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New ELAVL1 (zeige ELAVL1 Proteine)-TYK2 fusion gene is oncogenic in acute myeloid leukemia (zeige BCL11A Proteine).
TYK2 gene variants do not seem to play an important role in Chagas disease susceptibility and/or chronic Chagas cardiomyopathy
TYK2 polymorphism is not associated with Dermatomyositis /Polymyositis in the Chinese Han population
TYK2 activating mutants and fusion proteins were detected in patients diagnosed with leukaemic diseases suggesting that TYK2 is a potent oncogene (zeige RAB1A Proteine).
TYK2 genetic variants are differentially associated with common autoimmune diseases
High TYK2 expression is associated with B-cell lymphoma.
These data indicate that germline activating TYK2 mutations predispose to the development of ALL.
TYK2 rs280519 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
TYK2 is associated with systemic sclerosis susceptibility and reinforce the relevance of the IL-12 (zeige IL12A Proteine) pathway in SSc (zeige CYP11A1 Proteine) pathophysiology.
Clinical genomic analysis of the current series of NF1 (zeige NF1 Proteine)-MPNST cases found that TYK2 is a new gene mutated in MPNST.
Results show that loss of TYK2 does not affect disease severity of JAK2VF-induced murine myeloproliferative neoplasms (MPN (zeige PRSS27 Proteine)) indicating that TYK2 has no cooperative effects with JAK2VF at the onset of MPN (zeige PRSS27 Proteine).
mutated form which lacks tyrosine kinase (zeige TYRO3 Proteine) activity restores differentiation of brown preadipocytes
Decreased Tyk2 expression in pancreatic beta cells due to mutation determines susceptibility to virus-induced diabetes mellitus.
Tyk2 protects against acute colitis in part by amplifying inflammation-induced epithelial IL-22 (zeige IL22 Proteine) signaling to STAT3 (zeige STAT3 Proteine)
A reduced survival fitness of the Th17 in the absence of Tyk-2 mediated by the up-regulation of SOCS3 (zeige SOCS3 Proteine).
Data indicate the important role of Tyk2 in skin inflammation and the therapeutic potential of Tyk2 inhibition in psoriasis.
The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer.
In cellular assays, SAR (zeige SRL Proteine)-20347 dose dependently (1 nM-10 muM) inhibited JAK1 (zeige JAK1 Proteine)- and/or TYK2-dependent signaling from the IL-12 (zeige IL12A Proteine)/IL-23 (zeige IL23A Proteine), IL-22 (zeige IL22 Proteine), and IFN-alpha (zeige IFNA Proteine) receptors.
this report identifies Tyk2 as a prerequisite factor in the molecular networks that are involved in generation of IL-27 (zeige IL27 Proteine).
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
non-receptor tyrosine-protein kinase TYK2
, tyrosine kinase TYK2
, non-receptor tyrosine kinase Tyk2