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Human ERK2 Protein expressed in Wheat germ - ABIN1310256
Abeydeera, Egli, Cox, Mercier, Conde, Pallan, Mizurini, Sierant, Hibti, Hassell, Wang, Liu, Liu, Martinez, Sood, Lybrand, Frydman, Monteiro, Gomer, Nawrot, Yang: Evoking picomolar binding in RNA by a single phosphorodithioate linkage. in Nucleic acids research 2016
Human ERK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001936
Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. in The Journal of biological chemistry 2001
Show all 2 Pubmed References
thrombin (zeige F2 Proteine) binding to PAR-1 (zeige MARK2 Proteine) receptor activated Gi-protein/c (zeige PROC Proteine)-Src (zeige SRC Proteine)/Pyk2 (zeige PTK2B Proteine)/EGFR (zeige EGFR Proteine)/PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/p42/p44 (zeige PSMC6 Proteine) MAPK (zeige MAPK3 Proteine) cascade, which in turn elicited AP-1 (zeige FOSB Proteine) activation and ultimately evoked MMP-9 (zeige MMP9 Proteine) expression and cell migration in SK-N-SH cells.
These results indicate that not H1 but M3 receptor-induced activation of p38 MAPK (zeige MAPK14 Proteine) might contribute to the maintenance of epithelial barrier function through down-regulation of TNF-alpha (zeige TNF Proteine) signalling and activation of EGFR (zeige EGFR Proteine).
Our findings suggest that p-MAPK1 (zeige MAPK3 Proteine) expression could identify a poor prognostic subgroup of AITL patients who could benefit from RAS/RAF (zeige RAF1 Proteine)/MEK (zeige MAP2K1 Proteine)/MAPK1 (zeige MAPK3 Proteine) pathway inhibitors or from other specific chemotherapeutic regimens.
reactivation of ERK (zeige EPHB2 Proteine) and Akt (zeige AKT1 Proteine) associated respectively with the activity of mutant BRAF (zeige BRAF Proteine) and CDC37 (zeige CDC37 Proteine) renders mutant BRAF (zeige BRAF Proteine) colon cancer cells resistant to AUY922
Is p38 MAPK (zeige MAPK14 Proteine) a Dark Force in Right Ventricular Hypertrophy and Failure in Pulmonary Arterial Hypertension.
Nestin (zeige NES Proteine) promotesneural progenitor cells (NPCs) proliferation via p38-MAPK (zeige MAPK14 Proteine) and EGFR (zeige EGFR Proteine) pathways, and reveals the necessity of these pathways in NPCs self-renewal.
Taken together, we suggest that AGEs directly promote primary breast cancer cells via the ERK (zeige EPHB2 Proteine) and NF-kappaB (zeige NFKB1 Proteine) pathway, which may lead to advanced therapeutic modalities of breast cancer.
Fas-FasL is the preferred death pathway for both Th1 and Th17 and that inherently low Erk2 activity protected Th17 cells from TCR AICD.
This study supports a role of the MAPK1 (zeige MAPK3 Proteine) gene in the biological networks related to Bipolar Disorder.
Apocynin may act as a novel molecular candidate to protect against vascular smooth muscle cell osteogenic switching/vascular calcification through suppressing ERK1/2 pathway.
Betacellulin (zeige BTC Proteine) promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1 (zeige MAPK3 Proteine)/Erk2.
A stimulation induced PARP1 (zeige PARP1 Proteine) binding to phosphorylated Erk2 in the chromatin of cerebral neurons caused Erk (zeige EPHB2 Proteine)-induced PARP1 (zeige PARP1 Proteine) activation, rendering transcription factors and promoters of immediate early (zeige JUN Proteine) genes (IEG) accessible to PARP1 (zeige PARP1 Proteine)-bound phosphorylated Erk2.
Collectively, this study firstly demonstrated that PRMT1 (zeige PRMT1 Proteine) exert podocyte-injury effects in mouse glomerulus through Ang (zeige ANG Proteine) /ERK (zeige EPHB2 Proteine) pathway, which reveals a potential therapeutic target for DN.
North American ginseng inhibits myocardial NOX2 (zeige CYBB Proteine)-ERK1/2-TNF-alpha (zeige TNF Proteine) signaling pathway and improves cardiac function in endotoxemia, suggesting that NA ginseng may have the potential in the prevention of clinical sepsis.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (zeige GFAP Proteine)-positive astrocytes for normal neurodevelopment.
These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.
these findings suggest an important role of GPR160 (zeige GPR160 Proteine) in regulating the entry of BCG (zeige SLC11A1 Proteine) into macrophages by targeting the ERK (zeige EPHB2 Proteine) signaling pathway.
Cortical neuron-specific deletion of extracellular signal-regulated kinases Erk1 (zeige MAPK3 Proteine) or Erk2 significantly increased the duration of wakefulness.
pERK1/2 is a regulator of CD44 (zeige CD44 Proteine) expression, and increased CD44 (zeige CD44 Proteine) expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
mmLDL increased the serum concentrations and expression of ICAM-1 (zeige ICAM1 Proteine) and VCAM-1 (zeige VCAM1 Proteine) by activating the ERK1/2 pathway, resulting in the expression of ETB (zeige EDNRB Proteine) receptors and the enhancement of contractile function in vascular smooth muscle.
The present results suggest that demecolcine might contribute to the activation of the Mos (zeige MOCOS Proteine)/MAPK pathway and affect spindle structure
MAPK1 upregulated milk protein (zeige CSN2 Proteine) synthesis through the Stat5 (zeige STAT5A Proteine) and mTOR (zeige FRAP1 Proteine) pathways.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Cyclin-dependent kinase (zeige CDK1 Proteine) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (zeige MSLN Proteine)) and MAPK, and had nearly no effect on kinase activities during maturation.
Thrombospondin 1 (zeige THBS1 Proteine), fibronectin (zeige FN1 Proteine), and vitronectin (zeige VTN Proteine) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Proteine) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (zeige EGR1 Proteine) nuclear accumulation.
Role of CaMKII (zeige CAMK2G Proteine) in hydrogen peroxide activation of p38 MAPK (zeige MAPK14 Proteine)/heat shock protein 27 pathway and ERK1/2
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
Excess PLAC8 promotes an unconventional ERK2-dependent EMT (zeige ITK Proteine) in colon cancer.
ERK1/2-Akt1 (zeige AKT1 Proteine) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (zeige SH3GL1 Proteine) plays an important role in the development of the myeloid cell through activation of the ERK1 (zeige MAPK3 Proteine)/ERK2 pathway
ERK1 (zeige MAPK3 Proteine) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
These results demonstrate that induction of Hsp70 (zeige HSPA1A Proteine) in response to heat stress is dependent on ERK activation in Pac2 (zeige PSMG2 Proteine) cells.
Data define distinct roles for ERK1 (zeige MAPK3 Proteine) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
The reciprocal feedback observed between MPF (zeige MSLN Proteine) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
MKP1 (zeige DUSP1 Proteine) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.
MKP1 (zeige DUSP1 Proteine) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (zeige MAPK3 Proteine)- and MPK6 (zeige MAPK6 Proteine)-dependent manner.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Agonist stimulation of vascular smooth muscle increases PKC (zeige FYN Proteine) activity, which, in turn, increases MKP-1 (zeige DUSP1 Proteine) activity and maintains MAPK1 activity at submaximal values.
sub-vasomotor concentration of ET-1 (zeige EDN1 Proteine) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (zeige MAPK14 Proteine) kinase-mediated production of superoxide from NADPH oxidase (zeige NOX1 Proteine) following ETA receptor activation
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (zeige CSF2 Proteine) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (zeige FRAP1 Proteine) signal transduction cascades.
PGRN (zeige GRN Proteine) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (zeige PPARG Proteine) phosphorylation.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (zeige MAPK8 Proteine)/2 dependent.
The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
, MAP kinase 1
, MAP kinase 2
, MAP kinase isoform p42
, MAPK 2
, extracellular signal-regulated kinase 2
, mitogen-activated protein kinase 2
, protein tyrosine kinase ERK2
, MAPK 1
, mitogen activated protein kinase 1
, extracellular-signal-regulated kinase 2
, mitogen-activated protein kinase 1
, MAP kinase
, mitogen-activated protein kinase 1b
, myelin basic protein kinase-like protein
, mitogen-activated protein kinase 1a
, extracellular signal-regulated kinase-2
, extracellular regulated protein 2