C1R Proteine (C1R)

Bezeichnung:
Complement Component 1, R Subcomponent Proteine (C1R)
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Synonyme:
C1R, c1rl, MGC84776, MGC127774
alle Proteine anzeigen Gen GeneID UniProt
C1R 715 P00736
Ratte C1R C1R 312705  

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Weitere Proteine zu C1R Interaktionspartnern

Human Complement Component 1, R Subcomponent (C1R) Interaktionspartner

  1. We identified a novel, homozygous, loss-of-function mutation (p.Pro445Leufs*11) in the C1R gene. Using the Sanger method of DNA sequencing in 14 family members, we confirmed the presence of the mutation in 4 patients with early-onset systemic lupus erythematosus and in an asymptomatic 9-year-old girl. Complement levels were low in sera from patients with truncated C1r protein.

  2. Periodontal Ehlers-Danlos Syndrome in at least the great majority of cases results from specific classes of heterozygous mutations in C1R and C1S (zeige C1S Proteine).

  3. We confirmed increased levels of C1R and VTN (zeige VTN Proteine) in sera from patients with Joint hypermobility syndrome by western blot analyses

  4. C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r/C1s (zeige C1S Proteine) proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin (zeige NCL Proteine) and nucleophosmin 1 (zeige NPM1 Proteine). T

  5. C1r specificity is well suited to its cleavage targets and that efficient cleavage of C1s (zeige C1S Proteine) is achieved through both active site and exosite contributions.

  6. Analysis of its interaction properties by surface plasmon resonance shows that rC1q retains the ability of serum C1q to associate with the C1s (zeige C1S Proteine)-C1r-C1r-C1s (zeige C1S Proteine) tetramer, to recognize physiological C1q ligands such as IgG and pentraxin 3 (zeige PTX3 Proteine)

  7. a structural rearrangement as a switch between functional states of human C1r

  8. These results provide further structural insights into the architecture of the C1 complex, and the interactions between C1r and C1s (zeige C1S Proteine).

  9. The modular C1r protein is the first protease activated in the classical complement pathway, a key component of innate immunity.

  10. Detailed mapping of C1q post-translational modifications and insights into the C1r/C1s (zeige C1S Proteine) binding sites.

C1R Protein Überblick

Protein Überblick

C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.

Alternative names and synonyms associated with C1R

  • complement component 1, r subcomponent (C1R)
  • complement component 1, r subcomponent (C1r)
  • complement component 1, r subcomponent (c1r)
  • C1R Protein
  • c1rl Protein
  • MGC84776 Protein
  • MGC127774 Protein

Bezeichner auf Proteinebene für C1R

complement C1r subcomponent , complement C1r , complement component 1, r subcomponent , complement component 1 subcomponent r

GENE ID SPEZIES
715 Homo sapiens
445464 Sus scrofa
312705 Rattus norvegicus
418295 Gallus gallus
444745 Xenopus laevis
466939 Pan troglodytes
477707 Canis lupus familiaris
511581 Bos taurus
613057 Xenopus (Silurana) tropicalis
100549554 Meleagris gallopavo
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