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Human Polyclonal ANAPC5 Primary Antibody für IP, WB - ABIN188629
Tran, Kamil, Coen, Spector et al.: Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated ... in Journal of virology 2010
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coexpression of APC5 and Axin (zeige AXIN1 Antikörper) genes significantly downregulated Wnt (zeige WNT2 Antikörper) signaling in human SW480 CRC (zeige CALR Antikörper) cells and inhibited cell growth.
Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 (zeige ANAPC4 Antikörper) subunits and does not require UL97-mediated phosphorylation of Cdh1 (zeige CDH1 Antikörper).
Studies indicate that APC (zeige APC Antikörper)/C(Cdh1 (zeige CDH1 Antikörper)) is required to maintain genomic stability.
Results show that Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) element of platelet-derived growth factor 2 mRNA.
APC5 and APC7 (zeige ANAPC7 Antikörper) suppress E1A (zeige BCKDHA Antikörper)-mediated transformation in a CBP/p300 (zeige CREBBP Antikörper)-dependent manner, indicating that these components of the APC (zeige APC Antikörper)/C may be targeted during cellular transformation
The anaphase-promoting complex protein 5 (zeige CAPS Antikörper) (AnapC5) associates with A20 (zeige TNFAIP3 Antikörper) and inhibits IL-17 (zeige IL17A Antikörper)-mediated signal transduction.
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.
anaphase-promoting complex subunit 5
, cyclosome subunit 5
, anaphase promoting complex subunit 5
, anaphase-promoting complex subunit 5-like
, 20S cyclosome/APC complex protein apc5