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Rat (Rattus) Prothrombin Protein expressed in Rat - ABIN491211
Rancourt, Veress, Ahmad, Hendry-Hofer, Rioux, Garlick, White: Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. in Toxicology and applied pharmacology 2013
this study demonstrated that thrombin and factor Xa cleavage sites on HEV pORF1 are obligatory for HEV replication.
increased frequency of factor V Leiden (zeige F5 Proteine) G1691A and prothrombin G20210A mutation in venous thromboembolism patients indicates a significant role of these mutations in the development of VTE in the Kashmiri population
The results suggest that an increased plasma thrombin potential is characteristic in patients with clinically stable coronary artery disease, irrespective of previous myocardial infarction history and independent of traditional cardiovascular risk factors.
Enhanced thrombin generation is driven in asthma by a systemic inflammatory state mediated by IL-6 (zeige IL6 Proteine) and to a lesser extent TNFalpha (zeige TNF Proteine), however, not periostin (zeige POSTN Proteine). TNFalpha (zeige TNF Proteine) might contribute to impaired fibrinolysis.
Endogenous thrombin potential measured in presence of thrombomodulin (zeige THBD Proteine) is enhanced in patients with intracranial atherosclerotic disease (ICAD (zeige DFFA Proteine)), supporting that thrombomodulin (zeige THBD Proteine)-protein C (zeige PROC Proteine) pathways is relevant in transient ischaemic attacks from ICAD (zeige DFFA Proteine).
PIVKA II, when combined with AFP (zeige AFP Proteine), may be considered as a screening test for hepatocellular carcinoma due to its high negative predictive value.
Thrombin activated platelet releasing exosomes convey miRNA between cells. miRNA-223 regulates the expression of molecules adhesion including ICAM-1 (zeige ICAM1 Proteine). miRNA-223 downregulated ICAM-1 (zeige ICAM1 Proteine) mainly by impacting NF-kappaB (zeige NFKB1 Proteine) and the MAPK (zeige MAPK1 Proteine) pathway.
Thrombin binding to extra-cellular loop II (ECLII) of PAR4 (zeige PAWR Proteine) is important for its cleavage and activation of PAR4 (zeige PAWR Proteine).
These findings suggest that contraction-dependent TGF-beta (zeige TGFB1 Proteine) activation could be a mechanism by which thrombin leads to the development of asthmatic airway remodeling.
Case Report: Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation I prothrombin.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (zeige BGN Proteine) plays a protective role during the progression of atherosclerosis in ApoE (zeige APOE Proteine)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (zeige GP1BA Proteine)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (zeige MARK2 Proteine) interaction regulated MCP-1 (zeige CPT1B Proteine), TF, MCSF (zeige CSF1 Proteine) and IL-6 (zeige IL6 Proteine) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (zeige SERPINC1 Proteine) nanoparticle therapeutics.
Thrombin-PAR1 (zeige F2R Proteine) signaling, via nitric oxide and EPCR (zeige PROCR Proteine), promotes hematopoietic stem cell (HSC (zeige FUT1 Proteine)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (zeige CDC25C Proteine) and Ras-associating domains of phospholipase C epsilon (zeige PLCE1 Proteine).
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (zeige SULF1 Proteine) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (zeige SULF1 Proteine) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (zeige MAPK1 Proteine), MSK1 (zeige RPS6KA5 Proteine), and NF-kappaB (zeige NFKB1 Proteine) play important roles in thrombin-induced iNOS (zeige NOS2 Proteine) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (zeige F2R Proteine)) and thereby increasing the sensitivity of the myofilament to Ca(2 (zeige CA2 Proteine)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (zeige UGDH Proteine) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (zeige F10 Proteine) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (zeige UGDH Proteine) and by receptor-mediated up-regulation of factor XIII (zeige UGDH Proteine) synthesis
In conclusion, thrombin activates pro-MMP-2 (zeige MMP2 Proteine) in the absence of elevated pro-MMP-2 (zeige MMP2 Proteine) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (zeige MMP2 Proteine)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2