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Human Polyclonal PAFAH1B1 Primary Antibody für ICC, ELISA - ABIN1002740
McManus, Golden: Neuronal migration in developmental disorders. in Journal of child neurology 2005
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Human Polyclonal PAFAH1B1 Primary Antibody für WB - ABIN152366
Green, Wollman, Kaplan: APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. in Molecular biology of the cell 2005
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Human Polyclonal PAFAH1B1 Primary Antibody für IHC (p), IHC - ABIN315651
Lo, Chen, Cheng, Hsu, Wang: Overexpression of PAFAH1B1 is associated with tumor metastasis and poor survival in non-small cell lung cancer. in Lung cancer (Amsterdam, Netherlands) 2012
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Human Polyclonal PAFAH1B1 Primary Antibody für ELISA, WB - ABIN249534
Reiner, Bar-Am, Sapir, Shmueli, Carrozzo, Lindsay, Baldini, Ledbetter, Cahana: LIS2, gene and pseudogene, homologous to LIS1 (lissencephaly 1), located on the short and long arms of chromosome 2. in Genomics 1996
LIS1 promotes dynactin (zeige DCTN1 Antikörper)-dependent tracking of dynein on both growing and shrinking plus ends. LIS1 also increases the frequency and velocity of processive dynein movements that are activated by complex formation with dynactin (zeige DCTN1 Antikörper) and a cargo adaptor.
Microarray analysis after PAFAH1B1 knockdown and its overexpression indicated that the protein maintains Matrix Gla Protein (zeige MGP Antikörper) expression
A novel recurrent LIS1 splice site mutation in classic lissencephaly have been found in two unrelated pediatric patients.
Lis1 has two opposing modes of regulating dynein, being capable of inducing both low and high affinity for the microtubule; study shows that these opposing modes depend on the stoichiometry of Lis1 binding to dynein and that this stoichiometry is regulated by the nucleotide state of dynein's AAA3 domain.
genetic variants in LIS1 may contribute to AML (zeige RUNX1 Antikörper) risk in Chinese population.
Val279Phe gene polymorphisms in PAF-AH (zeige Lp-PLA2 Antikörper) are associated with PAF-AH (zeige Lp-PLA2 Antikörper) activity and PAF (zeige PAF Antikörper) and GMP-140 (zeige SELP Antikörper) levels and may be a risk factor for Henoch-Schonlein purpura with gastrointestinal bleeding
There were no significant associations between R92H and A379V variants of PAF-AH (zeige Lp-PLA2 Antikörper) gene and risk of polycystic ovary syndrome in Chinese women.
results indicate that the NAGK (zeige NAGK Antikörper)-dynein interaction with the involvements of Lis1 and NudE1 plays an important role in prophase nuclear envelope breakdown (NEB (zeige NEB Antikörper)) and metaphase MT-KT attachment during eukaryotic cell division.
Results showed that miR (zeige MLXIP Antikörper)-144 was reduced in cholangiocarcinoma tissues and suggested that miR (zeige MLXIP Antikörper)-144 may be an essential suppresser of cholangiocarcinoma cell proliferation and invasion through targeting LIS1.
LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population.
Nudel (zeige NDEL1 Antikörper)/NudE and Lis1 promote dynein and dynactin (zeige DCTN1 Antikörper) interaction in the context of spindle morphogenesis.
Full rescue by the coiled-coil domain requires LIS1 binding, and increasing LIS1 concentration partly rescues aster formation
PAFAH Ib phospholipase A2 (zeige YWHAZ Antikörper) subunits have distinct roles in maintaining Golgi structure and function.
Results suggest that LIS1 is essential to mediate genomic union in a process that involves the dynein-dynactin (zeige DCTN1 Antikörper) complex.
This study examined the effect of Pafah1b1 overexpression on radial migration of cerebral cortical neurons and found that enhanced expression of Pafah1b1 caused over-migration of neurons into the marginal zone, and Pafah1b1-overexpressing neurons that entered the marginal zone were disoriented.
Lis1 dysfunction reduces migration and traction force production in fibroblasts.
findings suggest that Lis1 is required for germinal center (GC) B (zeige NPR2 Antikörper) cell expansion, affinity maturation, and maintaining functional intact GC response, thus ensuring both the quantity and quality of Ab response
Lis1 plays an important role in T cell homeostasis and the generation of memory T lymphocytes.
This study demonstrated that LIS-1 regulate the septohippocampal cholinergic projection developmental.
Lis1 is required for the expansion of FL-HSCs by ensuring their genomic stability and therefore promoting their survival.
Results show that LIS1 acts via the LIS1-NDEL1 (zeige NDEL1 Antikörper)-dynein complex to regulate astral microtubule MT plus-ends dynamics and establish proper contacts of MTs (zeige NEU2 Antikörper) with the cell cortex to ensure precise cell division.
Conditional deletion of Lis1 in the hematopoietic system led to a severe bloodless phenotype, depletion of the stem cell pool and embryonic lethality.
Rab6a mediates LIS1 release from a LIS1-dynein complex followed by dynein activation.
LIS1 plays prominently in filopodia dynamics and dendritic spine turnover.
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.
, PAF acetylhydrolase 45 kDa subunit
, PAF-AH 45 kDa subunit
, PAF-AH alpha
, PAF-AH beta
, PAFAH alpha
, lissencephaly-1 protein
, platelet-activating factor acetylhydrolase IB subunit alpha
, platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta)
, platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
, platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
, lissencephaly 1 protein
, platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD)
, platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa)
, lissencephaly-1 homolog
, lissencephaly-1 homolog B
, platelet-activating factor acetylhydrolase Ib-alpha subunit
, Miller-Dieker syndrome chromosome region
, Lissencephaly-1 protein
, platelet-activating factor acetylhydrolase isoform Ib alpha subunit
, platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
, platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit