anti-Human GJA1 Antikörper für Immunohistochemistry (Formalin-fixed Sections)

Recommended GJA1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Gap Junction Protein, alpha 1, 43kDa (GJA1) Antikörper
  • AVSD3
  • CX43
  • DFNB38
  • GJAL
  • HLHS1
  • HSS
  • ODDD
  • Cx43
  • AU042049
  • AW546267
  • Cnx43
  • Cx43alpha1
  • Gja-1
  • Npm1
  • connexin43
  • cx43a1
  • gja1
  • zfCx43.3
  • connexin 43
  • gja1-A
  • cx43
  • gjal
  • oddd
  • dfnb38
  • gap junction protein alpha 1
  • gap junction protein, alpha 1
  • connexin 43
  • gap junction protein alpha 1 L homeolog
  • CONNEXIN 43 protein
  • GJA1
  • Gja1
  • cx43
  • gja1.L
  • gja1
  • CONNEXIN 43
Epitop
AA 252-270
70
21
18
17
15
14
12
10
8
6
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Huhn, Hund, Human, Maus, Ratte (Rattus)
281
196
180
53
23
22
22
17
16
15
12
10
9
7
6
6
5
3
3
3
3
3
2
1
1
1
1
Wirt
Maus
277
34
23
1
Klonalität
Monoklonal
Konjugat
Dieser GJA1 Antikörper ist unkonjugiert
6
5
5
4
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
Applikation
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
262
153
109
76
45
24
22
19
19
14
7
4
2
1
1
Optionen
Hersteller
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Produktnummer ABIN967718
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN967717 IHC (f) IF IP WB Mouse IgG1 AA 252-270 Anmelden zum Anzeigen 2-Connexin 5

General

Antigen Gap Junction Protein, alpha 1, 43kDa (GJA1) Antikörper
Epitop AA 252-270
(70), (21), (18), (17), (15), (14), (12), (10), (8), (6), (5), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Huhn, Hund, Human, Maus, Ratte (Rattus)
(281), (196), (180), (53), (23), (22), (22), (17), (16), (15), (12), (10), (9), (7), (6), (6), (5), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1)
Wirt Maus
(277), (34), (23), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser GJA1 Antikörper ist unkonjugiert
(6), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applikation Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(262), (153), (109), (76), (45), (24), (22), (19), (19), (14), (7), (4), (2), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-GJA1 Antikörper

Target Details GJA1 Anwendungsinformationen Handhabung Referenzen für anti-GJA1 Antikörper (ABIN967718) Bilder
Kreuzreaktivität Huhn, Hund, Human, Maus
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Rat Connexin-43 aa. 252-270
Klon 2-Connexin
Isotyp IgG1

Target Details GJA1

Produktdetails anti-GJA1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-GJA1 Antikörper (ABIN967718) Bilder zurück nach oben
Antigen
Andere Bezeichnung Connexin-43 (GJA1 Antibody Abstract)
Hintergrund Gap junctions are intercellular protein pores. They enable cell-to-cell communication by allowing passage of ions and other small molecules. The subunits of gap junction channels are assembled from a family of proteins called connexins. Individual connexin molecules join to make hexameric hemichannels termed connexons, these structures dock to connexons on neighboring cells, forming gap junction pores. Connexin-43 is a member of the connexin family possessing four transmembrane regions, with cytoplasmic amino and carboxyl terminals. It undergoes rapid turnover in the cell and its monomers may reside in the ER/Golgi network, forming a reservoir available for assembly upon degradation of existing connexin-43 channels. In addition, it is believed that phosphorylation of connexin-43 plays a regulatory role both in the assembly of connexons and in gating activity at the gap junction. This antibody is routinely tested by western blot analysis.
Molekulargewicht 43 kDa
Pathways MAPK Signalweg, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization

Anwendungsinformationen

Produktdetails anti-GJA1 Antikörper Target Details GJA1 Handhabung Referenzen für anti-GJA1 Antikörper (ABIN967718) Bilder zurück nach oben
Kommentare

Related Products: ABIN968545, ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-GJA1 Antikörper Target Details GJA1 Anwendungsinformationen Referenzen für anti-GJA1 Antikörper (ABIN967718) Bilder zurück nach oben
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20° C.

Referenzen für anti-GJA1 Antikörper (ABIN967718)

Produktdetails anti-GJA1 Antikörper Target Details GJA1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Giepmans, Hengeveld, Postma, Moolenaar: "Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 8544-9, 2001

Toyofuku, Akamatsu, Zhang, Kuzuya, Tada, Hori: "c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes." in: The Journal of biological chemistry, Vol. 276, Issue 3, pp. 1780-8, 2001

Lucke, Choudhry, Thom, Selmer, Burden, Hodgins: "Upregulation of connexin 26 is a feature of keratinocyte differentiation in hyperproliferative epidermis, vaginal epithelium, and buccal epithelium." in: The Journal of investigative dermatology, Vol. 112, Issue 3, pp. 354-61, 1999

Laird, Castillo, Kasprzak: "Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells." in: The Journal of cell biology, Vol. 131, Issue 5, pp. 1193-203, 1996

Loo, Berestecky, Kanemitsu, Lau: "pp60src-mediated phosphorylation of connexin 43, a gap junction protein." in: The Journal of biological chemistry, Vol. 270, Issue 21, pp. 12751-61, 1995

Bilder

Produktdetails anti-GJA1 Antikörper Target Details GJA1 Anwendungsinformationen Handhabung Referenzen für anti-GJA1 Antikörper (ABIN967718) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Gap Junction Protein, alpha 1, 43kDa (GJA1) (AA 252-270) antibody (ABIN967718) Western blot analysis of Connexin-43 on a rat cerebrum lysate. Lane 1: 1:250, lane 2:...
Immunofluorescence (IF) image for anti-Gap Junction Protein, alpha 1, 43kDa (GJA1) (AA 252-270) antibody (ABIN967718) Immunofluorescence staining on WI38 cells (human lung).
 image for anti-Gap Junction Protein, alpha 1, 43kDa (GJA1) (AA 252-270) antibody (ABIN967718) anti-Gap Junction Protein, alpha 1, 43kDa (GJA1) (AA 252-270) antibody (Image 3)