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TGFBR3 ELISA Kit

TGFBR3 Reaktivität: Human Colorimetric Sandwich ELISA 156 pg/mL - 10000 pg/mL Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
Produktnummer ABIN6719731
  • Target Alle TGFBR3 ELISA Kits anzeigen
    TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))
    Reaktivität
    • 3
    • 2
    • 1
    • 1
    Human
    Nachweismethode
    Colorimetric
    Methodentyp
    Sandwich ELISA
    Detektionsbereich
    156 pg/mL - 10000 pg/mL
    Untere Nachweisgrenze
    156 pg/mL
    Applikation
    ELISA
    Verwendungszweck
    Sandwich ELISA for Quantitative Detection of Antigen
    Proben
    Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
    Analytische Methode
    Quantitative
    Produktmerkmale

    Synonyms: Beta glycan, Betaglycan, Betaglycan proteoglycan, BGCAN, TGBR3_HUMAN, TGF beta receptor type 3, TGF beta receptor type III, TGF-beta receptor type 3, TGF-beta receptor type III, TGFB R3, TGFBR 3, TGFBR3, TGFR 3, TGFR-3, TGFR3, Transforming growth factor beta receptor III, Transforming growth factor beta receptor III betaglycan 300 kDa, Transforming growth factor beta receptor type 3

    Background: Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell- surfacechondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors. By cDNA array and immunohistochemistry analyses, it is found that TGFBR3 expression is lost in most breast cancers examined in association with loss of heterozygosity of the TGFBR3 locus. TGFBR3 expression decreased during breast cancer progression, and low levels predicted decreased recurrence-free survival in patients. Loss of TGFBR3 through allelic imbalance is a frequent genetic event during breast cancer development that increases metastatic potential. Also, TGFBR3 can localize transformation in the heart and play an essential, nonredundant role in TGF-beta signaling.

    Gene Name: TGFBR3

    Production: Natural and recombinant human TGFBR3. There is no detectable cross-reactivity with other relevant proteins.

    Standard: Expression system for standard: NSO, Immunogen sequence: G21-D781

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  • Applikationshinweise

    Application Note: Useful in Sandwich ELISA for Quantitative Detection of Antigen. Aliquot 0.1 mL per well of the 10,000pg/mL, 5000pg/mL, 2500pg/mL, 1250pg/mL, 625pg/mL, 312pg/mL, 156pg/mL human TGFBR3 standard solutions into the precoated 96-well plate. Add 0.1 mL of the sample diluent buffer into the control well (Zero well). Add 0.1 mL of each properly diluted sample of human cell culture supernates, serum or plasma(heparin , EDTA) to each empty well. It is recommended that each human TGFBR3 standard solution and each sample be measured in duplicate.

    Blood Product Anticoagulant: Heparin Sodium

    ELISA Dilution: 156pg/mL-10,000pg/mL

    Probenmenge
    100 μL
    Plattentyp
    Pre-coated
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Lagerung
    RT,4 °C,-20 °C
    Informationen zur Lagerung
    Store vials at 4°C prior to opening. Centrifuge product if not completely clear after standing at room temperature. This product is stable for 6 months at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage freeze at -20°C or below for 12 months. Avoid cycles of freezing and thawing.
  • Target Alle TGFBR3 ELISA Kits anzeigen
    TGFBR3 (Transforming Growth Factor, beta Receptor III (TGFBR3))
    Andere Bezeichnung
    TGFBR3 (TGFBR3 Produkte)
    Synonyme
    TGFBR3 ELISA Kit, DKFZp469I0915 ELISA Kit, BGCAN ELISA Kit, betaglycan ELISA Kit, 1110036H20Rik ELISA Kit, AU015626 ELISA Kit, AW215636 ELISA Kit, TBRIII ELISA Kit, transforming growth factor beta receptor 3 ELISA Kit, transforming growth factor, beta receptor III ELISA Kit, TGFBR3 ELISA Kit, tgfbr3 ELISA Kit, Tgfbr3 ELISA Kit
    Gen-ID
    7049
    NCBI Accession
    NP_001182612
    UniProt
    Q03167
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