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increased SFRP4 (zeige SFRP4 Proteine) and ficolin-3 levels are significantly associated with gestational diabetes mellitus development and might be important risk factors for this pregnancy complication.
Study found the ratio of ficolin-3/adiponectin at 16-18 weeks of gestation was changed in pregnant women who subsequently developed gestational diabetes mellitus GDM, and might provide effective early predicting and screening for GDM.
Ficolin-3 was overexpressed in the serum of most hepatocellular carcinoma patients after Radiofrequency ablation . Ficolin-3 might be a biomarker for Radiofrequency ablation treatment efficacy and a potential target for hepatocellular carcinoma immunotherapy.
Serum H-ficolin levels inversely correlated with ground-glass opacity score on chest computed tomography in systemic sclerosis-interstitial lung disease (SSc (zeige CYP11A1 Proteine)-ILD) patients. H-ficolin-related innate immunity may be involved in SSc (zeige CYP11A1 Proteine)-ILD development.
Ficolin-3 plasma levels are associated with the presence and progression of abdominal aortic aneurysm (AAA (zeige APP Proteine)), suggesting its potential role as a biomarker of AAA (zeige APP Proteine)
results suggest that anti-ficolin-3 antibodies could be useful for the diagnosis of active nephritis in SLE patients
this study shows that H-ficolin may aid clearance of influenza A virus by promoting monocyte uptake of the virus, while reducing viral replication and virus-induced TNF-a (zeige TNF Proteine) responses in these cells
These results suggest that polymorphisms in the FCN3 gene cooperate to increase ficolin-3 concentration and that it might contribute to leprosy susceptibility by favoring Mycobacterium leprae infection.
subjects that were heterozygote carriers of both FCN2 (zeige FCN2 Proteine) + 6424 and FCN3 + 1637delC were sufficient mannan-binding lectin (zeige MBL2 Proteine) producers
in patients with systemic lupus erythematosus, there was no significant association between ficolin-1 (zeige FCN1 Proteine) and ficolin-3 with lupus nephritis
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
, collagen/fibrinogen domain-containing lectin 3 p35
, collagen/fibrinogen domain-containing protein 3
, ficolin 3