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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
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1 | ABIN2743473 | ICC IHC (p) WB | Rabbit | IgG | AA 670-858 | Anmelden zum Anzeigen | Polyclonal | 0 | ||
1 | ABIN220767 | ICC WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | ||
1 | ABIN233581 | ICC IP Neut WB | Rabbit | Anmelden zum Anzeigen | Polyclonal | 0 | ||||
1 | ABIN241676 | ICC IHC WB | Rabbit | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | Poly (ADP-Ribose) Polymerase 1 (PARP1) Antikörper |
Epitop | AA 670-858 Alternativen |
Reaktivität | Human, Maus, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser PARP1 Antikörper ist unkonjugiert Alternativen |
Applikation |
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Alternativen
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Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-PARP1 AntikörperTarget Details PARP1 Anwendungsinformationen Handhabung Bilder |
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Verwendungszweck | Rabbit IgG polyclonal antibody for Poly [ADP-ribose] polymerase 1(PARP1) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat. |
Kreuzreaktivität (Details) | No cross reactivity with other proteins. |
Produktmerkmale |
Rabbit IgG polyclonal antibody for Poly [ADP-ribose] polymerase 1(PARP1) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat. Gene Name: poly (ADP-ribose) polymerase 1 Protein Name: Poly [ADP-ribose] polymerase 1 |
Reinigung | Immunogen affinity purified. |
Immunogen | E.coli-derived human PARP recombinant protein (Position: Q670-R858). Human PARP shares 94% and 95% amino acid (aa) sequence identity with mouse and rat PARP, respectively. |
Isotyp | IgG |
Target Details PARP1Produktdetails anti-PARP1 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | PARP1 (PARP1 Antibody Abstract) |
Hintergrund |
Poly [ADP-ribose] polymerase 1 (PARP1), also known as ADPRT or PPOL is an enzyme that in humans is encoded by the PARP1 gene. PARP1 gene is mapped to 1q42.12. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. Synonyms: ADP ribosyltransferase (NAD+, poly (ADP ribose) polymerase) antibody|ADP ribosyltransferase diphtheria toxin like 1 antibody|ADP ribosyltransferase NAD(+) antibody|ADP ribosyltransferase NAD+ antibody|ADPRT 1 antibody|ADPRT antibody|ADPRT1 antibody|ARTD1 antibody|msPARP antibody|NAD(+) ADP ribosyltransferase 1 antibody|NAD(+) ADP-ribosyltransferase 1 antibody|pADPRT 1 antibody|pADPRT1 antibody|PARP 1 antibody|PARP antibody|PARP-1 antibody|PARP1 antibody|PARP1_HUMAN antibody|Poly (ADP ribose) polymerase 1 antibody|poly (ADP ribose) polymerase family, member 1 antibody|Poly [ADP-ribose]polymerase 1 antibody|Poly adenosine diphosphate ADP ribose polymerase antibody|Poly ADP ribose polymerase 1 antibody|Poly ADP ribose polymerase family member 1 antibody|Poly ADP ribose synthetase 1 antibody|Poly(ADP ribose) polymerase antibody|poly(ADP ribose) synthetase antibody|poly(ADP ribosyl)transferase antibody|Poly[ADP ribose] synthetase 1 antibody|Poly[ADP-ribose] synthase 1 antibody|PPOL antibody |
Gen-ID | 142 |
UniProt | P09874 |
Pathways | Apoptose, Caspase Kaskade in der Apoptose, DNA Reparatur, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location |
AnwendungsinformationenProduktdetails anti-PARP1 Antikörper Target Details PARP1 Handhabung Bilder zurück nach oben |
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Applikationshinweise |
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for PARP is approximately 0.25 ng/lane under reducing conditions. IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections. ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. |
Kommentare |
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC. |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-PARP1 Antikörper Target Details PARP1 Anwendungsinformationen Bilder zurück nach oben |
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Format | Lyophilized |
Rekonstitution | Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL. |
Konzentration | 500 μg/mL |
Buffer | Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide. |
Konservierungsmittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freezing and thawing. |
Lagerung | 4 °C/-20 °C |
Informationen zur Lagerung |
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. |
BilderProduktdetails anti-PARP1 Antikörper Target Details PARP1 Anwendungsinformationen Handhabung zurück nach oben |
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Bilder des Herstellers |
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