FCN2 Proteine (FCN2)

Bezeichnung:
Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) Proteine (FCN2)
Auf www.antikoerper-online.de finden Sie aktuell 9 Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FCN2 Antikörper (68) und FCN2 Kits (20) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 101 FCN2 Produkte verfügbar.
Synonyme:
EBP-37, Fcn2, FCNB, FCNL, ficolin-2, P35
alle Proteine anzeigen Gen GeneID UniProt
FCN2 2220 Q15485
FCN2 14134 O70497
FCN2 114091 P57756

Weitere Synonyme anzeigen

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Human Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2) Interaktionspartner

  1. The results suggest that the Arctic populations of East Siberia are characterised by specificity of genetic make-up responsible for the activity of L-ficolin.

  2. study provides evidence for an important role for the lectin pathway in the inflammatory response induced by cholesterol crystals (CC) and emphasize the role of ficolin-2 and MBL in the CC-mediated inflammation occurring during atherosclerotic plaque development

  3. FCN2 inhibits epithelial-mesenchymal transition-induced metastasis of hepatocellular carcinoma via TGF-beta1 (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) signaling.

  4. this study shows that FCN2 polymorphisms is not a major risk factor for community-acquired pneumonia in general, but that the +6424G>T SNP in the FCN2 gene predisposes to Coxiella burnetii pneumonia

  5. subjects that were heterozygote carriers of both FCN2 + 6424 and FCN3 (zeige FCN3 Proteine) + 1637delC were sufficient mannan-binding lectin (zeige MBL2 Proteine) producers

  6. systemic lupus erythematosus patients with low plasma ficolin-2 levels had an increased risk of having lupus nephritis

  7. Ficolin-2 protein could bind with HIV-1 envelope glycoprotein (zeige ERVW-1 Proteine) gp120 (zeige ITIH4 Proteine), and subsequently induce complement dependent cytotoxicity.

  8. The FCN2 c.772G>T genotype appears to be associated with predisposition to chronic adenotonsillitis in the pediatric age group.

  9. Serum levels of ficolin-2 and ficolin-3 (zeige FCN3 Proteine) were significantly lower in the cardiac syndrome X patients compared to controls.

  10. association of FCN2 polymorphisms with nephritis and severe cumulative damage in SLE patients; no association with rheumatoid arthritis development

Mouse (Murine) Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2) Interaktionspartner

  1. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans.

  2. Data show that ficolin-B is stored in and set free from immature granulocytic myeloid cells indicating a role in the early infection-induced cellular response of these inflammatory cells.

  3. FcnA-deficient and FcnA/ficolin B double-deficient mice lack FcnA-mediated complement activation in the sera, because of absence of complexes comprising FcnA and MBL-associated serine proteases.

  4. These results identify mouse ficolin-B as a functional member of the ficolin family activating complement via the lectin pathway.

  5. Results show that ficolin B in mouse bone marrow is an oligomeric protein. Ficolin B contained very low, but detectable, amounts of MASP-2 and sMAP and showed detectable C4-deposition activity on immobilized N-acetylglucosamine.

  6. Ficolin B exhibited a distinct ontogeny pattern that switched from embryonic liver to postnatal bone marrow and spleen. The cells that express ficolin B mRNA were identified as belonging to the myeloid cell lineage.

  7. Ficolin B showed multimeric structures and revealed binding to both N-acetylglucosamine and N-acetylgalactosamine. Ficolin B specifically recognized sialic acid residues. Ficolin B plays a distinct role through its unique carbohydrate-binding specificity.

FCN2 Protein Überblick

Protein Überblick

The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with FCN2

  • ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) (FCN2)
  • ficolin (collagen/fibrinogen domain containing) 1 (FCN1)
  • ficolin B (Fcnb)
  • EBP-37 Protein
  • Fcn2 Protein
  • FCNB Protein
  • FCNL Protein
  • ficolin-2 Protein
  • P35 Protein

Bezeichner auf Proteinebene für FCN2

ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) , ficolin 2 , 37 kDa elastin-binding protein , L-ficolin , collagen/fibrinogen domain-containing protein 2 , ficolin B , ficolin-2 , ficolin-B , ficolin-beta , serum lectin p35

GENE ID SPEZIES
473087 Pan troglodytes
2220 Homo sapiens
396881 Sus scrofa
497016 Bos taurus
14134 Mus musculus
114091 Rattus norvegicus
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