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IL-4 (zeige IL4 Proteine)-STAT6 signaling pathway establishes an alternative polarization-specific epigenenomic signature resulting in dampened macrophage responsiveness to inflammatory stimuli
IL-4Delta2 did not compete with IL-4 (zeige IL4 Proteine) for IL-4Ralpha binding and did not interfere with the downstream STAT-6 phosphorylation in T cells.
Histamine and Stat6 have roles in differentiation of macrophages from CD11b (zeige ITGAM Proteine)(+) myeloid cells and formation of foam cells
IL-4Ralpha deficiency inhibited the activation of STAT6 in the mouse kidneys in two experimental models of renal fibrosis. . In vitro, IL-4 (zeige IL4 Proteine) activated STAT6 and stimulated expression of alpha-smooth muscle actin (zeige ACTG2 Proteine) and fibronectin (zeige FN1 Proteine) in mouse bone marrow monocytes.
a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 (zeige ADRB3 Proteine) stimulation with Foxp3 (zeige FOXP3 Proteine)(+) Treg induction and adipose tissue function.
these findings show that Stat6 has an oncogenic role in intestinal tumorigenesis by promoting polyp cell proliferation and immunosuppressive mediators, and preventing an active cytotoxic process.
STAT6 facilitated atherosclerotic plaque stabilization by promoting the polarization of macrophages to M2 subtype and antagonizing ox-LDL-induced cell apoptosis and lipid deposition in a Wnt (zeige WNT2 Proteine)-beta-catenin (zeige CTNNB1 Proteine)-dependent manner.
Colorectal carcinoma cells induce M2 polarization of tumor-associated macrophagess through MFHAS1 induction and subsequent STAT6 and KLF4 (zeige KLF4 Proteine) activation to promote CRC progression.
Our results demonstrate that STAT6 is critical in the early steps of colitis-associated colon cancer (CAC (zeige SLC25A20 Proteine)) development for modulating inflammatory responses and controlling cell recruitment and proliferation. Thus, STAT6 may represent a promising target for CAC (zeige SLC25A20 Proteine) treatment.
Gefitinib effectively inhibits tumor-associated macrophage M2-like polarization both in vitro and in vivo by targeting the STAT6 signaling pathway.
Inhibition of STAT6/Anoctamin-1 (zeige ANO1 Proteine) activation decreased proliferation, migration, or invasion of gastric cancer cells.
Results of our structure-function studies on STAT6 shed light on mechanism of DNA recognition by STATs in general and explain the reasons underlying STAT6's preference for N4 site DNA over N3.
There was no significant relationship between rs324011 and rs3024974 SNPs and psoriasis in the present study or in other studies, indicating that STAT6 is not a candidate gene for psoriasis susceptibility
these results showed that allergy responses further accelerated the IL-4 (zeige IL4 Proteine)-induced inhibition of tumor development through the activation of STAT6 pathways.
In this study, significant lower level of miR (zeige MLXIP Proteine)-214-3p and higher level of STAT6 in the intestinal mucosa of active UC patients compared with the health controls were confirmed by quantitative real-time PCR.
IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells
Our finding supports that STAT3 (zeige STAT3 Proteine) was the potential treated target for breast cancer therapy, whereas STAT5A (zeige STAT5A Proteine)/5B/6 were potential prognostic markers for better survival of BC, providing more accurate prognosis.
N4 DNA recognition by STAT6: structural and functional implications.
Data suggest that STAT6 and RANKL (zeige TNFSF11 Proteine) are involved in regulation of apoptosis, gene expression, and cell proliferation in hepatocellular carcinoma cell lines; depletion of STAT6 using RNA interference increases apoptosis; this mechanism involves down-regulation of expression of RANKL (zeige TNFSF11 Proteine). (STAT6 = signal transducer and activator of transcription 6; RANKL (zeige TNFSF11 Proteine) = receptor activator of nuclear factor kappa B ligand (zeige TNFSF11 Proteine))
The results showed that SARS (zeige SARS Proteine) coronavirus papain-like protease (PLPro) stimulated TGF-beta1 (zeige TGFB1 Proteine)-dependent expression of Type I collagen via activating STAT6 pathway.
this study shows that weaning caused severe inflammation associated with the suppression of STAT6 in the jejunum of piglets
Data show that IL-4 (zeige IL4 Proteine) induces upregulation of the junction protein claudin-5 (zeige CLDN5 Proteine) in endothelial cells (ECs) through activation of Jak (zeige JAK3 Proteine)/STAT6 and phosphorylation and translocation of FoxO1 (zeige FOXO1 Proteine) from the nucleus to the cytoplasm.
Results provide evidence that polymorphisms in STAT6 are associated with carcass and growth efficiency traits
IL-4 (zeige IL4 Proteine) and STAT6 are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
signal transducer and transcription activator 6
, STAT, interleukin4-induced
, signal transducer and activator of transcription 6
, transcription factor IL-4 STAT