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Human Polyclonal AMN Primary Antibody für ICC, IF - ABIN4280385
Galamb, Sipos, Spisák, Galamb, Krenács, Valcz, Tulassay, Molnár et al.: Potential biomarkers of colorectal adenoma-dysplasia-carcinoma progression: mRNA expression profiling and in situ protein detection on TMAs reveal 15 sequentially upregulated and 2 downregulated ... in Cellular oncology : the official journal of the International Society for Cellular Oncology 2008
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heterozygous mutations in AMN (zeige ABCD1 Antikörper) in a family from the United Kingdom with clinical features of Imerslund-Grasbeck Syndrome
Our genetic screening of 154 families of patients with inherited cobalamin malabsorption revealed population-specific mutations, mutational hotspots, and functionally distinct regions in the three causal genes: CUBN (zeige CUBN Antikörper), AMN (zeige ABCD1 Antikörper), and GIF (zeige GIF Antikörper).
amnionless is essential for the correct luminal expression of cubilin (zeige CUBN Antikörper) in humans.
homozygous mutations affecting exons 1-4 of human AMN (zeige ABCD1 Antikörper) lead to megaloblastic anemia 1
cubilin (zeige CUBN Antikörper) and amnionless are subunits of a novel cubilin (zeige CUBN Antikörper)/amnionless (cubam) complex
Recurrent spontaneous abortions may be caused by mutations in the Amnionless gene.
This review summarizes recent data on the biological function of amnionless and focuses on its implication in embryonic nutrition and central nervous system malformations.
AMN (zeige TRAF3 Antikörper) may participate in meiosis in early spermatocytes and in functional differentiation of adult Leydig cells through the mediation of vitamin B(12) transport in the mouse testes
Amn (zeige TRAF3 Antikörper) is an essential component of the Cubn (zeige CUBN Antikörper) receptor complex
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.
, protein amnionless
, visceral endoderm-specific type 1 transmembrane protein
, type I transmembrane protein