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Human Caveolin-1 Protein expressed in Wheat germ - ABIN1348146
Kastelijn, van Moorsel, Kazemier, Roothaan, Ruven, Kwakkel-van Erp, van de Graaf, Zanen, van Kessel, Grutters: A genetic polymorphism in the CAV1 gene associates with the development of bronchiolitis obliterans syndrome after lung transplantation. in Fibrogenesis & tissue repair 2011
Show all 4 Pubmed References
These results point to intestinal epithelial cell CAV1 as a potential therapeutic target to lower circulating free fatty acids and LDL cholesterol.
Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration.
The development of transgenic zebrafish lines expressing CLTA (zeige CLTA Proteine) fused to dsRed and CAV1 fused to GFP is reported.
maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin (zeige CTNNB1 Proteine)
These results support important and previously unanticipated roles for the Caveolin-1 isoforms in vertebrate organogenesis.
interactions of cav1 at lipid-exposed domains regulate the partition of the receptor into membrane raft microdomains
These results suggest that the phosphorylated CAV1 functions to activate autophagy through binding to the BECN1 (zeige BECN1 Proteine)/VPS34 (zeige PIK3C3 Proteine) complex under oxidative stress and to protect against ischemic damage.
The effects of ouabain on contractility between WT and cav-1 KO mice were not significantly different.
Nitric oxide promotes caveolin-1-mediated delivery of claudin-5 (zeige CLDN5 Proteine) to the autophagosome for autophagy-lysosome-dependent degradation.
Caveolin-1 phosphorylation on tyrosine 14 may have a role in augmenting melanoma metastasis but not tumorigenesis
Caveolin-1 enhances internalization and degradation of ABCA1 (zeige ABCA1 Proteine) by its association with ABCA1 (zeige ABCA1 Proteine)
cav-1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resista (zeige INS Proteine)nce, cholesterol, and resistin and lower ratios of high- to low-density lipoprotein. cav-1 knockout mice displayed hypertriglyc (zeige INS Proteine)eridemia and higher mRNA (zeige RETN Proteine) levels for resistin, retinol binding protein 4, NADPH oxidase 4, and aldose reductase in liver and/or fat tissues.
we conclude that Cav-1 could play a critical role in preventing nitrative stress-induced liver damage during hepatic ischemia-reperfusion injury
Cav-1 deficiency induces premature senescence via mitochondrial dysfunction and SIRT1 (zeige SIRT1 Proteine) inactivation.
Data show that phosphorylation of caveolin-1 on Tyr (zeige TYR Proteine)(14) in microglia induced the internalization of sodium-vitamin C cotransporter 2 (SVCT2 (zeige SLC23A2 Proteine)).
Caveolin-1 has a role in promoting Ewing sarcoma metastasis regulating MMP-9 (zeige MMP9 Proteine) expression through MAPK/ERK (zeige MAPK1 Proteine) pathway
Stromal, but not tumoural, caveolin-1 expression is significantly associated with survival in Asian women with triple-negative breast cancers.
High CAV1 expression is associated with lung cancer.
Kidney transplant patients with high levels of caveolin-1 immunoreactivity in peritubular capillaries (PTCs) had a significantly worse prognosis than patients with lower levels. CAV-1 immunoreactivity in PTCs was independently associated with graft failure.
CAV-1 knockdown by siRNA causes increased radiosensitivity in basal-like TNBC cells. The mechanisms associated with this effect are reduced DNA repair through delayed CAV-1-associated EGFR (zeige EGFR Proteine) nuclear accumulation and induction of G2/M arrest and apoptosis through the combined effects of CAV-1 siRNA and radiation.
Fluctuation of reactive oxygen species inhibited migration through reducing the interaction between DLC1 (zeige DYNLL1 Proteine) and CAV-1.
We discuss here current knowledge and future approaches to elucidating the molecular mechanisms underlying CAV1 action during hepatocarcinogenesis and evaluate its potential use in clinical therapies.
Disruption of Ankyrin B and Caveolin-1 Interaction Sites Alters Na(+),K(+)-ATPase (zeige ATP1A1 Proteine) Membrane Diffusion
Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer
transcription factor Sp1 (zeige SP1 Proteine) interacts with nucleotides -123/-114, indicating that Sp1 (zeige SP1 Proteine) could play a key role in the transcriptional regulation of pig CAV-1
Two alternative transcript variants encode two isoforms, caveolin-1-alpha and -beta; Cav1 may be implicated in pathogenesis of Glasser's disease of swine.
The plasma membrane Na/K-ATPase (zeige ATP1A1 Proteine)-caveolin-1 interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein (zeige CNBP Proteine) pathway.
The present study indicates that caveolin-containing rafts/caveolins such as caveolin-1 could play a modulating role during oligodendroglial differentiation and regeneration via NGF (zeige NGFB Proteine)/TrkA (zeige NTRK1 Proteine) signaling.
Cav-1 might be a candidate gene for carcass traits, and might provide valuable information for understanding the mechanism of caveolae signaling in fat deposition by using the animal model of pig
Caveolin-1 expression ameliorates nephrotic damage in a rabbit model of cholesterol-induced hypercholesterolemia.
8-Bromo-cAMP stimulated alpha-methyl-D-glucopyranoside uptake via Epac and PKA-dependent SGLTs expression and trafficking through cav-1 and F-actin in proximal tubule cells.
Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt (zeige AKT1 Proteine) signaling
Data show that resveratrol (Res) reversed caveolin-1 (Cav-1)/endothelial nitric oxide synthase (eNOS (zeige NOS3 Proteine)) expressions in high glucose cultured bovine aortic endothelial cells (BAECs).
these data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS (zeige NOS3 Proteine).
Study identifies a critical role of caveolin-1 in the regulation of eNOS (zeige NOS3 Proteine) uncoupling via a biopterin-dependent mechanism.
Data indicate that caveolin-1 expression is required for insulin (zeige INS Proteine) uptake by aortic endothelial cells.
caveolin-1 is not required for the targeting of signaling molecules to caveolae/lipid rafts
integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk (zeige CSK Proteine) association at integrin sites, where it plays a role in downstream, shear-stimulated myelin light chain diphosphorylation.
importance of CAV1 amino acids 89-95 and particularly F92 in mediating eNOS (zeige NOS3 Proteine) inhibition by AP-Cav and Cav-1
When endothelial cells were exposed to shear stress, caveolin-1 was transiently dephosphorylated.
caveolin-1 tyrosine 14 phosphorylation has a role in cell adhesion and migration
results suggest that cell division control protein 42(CDC42 (zeige CDC42 Proteine)) activation is favored by the disruption of the caveolin-1-CDC42 (zeige CDC42 Proteine) interaction, allowing for its participation in the regulation of capacitation and the acrosome reaction
The distribution of CAV-1 is highly dynamic during development and provides new insights into the sorting mechanisms that regulate CAV-1 localization.
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
, caveolin 1
, caveolin, caveolae protein 1
, caveolin, caveolae protein, 22 kDa
, caveolin caveolae protein 22 kDa
, vesicular integral-membrane protein VIP21
, cell growth-inhibiting protein 32
, testis derived transcript