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MAD1 (zeige MXD1 Proteine) and Proto-Oncogene (zeige RAB1A Proteine) Proteins c-myc (zeige MYC Proteine) reciprocally regulate ribosomal DNA transcription, providing a mechanism for coordination of ribosome biogenesis and cell growth
MAD1 (zeige MXD1 Proteine) is present in mouse oocytes at all stages during the first meiosis and that it participates in spindle checkpoint during meiosis
Data show that the loss of Trrap leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap-mediated transcription of the mitotic checkpoint (zeige BUB3 Proteine) proteins Mad1 (zeige MXD1 Proteine) and Mad2 (zeige MXI1 Proteine).
identified mouse Telomeric Repeat Binding Factor 1 (Trf1 (zeige TERF1 Proteine)) as a protein that interacts directly with the spindle checkpoint protein Mad1 (zeige MXD1 Proteine) and the mitotic kinase Nek2 (zeige NEK2 Proteine)
Together these data demonstrate that the MYC (zeige MYC Proteine)-antagonist MAD1 (zeige MXD1 Proteine) and cyclin-dependent kinase inhibitor p27(Kip1 (zeige CDKN1B Proteine)) cooperate to regulate the self-renewal and differentiation of HSCs in a context-dependent manner.
the simultaneous knockdown of p18 (zeige CDKN2C Proteine), p27 (zeige CDKN1B Proteine) and MAD1 (zeige MXD1 Proteine) with a medium of only stem cell factor (zeige KITLG Proteine) can induce long-term culture-initiating cell expansion despite the loss of engraftment ability
Data suggest that LMO7 interacts with MAD1 (zeige MXD1 Proteine) during spindle assembly phase of mitosis; LMO7 plays role in control of mitosis progression and exerts effect on spindle assembly checkpoint; LMO7 colocalizes with actin filaments; LMO7 does not colocalize with MAD1 (zeige MXD1 Proteine) at kinetochores in prometaphase nor at spindle poles in metaphase. (LMO7 = LIM domain only protein-7; MAD1 (zeige MXD1 Proteine) = mitotic spindle assembly checkpoint protein MAD1)
Therefore, Mps1 (zeige IDUA Proteine) promotes checkpoint activation through sequentially phosphorylating Knl1 (zeige CASC5 Proteine), Bub1 (zeige BUB1 Proteine), and Mad1 (zeige MXD1 Proteine). This sequential multi-target phosphorylation cascade makes the checkpoint highly responsive to Mps1 (zeige IDUA Proteine) and to kinetochore-microtubule attachment.
This study showed that MAD1L1 as a susceptibility gene for both of these genetically overlapping disorders is associated with a decreased bottom-up responsiveness of the mesolimbic reward system and related cortical regions involved in the salience network as well as with reduced top-down control processes.
Results show that low DNA methylation (zeige HELLS Proteine) levels of LINC00682, MAD1L1, and LINE-2 was strongly correlated with hepatocellular carcinomas recurrence, patient disease-free survival, and/or overall survival.
MAD1L1 positive expression may be associated with tumour progression and metastasis in small-cell lung cancer (SCLC) and may thus serve as a new biomarker for prognosis in these patients.
In this review, we highlight a novel Mad1 role in chromosome alignment, which is the first conserved mechanism that links the spindle assembly checkpoint and kinesin-mediated chromosome gliding.
MAD1L1 Arg558His and MAD2L1 (zeige MAD2L1 Proteine) Leu84Met interaction with smoking increase the risk of colorectal cancer
MAD1L1 rs12666575 polymorphism may play a protective role against schizophrenia (SCZ) in the Chinese population. rs12666575 may be associated with general psychopathology and thought disturbance in SCZ patients.
We also show that replication perturbations result in relocalization of MAD1 (zeige MXD1 Proteine)/MAD2 (zeige MAD2L1 Proteine) in human cells, suggesting that the role of SAC (zeige ADCY10 Proteine) in DNA repair is conserved.
Mad1 (zeige MXD1 Proteine) has a role in secretion and cell migration.
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.
MAD1-like protein 1
, mitotic arrest deficient 1-like 1
, mitotic arrest deficient 1-like protein 1
, mitotic spindle assembly checkpoint protein MAD1
, mitotic checkpoint MAD1 protein homolog
, mitotic-arrest deficient 1, yeast, homolog-like 1
, tax-binding protein 181
, tumor protein p53 inducible protein 9