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loss of XIAP enhances filopodia formation in a Cdc42-dependent manner and this phenomenon phenocopies EGF stimulation. Further, XIAP depletion promotes lung colonization of tumor cells in mice in a Cdc42-dependent manner. These observations shed molecular insights into ubiquitin-dependent regulation of Cdc42 and that of actin cytoskeleton.
Cdc42 can affect multiple morphogenetic processes during angiogenic sprouting and ultimately impact the architecture of the vasculature.
Study identified different phenotypic correlations of nuclear versus cytoplasmic expression of CDC42, with high nuclear expression correlating with better prognostic features. These results show that CDC42 seems to be a key determinant of low-grade ER-positive breast cancers with prognostic significance. Subcellular localization may be important in determining breast cancer morphology.
Downregulation of PLEKHA7 in PACG may affect BAB (zeige RERE Proteine) integrity and aqueous humor outflow via its Rac1/Cdc42 GAP activity, thereby contributing to disease etiology.
CDC42 has an active oncogenic role in CRC (zeige CALR Proteine) via the transcriptional regulation of multiple cancer-related pathways and that CDC42-mediated silencing of CACNA2D2 (zeige CACNA2D2 Proteine) is clinically relevant.
MBQ-167 is 10x more potent than other currently available Rac (zeige AKT1 Proteine)/Cdc42 inhibitors and has the potential to be developed as an anticancer drug, as well as a dual inhibitory probe for the study of Rac (zeige AKT1 Proteine) and Cdc42
Filamin C (zeige FLNC Proteine) promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rac1/cdc42 activites in esophageal squamous cell carcinoma.
Cdc42 inhibition is required for Mig-6 (zeige ERRFI1 Proteine) suppression of cell migration induced by EGF (zeige EGF Proteine)
this study shows that miR (zeige MLXIP Proteine)-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42
activated Cdc42 is a critical determinant of the migratory and invasive phenotype of malignant gliomas; this effect may be mediated, at least in part, through its interaction with IQGAP1 and phosphorylated FAK (zeige PTK2 Proteine)
Simulated microgravity activates Cdc42 via Rap1GDS1 (zeige RAP1GDS1 Proteine) to promote vascular branch morphogenesis.
In contrast to neuronal cells, Botulinum neurotoxin type B uses a Cdc42-dependent pathway to enter intestinal cells.
We conclude that CRN7 spatiotemporally influences F-actin organization and Golgi integrity in a Cdc42- and N-WASP-dependent manner.
the expression of CDC42 might be regulated by AHR (zeige AHR Proteine), and both proteins are fundamental to the development of normal spermatozoa and the acrosome reaction.
CDC42 loss suppresses acute myeloid leukemia (zeige BCL11A Proteine) cell polarity and division asymmetry.
CDC42 is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
LRCH1 (zeige LRCH1 Proteine) as a novel effector to restrain PKCalpha (zeige PKCa Proteine)-DOCK8-Cdc42 module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE).
analysis of phenotypes of Cdc42 and Myo10 deletion that show multiple roles of filopodial dynamics
Finally, we demonstrate that Cdc42 is involved in neuroligin-dependent presynaptic differentiation of proprioceptive sensory neurons in vitro These data suggest that Cdc42 in presynaptic sensory neurons is essential for proper synapse formation in the development of monosynaptic sensory-motor circuits.
found that DOCK8 associated with LRAP35a, an adaptor molecule that binds to the Cdc42 effector myotonic dystrophy kinase-related Cdc42-binding kinase, and facilitated its activity to phosphorylate myosin II regulatory light chain
shear-stimulated integrin dynamics induce polarized Cdc42 activity, which induces MTOC localization through the Par6-protein kinase Czeta complex.
This study revealed a novel signaling pathway activated during M. avium subsp. paratuberculosis entry that links the product of MAP3464 gene to activation of Cdc42 in the host cell.
These data are consistent with the idea that migrating corneal epithelial cells use a cdc42/rho "switch" to sort vectoral cues, with cdc42 controlling electrotaxis and rho controlling contact guidance.
Knockdown of fat1 in zebrafish causes pronephric cysts, which is partially rescued by RAC1/CDC42 activators, confirming a role of the two small GTPases in the pathogenesis.
Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
Cdc42 GTPase (zeige RACGAP1 Proteine) and Rac1 GTPase (zeige RACGAP1 Proteine) act downstream of p120 catenin (zeige CTNND1 Proteine) and require GTP (zeige AK3 Proteine) exchange during gastrulation of zebrafish mesoderm.
These results suggest that Ptenb by antagonizing PI3 kinase and its downstream Akt1 and Cdc42 to regulate actin polymerization that is critical for proper cell motility and migration control during gastrulation in zebrafish.
This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery.
The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization.
these data indicate that the ITSN2 exchange factor regulates the activity of Cdc42 during embryo development affecting actin cytoskeleton in Xenopus embryos.
These results demonstrate that to participate in the control of the actin cytoskeleton, RLIP needs its complete N-terminal region coding for the mu2BD and the GAP domain.
Data show that in Xenopus laevis oocytes, polar body emission requires a RhoA (zeige RHOA Proteine) contractile ring and Cdc42-mediated membrane protrusion.
In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure.
Hypoxic pulmonary arterial myocytes challenged with a thromboxane mimetic polymerize actin via the Cdc42 pathway, reflecting increased Cdc42 association with neuronal Wiskott Aldrich Syndrome protein.
Cdc42 is involved in the regulation of alppha-smooth muscle actin promoter activation through p21 (zeige CDKN1A Proteine)-activated kinase, p38 (zeige MAPK14 Proteine), myocardin-related transcription factor and serum response factor. Cdc42 may be an important regulator of MRTF cellular localization
Cdc42 controls protrusion formation in a cell non-autonomous manner.
Cdc42 regulates binding of Crumbs protein to the Par-6 CRIB-PDZ module.
We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development
A proof-of-principle experiment in which the Cdc42 GTPase associates with its alleged partner WASp within neurons during the time and space that coincide with the newly developing CNS.
The distinct buttoning mechanism we propose for dorsal vessel closure is elaborated through signaling pathways regulating Cdc42 activity in this cell type.
there is a mutual dependence between Par proteins and Cdc42 for their localization, regulation of the actin cytoskeleton and, consequently, for the establishment of oocyte polarity
Zir is necessary to activate the Rho-family GTPases Rac2 (zeige RAC2 Proteine) and Cdc42 during the Drosophila cellular immune response.
Results identify the Cdc42/Par6 (zeige PARD6A Proteine)/atypical protein kinase C (zeige PRKCZ Proteine) (aPKC) Par (zeige AFG3L2 Proteine) polarity complex as uniquely and specifically regulating apoptosis-induced compensatory proliferation in Drosophila epithelia.
Wsp activity in within the fly testis is mediated by the small GTPase (zeige RACGAP1 Proteine) Cdc42.
Data demonstrate that Cdc42 and Merlin (zeige NF2 Proteine) act together with Pak1 (zeige PAK1 Proteine) to control salivary gland lumen size.
genetic interactions with CDC42-related genes MSB1, a putative scaffold protein, and RGD3, a putative Rho GTPase-activating protein (GAP) were identified
Rsr1 focuses Cdc42 activity at hyphal tips and promotes maintenance of hyphal development in Candida albicans.
These results suggest the development of hyphal-specific characteristics is promoted by Cdc42-GTP (zeige AK3 Proteine) in a process that also requires the intrinsic GTPase (zeige RACGAP1 Proteine) activity of Cdc42.
The distribution patterns of F-actin were compared to the patterns of Wasp and its putative interaction partners: Wasp and RhoB, but not RhoA or Cdc42, localization overlap with F-actin during capacitation and the acrosome reaction.
results suggest that cell division control protein 42(CDC42) activation is favored by the disruption of the caveolin-1 (zeige CAV1 Proteine)-CDC42 interaction, allowing for its participation in the regulation of capacitation and the acrosome reaction
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
G25K GTP-binding protein
, GTP binding protein, 25kDa
, GTP-binding protein, 25kD
, cell division control protein 42 homolog
, dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
, dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
, growth-regulating protein
, small GTP binding protein CDC42
, cell division cycle 42 homolog
, CDC42 GTP-binding protein
, Cell division control protein 42 homolog
, Cdc42 protein homolog
, cell division cycle 42 (GTP binding protein, 25kDa)
, cell division control protein 42-like protein
, likely rho family Ras-like GTPase
, cell division cycle 42