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Rat (Rattus) Prothrombin Protein expressed in Rat - ABIN491211
Rancourt, Veress, Ahmad, Hendry-Hofer, Rioux, Garlick, White: Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. in Toxicology and applied pharmacology 2013
Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.
the prothrombotic activity of FII is the result of a polymorphism and of a missense mutation, whereas that of FV derives only from a polymorphism. The observation that a clotting factor (zeige F7 Proteine) defect may be associated with both bleeding or venous thrombosis depending on the site of the mutation has caused an extensive reevaluation of the blood clotting mechanism.
Findings provide evidence for a relationship between two genes-three mutations-of the cardiovascular disease (CVD genes panel and recurrent pregnancy loss (RPL). These genotypes include the heterozygous state of the factor II G20210A mutation.
digestion of thrombin by P. aeruginosa elastase leads to the release of the C-terminal thrombin-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns.
Prothrombin gene mutation is rare in Budd-Chiari syndrome patients in India.
In HBV-related cirrhosis, the combination of miR (zeige MLXIP Proteine)-122, AFP (zeige AFP Proteine) and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
Data, including data using network analysis, suggest that angiotensinogen (AGT (zeige AGT Proteine)), mitogen-activated protein kinase-14 (MAPK14 (zeige MAPK14 Proteine)), and prothrombin (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
Arg596Gln mutation is a risk factor for Chinese patients with venous thromboembolism due to its moderately decreased clotting activity but strong resistance to antithrombin (zeige SERPINC1 Proteine) inhibition.
The induction of TG by BXPC3 cells was mainly driven by the TF pathway while TG generation triggered by MCF7 cells was also driven by FXII (zeige F12 Proteine) activation.
we were not able to confirm the association between the polymorphisms of f5, f2, and mthfr (zeige MTHFR Proteine) and pregnancy loss in Bosnian women
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (zeige BGN Proteine) plays a protective role during the progression of atherosclerosis in ApoE (zeige APOE Proteine)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (zeige GP1BA Proteine)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (zeige MARK2 Proteine) interaction regulated MCP-1 (zeige CPT1B Proteine), TF, MCSF (zeige CSF1 Proteine) and IL-6 (zeige IL6 Proteine) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (zeige SERPINC1 Proteine) nanoparticle therapeutics.
Thrombin-PAR1 (zeige F2R Proteine) signaling, via nitric oxide and EPCR (zeige PROCR Proteine), promotes hematopoietic stem cell (HSC (zeige FUT1 Proteine)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (zeige CDC25C Proteine) and Ras-associating domains of phospholipase C epsilon (zeige PLCE1 Proteine).
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (zeige SULF1 Proteine) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (zeige SULF1 Proteine) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (zeige MAPK1 Proteine), MSK1 (zeige RPS6KA5 Proteine), and NF-kappaB (zeige NFKB1 Proteine) play important roles in thrombin-induced iNOS (zeige NOS2 Proteine) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (zeige F2R Proteine)) and thereby increasing the sensitivity of the myofilament to Ca(2 (zeige CA2 Proteine)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (zeige UGDH Proteine) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (zeige F10 Proteine) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (zeige UGDH Proteine) and by receptor-mediated up-regulation of factor XIII (zeige UGDH Proteine) synthesis
In conclusion, thrombin activates pro-MMP-2 (zeige MMP2 Proteine) in the absence of elevated pro-MMP-2 (zeige MMP2 Proteine) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (zeige MMP2 Proteine)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2