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Human ERK2 Protein expressed in Wheat germ - ABIN1310256
Abeydeera, Egli, Cox, Mercier, Conde, Pallan, Mizurini, Sierant, Hibti, Hassell, Wang, Liu, Liu, Martinez, Sood, Lybrand, Frydman, Monteiro, Gomer, Nawrot, Yang: Evoking picomolar binding in RNA by a single phosphorodithioate linkage. in Nucleic acids research 2016
Human ERK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001936
Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001
Show all 2 Pubmed References
results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARalpha (zeige PPARA Proteine) signaling, inhibiting the TLR4 (zeige TLR4 Proteine)-mediated NF-kappaB (zeige NFKB1 Proteine) signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4 (zeige TLR4 Proteine)/ERK1/2/AP-1 (zeige FOSB Proteine)/STAT3 (zeige STAT3 Proteine)), which suggests that OEA may be a therapeutic agent for inflammatory diseases.
findings demonstrate that post-transcriptional regulation via p38 MAPK (zeige MAPK14 Proteine) plays a central role in the rapid synthesis of pro-IL-1beta (zeige IL1B Proteine) in response to MSU (zeige BCKDHA Proteine) crystals, which is an essential step for IL-1beta (zeige IL1B Proteine) production in human monocytes.
In rheumatoid arthritis (RA), the expression of TREM-2 (zeige TREM2 Proteine) was reduced at first and then up-regulated after stimulation by TNF-alpha (zeige TNF Proteine). TREM-2 (zeige TREM2 Proteine) also inhibited the activation of TNF-alpha (zeige TNF Proteine) induced of inflammation in RA-fibroblast-like synovial cells (FLSs) by the p38 (zeige CRK Proteine) pathway.
ITGA6 (zeige ITGA6 Proteine) might be involved in a mechanism that underlies radiation resistance and that ITGA6 (zeige ITGA6 Proteine) could be a potential target for therapies aimed at overcoming radiation resistance in breast cancer.
the physiological role of the negative crosstalk between the cAMP/PKA/AKAP4 and the PKC/ERK1/2 pathways is to regulate capacitation and acrosome reaction.
EGF (zeige EGF Proteine)-mediated lysosome trafficking, protease secretion, and invasion is regulated by the activity of p38 mitogen activated protein kinase (zeige MAPK14 Proteine) (MAPK) and sodium hydrogen exchangers (NHEs). Interestingly, EGF (zeige EGF Proteine) stimulates anterograde lysosome trafficking through a different mechanism than previously reported for HGF (zeige HGF Proteine), suggesting that there are redundant signaling pathways that control lysosome positioning
co-treatment with curcumin and cisplatin synergistically induces apoptosis through ROS-mediated activation of ERK1/2 in bladder cancer
epinephrine inhibits the Na+/K+-ATPase (zeige ATP1A1 Proteine) by the sequential activation of alpha2 adrenergic receptors, Src (zeige SRC Proteine), p38MAPK (zeige MAPK14 Proteine), and ERK (zeige EPHB2 Proteine) leading to PGE2 release.
This study thus characterizes ERK (zeige EPHB2 Proteine)-mediated suppression of TXNIP (zeige TXNIP Proteine) as a presently unreported mechanism by which ap junctions regulate cell behaviors.
Advanced glycation end products decrease collagen I levels in fibroblasts from the vaginal wall of patients with pelvic organ prolapse via the RAGE (zeige AGER Proteine), MAPK and NF-kappaB (zeige NFKB1 Proteine) pathways.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (zeige CRK Proteine) Pathways and the Interaction with Cell-Surface-HSP70 (zeige HSP70 Proteine)
persistent distention/stretch on colonic smooth muscle cells could suppress SCF (zeige KITLG Proteine) production probably through Ca(2 (zeige CA2 Proteine)+) -ERK (zeige EPHB2 Proteine)-AP-1 (zeige JUN Proteine)-miR (zeige MLXIP Proteine)-34c deregulation.
This indicates that TcpC may promote MIP2 (zeige CXCL2 Proteine) production in kidney cells through the p38 MAPK (zeige MAPK14 Proteine) signaling pathway. Taken together, the data of the present study demonstrated that TcpC can induce MIP2 (zeige CXCL2 Proteine) production, which may contribute to the characteristic histological change associated with pyelonephritis.
the hippocampal MAPK oscillation and theta rhythmic oscillations in Nf1 (zeige NF1 Proteine) (+/-) mice were disturbed and hinted about a possible mechanism for the brain dysfunction in Nf1 (zeige NF1 Proteine) (+/-) mice.
