unliganded progesterone receptor (zeige PGR Proteine) A paradoxically translocates to the nucleus where it acts as a transcriptional activator of this labour gene.
Ezrin (zeige EZR Proteine)-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion.
Study found a significant difference in the expression of Cx43 and SUMO1 (zeige SUMO1 Proteine) between cancer stem cells and non-cancer stem cells in liver cancer. By the co-expression of Cx43 and SUMO1 (zeige SUMO1 Proteine) in cancer stem cells, the gap junction intercellular communication of liver cancer stem cells was obviously improved.
The frequency of the single nucleotide polymorphism rs2071166 was significantly higher in atrial septal defect cases than in healthy controls. The CC genotype at rs2071166 site in Cx43 was correlated with an increased risk for atrial septal defect and the C allele was positively correlated with atrial septal defect.
inhibition of Connexin43 signalling plays a more significant role in regulating cell proliferation than cell migration.
Our results suggest that keratinization in the hair follicle is closely related to the decrease in Cx43 expression
Human Cx46 (zeige GJA3 Proteine) V44M mutant causing cataracts result in abnormally decreased formation of gap junction plaques and impaired gap junction channel function.
Abnormal expression of Cx43 in the cerebral arteries may play an important role in the formation of vascular intima thickening in patients with moyamoya disease.
the levels of mRNAs encoding Connexin43 or Connexin45 were not or were only marginally affected, respectively, by Clmp (zeige CLMP Proteine) deficiency, the absence of CLMP (zeige CLMP Proteine) caused a severe reduction of both proteins in smooth muscle cells of the intestine and of Connexin43 in the ureter.
Gap junction composed of Cx43 inhibits I-10/cisplatin cell invasion and migration.
specific deletion of astroglial Cx43 in APP (zeige APP Proteine)/PS1 (zeige PSEN1 Proteine) mice improved cognitive dysfunction by decreasing astrogliosis and increasing synaptic function without affecting amyloid plaque formation or the inflammatory response
work directly links phosphorylation of Cx43 to astrocytic coupling and apoptosis and ultimately to vascular regeneration in retinal ischemia. This study reveals that targeting Cx43 phosphorylation in astrocytes is a potential direction for the treatment of proliferative retinopathies.
Study confirmed the disruption of coupling between radial glia-like cells and astrocytes in the hippocampus of Cx43G138R mice. Proliferative activity and neurogenesis in the dentate gyrus were significantly decreased in the mutant mouse line, indicating that functional Cx43 channels are essential for proper adult neurogenesis.
Coxsackievirus B3 infection reduced Cx43 expression by elevating miR-1 level in mouse viral myocarditis.
oxytocin, PGE2, and Cx43 are increased in the uterine smooth muscle of pregnant mice with Yimu San (YMS), a Chinese veterinary medicine micro mist (zeige CLNK Proteine)
our findings suggest that the role of Cx43 in response to H2O2 stress is dependent on the activation of AMPK (zeige PRKAA1 Proteine) signaling pathways and regulates ROS (zeige ROS1 Proteine) production and cell necrosis.
The tenotomy mice treated with Cx43 shRNA injection indicated a reduction in total heterotopic ossification (HO) volume at 4 and 8 weeks after injury.
The treatment of Salmonella enterica serovar choleraesuis or resveratrol in murine melanoma cells demonstrated the ability of reducing IDO1 (zeige IDO1 Proteine) production through upregulating Cx43.
Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal.
serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone (zeige HSP90AA1 Proteine) responsible for proper folding of procollagen molecules.
Hapln1a (zeige HAPLN1 Proteine)-ECM (zeige MMRN1 Proteine) stabilizes the secreted growth factor (zeige WNT2 Proteine) Semaphorin3d (Sema3d (zeige SEMA3D Proteine)), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration.
Hapln1a (zeige HAPLN1 Proteine) has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton
Sema3d (zeige SEMA3D Proteine) functions in a common molecular pathway with Cx43 cell proliferation and joint formation
Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL (zeige COL6A1 Proteine)) exhibited osteogenic characteristics, in which Cx43 played an important role.
Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role.
Data demonstrate a cross-talk between IGF-1R (zeige IGF1R Proteine) and AT-1R in AT-II and IGF-1 (zeige IGF1 Proteine)-induced Cx43 expression in SV SMCs involving Erk 1 (zeige MAPK3 Proteine)/2 and downstream activation of the AP-1 (zeige JUN Proteine) transcription factor.
Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45 (zeige GJC1 Proteine).
Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis.
This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis.
Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration.
RhoA (zeige RHOA Proteine) appears to be an important molecular switch that controls Cx43 hemichannel openings and hemichannel-mediated ATP-dependent paracrine intercellular communication under (patho)physiological conditions of stress
Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.
Human TGF-beta1 (zeige TGFB1 Proteine) induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells
Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction.
intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26 (zeige GJB2 Proteine), Cx32 (zeige GJB1 Proteine), and Cx43
CBN (zeige CALB1 Proteine) blocks junctional communication and modulates Cx43 expression in BAEC. These results suggest a feedback mechanism for control of connexin expression based on junctional patency.
Results describe the effect of suppression of connexin 43 and E-cadherin (zeige CDH1 Proteine) on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
These findings indicated that Cx43/miR (zeige MYLIP Proteine)-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.
Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.
Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.
In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart
The localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding spiral ganglion cell bodies in man and guinea pig, were analyzed.
CX43 is therefore essential for the maintenance of spontaneous slow wave activity and subsequent contractile activity in the guinea pig prostate gland.
Data show that connexin 43 (Cx43) is localized in the ooplasmic membrane through zona pellucidae and its level changes over time during culture in porcine oocytes.
The effects of flutamide on connexin 43 expression in porcine placenta and uterus throughout pregnancy are reported.
we demonstrated that modulation of Cx43 expression in the prostate could serve as a sensitive marker of hormonal disruption during different developmental stages.
The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 and Cdk4 (zeige CDK4 Proteine) gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.
Gonadotropins regulate Cx43 protein expression, degradation and localization in porcine cumulus oocyte complex.
Gene transfer-mediated overexpression of Cx43 increases the absolute amount of phosphorylated and intercalated disk-localized Cx43, improves conduction velocity (CV), and reduces ventricular tachycardia inducibility.
These data suggest that neonatal exposure to flutamide induces long-term effects on the spermatogenic capacity of the pig testis through alterations of Cx43-mediated intercellular communication.
Cx43 expression and distribution are disrupted by ischemia, recovered by the well reperfused regions and further disrupted by no-reflow.
Atrial connexin 43 was reduced in atrial fibrillation. Connexin 43 gene therapy prevented persistent atrial fibrillation.
During ventricular fibrillation, myocardial Cx43 expression was down-regulated, which could be attenuated by administration of ZP123.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations.
, gap junction 43 kDa heart protein
, gap junction alpha-1 protein
, gap junction membrane channel protein alpha 1
, alpha 1 connexin
, gap junction protein, alpha 1
, short fin protein
, gap junction protein, alpha 1, 43 kD (connexin 43)
, vascular smooth muscle connexin-43
, alpha 1 gap junction protein
, gap junction protein, alpha 1, 43kDa (connexin 43)
, gap junction protein alpha 1