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Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 (zeige ANAPC4 Proteine) subunits and does not require UL97-mediated phosphorylation of Cdh1 (zeige CDH1 Proteine).
Studies indicate that APC (zeige APC Proteine)/C(Cdh1 (zeige CDH1 Proteine)) is required to maintain genomic stability.
Results show that Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) element of platelet-derived growth factor 2 mRNA.
APC5 and APC7 (zeige ANAPC7 Proteine) suppress E1A (zeige BCKDHA Proteine)-mediated transformation in a CBP/p300 (zeige CREBBP Proteine)-dependent manner, indicating that these components of the APC (zeige APC Proteine)/C may be targeted during cellular transformation
The anaphase-promoting complex protein 5 (zeige CAPS Proteine) (AnapC5) associates with A20 (zeige TNFAIP3 Proteine) and inhibits IL-17 (zeige IL17A Proteine)-mediated signal transduction.
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
anaphase-promoting complex subunit 5
, cyclosome subunit 5
, anaphase promoting complex subunit 5
, anaphase-promoting complex subunit 5-like
, 20S cyclosome/APC complex protein apc5