Stress-specific p38 MAPK (zeige MAPK14 Proteine) activation is sufficient to drive EGFR (zeige EGFR Proteine) endocytosis but not its nuclear translocation
This indicated that RANK might be the binding target of baicalin. In sum, our findings revealed baicalin increased osteoclast maturation and function via p-ERK (zeige EPHB2 Proteine)/Mitf (zeige MITF Proteine) signalling. In addition, the results suggest that baicalin can potentially be used as a natural product for the treatment of bone fracture
ERK2 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
Suppressing P38 (zeige CRK Proteine) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (zeige MAPK8 Proteine) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
Betacellulin (zeige BTC Proteine) promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1 (zeige MAPK3 Proteine)/Erk2.
A stimulation induced PARP1 (zeige PARP1 Proteine) binding to phosphorylated Erk2 in the chromatin of cerebral neurons caused Erk (zeige EPHB2 Proteine)-induced PARP1 (zeige PARP1 Proteine) activation, rendering transcription factors and promoters of immediate early (zeige JUN Proteine) genes (IEG) accessible to PARP1 (zeige PARP1 Proteine)-bound phosphorylated Erk2.
The present results suggest that demecolcine might contribute to the activation of the Mos (zeige MOCOS Proteine)/MAPK pathway and affect spindle structure
MAPK1 upregulated milk protein (zeige CSN2 Proteine) synthesis through the Stat5 (zeige STAT5A Proteine) and mTOR (zeige FRAP1 Proteine) pathways.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Cyclin-dependent kinase (zeige CDK1 Proteine) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (zeige MSLN Proteine)) and MAPK, and had nearly no effect on kinase activities during maturation.
Thrombospondin 1 (zeige THBS1 Proteine), fibronectin (zeige FN1 Proteine), and vitronectin (zeige VTN Proteine) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Proteine) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (zeige EGR1 Proteine) nuclear accumulation.
Role of CaMKII (zeige CAMK2G Proteine) in hydrogen peroxide activation of p38 MAPK (zeige MAPK14 Proteine)/heat shock protein 27 pathway and ERK1/2
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
Excess PLAC8 promotes an unconventional ERK2-dependent EMT (zeige ITK Proteine) in colon cancer.
ERK1/2-Akt1 (zeige AKT1 Proteine) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (zeige SH3GL1 Proteine) plays an important role in the development of the myeloid cell through activation of the ERK1 (zeige MAPK3 Proteine)/ERK2 pathway
ERK1 (zeige MAPK3 Proteine) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
These results demonstrate that induction of Hsp70 (zeige HSPA1A Proteine) in response to heat stress is dependent on ERK activation in Pac2 (zeige PSMG2 Proteine) cells.
Data define distinct roles for ERK1 (zeige MAPK3 Proteine) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
The reciprocal feedback observed between MPF (zeige MSLN Proteine) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
The data suggest a MKK3 * MPK1 * RBK1 phosphorylation cascade that may provide a dynamic module for altering cell expansion.
MKP1 (zeige DUSP1 Proteine) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.
MKP1 (zeige DUSP1 Proteine) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (zeige MAPK3 Proteine)- and MPK6 (zeige MAPK6 Proteine)-dependent manner.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Agonist stimulation of vascular smooth muscle increases PKC (zeige FYN Proteine) activity, which, in turn, increases MKP-1 (zeige DUSP1 Proteine) activity and maintains MAPK1 activity at submaximal values.
sub-vasomotor concentration of ET-1 (zeige EDN1 Proteine) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (zeige MAPK14 Proteine) kinase-mediated production of superoxide from NADPH oxidase (zeige NOX1 Proteine) following ETA receptor activation
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (zeige CSF2 Proteine) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (zeige FRAP1 Proteine) signal transduction cascades.
PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (zeige PPARG Proteine) phosphorylation.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (zeige MAPK8 Proteine)/2 dependent.
The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
, MAP kinase 1
, MAP kinase 2
, MAP kinase isoform p42
, MAPK 2
, extracellular signal-regulated kinase 2
, mitogen-activated protein kinase 2
, protein tyrosine kinase ERK2
, MAPK 1
, mitogen activated protein kinase 1
, extracellular-signal-regulated kinase 2
, mitogen-activated protein kinase 1
, MAP kinase
, mitogen-activated protein kinase 1b
, myelin basic protein kinase-like protein
, mitogen-activated protein kinase 1a
, extracellular signal-regulated kinase-2
, extracellular regulated protein 2