anti-Affe STAT2 Antikörper für Western Blotting

Recommended STAT2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antikörper
  • wu:fj84d07
  • p113
  • stat2
  • 1600010G07Rik
  • AW496480
  • ISGF-3
  • P113
  • STAT113
  • signal transducer and activator of transcription 2
  • AGAP000099-PA
  • stat2
  • STAT2
  • Stat2
Epitop
C-Term, pSer734
48
34
19
17
15
15
13
11
11
9
8
7
7
7
5
5
5
4
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Affe
267
100
83
9
3
3
2
2
2
2
1
Wirt
Kaninchen
290
18
1
Klonalität
Polyklonal
Konjugat
Dieser STAT2 Antikörper ist unkonjugiert
12
10
9
6
6
6
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
252
119
110
47
27
25
18
13
9
6
4
3
3
2
1
1
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen

Bilder

Produktnummer ABIN5596752
$ 598.50
Zzgl. Versandkosten $45.00 und $22.60 Trockeneis
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
7.727556 ABIN2705257 IHC WB Rabbit C-Term, pTyr690 Anmelden zum Anzeigen Polyclonal 0
7.727556 ABIN2972201 IHC WB KLH Rabbit IgG C-Term, pTyr690 Anmelden zum Anzeigen Polyclonal 0
7.727556 ABIN2972501 IHC WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN3198330 IHC WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN2628802 WB Rabbit IgG AA 796-814 Anmelden zum Anzeigen Polyclonal 0
1 ABIN602339 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2744561 IHC IHC (p) WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN1938666 IP WB Rabbit IgG AA 801-851 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2628796 ELISA WB Rabbit pSer734 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Antikörper
Epitop C-Term, pSer734
(48), (34), (19), (17), (15), (15), (13), (11), (11), (9), (8), (7), (7), (7), (5), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Affe
(267), (100), (83), (9), (3), (3), (2), (2), (2), (2), (1)
Wirt Kaninchen
(290), (18), (1)
Klonalität
Polyklonal
Konjugat Dieser STAT2 Antikörper ist unkonjugiert
(12), (10), (9), (6), (6), (6), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Applikation ELISA, Western Blotting (WB)
(252), (119), (110), (47), (27), (25), (18), (13), (9), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-STAT2 Antikörper

Target Details STAT2 Anwendungsinformationen Handhabung Bilder
Kreuzreaktivität (Details) This antibody is specific for phosphorylated S734 human STAT2. A BLAST analysis was used to suggest cross-reactivity with STAT2 pS734 protein from human and monkey sources based on homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
Reinigung STAT2 pS734 affinity purified antibody is directed against human STAT2 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
Immunogen

Immunogen: STAT2 pS734 antibody was prepared from whole rabbit serum produced by repeated immunizations with a phosphorylated synthetic peptide corresponding to serine 734 a region near the C-terminus of human STAT2 protein.

Immunogen Type: Peptide

Isotyp IgG
Plasmids, Primers & others

Target Details STAT2

Produktdetails anti-STAT2 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung STAT2 (STAT2 Antibody Abstract)
Hintergrund

Synonyms: Signal transducer and activator of transcription 2, p113, STAT2 antibody

Background: STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. STAT2 pS734 antibody is ideal for researchers focused in cancer and transcripton factor research.

Gene Name: STAT2

UniProt P52630
Pathways JAK-STAT Signalweg, Hepatitis C, CXCR4-mediated Signaling Events

Anwendungsinformationen

Produktdetails anti-STAT2 Antikörper Target Details STAT2 Handhabung Bilder zurück nach oben
Applikations-hinweise

Application Note: Anti-STAT2 pS734 antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 97.9 kDa in size corresponding to STAT2pS734 protein by western blotting in the appropriate cell lysate or extract.

Western Blot Dilution: 1:1,000

ELISA Dilution: 1:5,000

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-STAT2 Antikörper Target Details STAT2 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 0.64 mg/mL
Buffer

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Haltbarkeit 12 months

Bilder

Produktdetails anti-STAT2 Antikörper Target Details STAT2 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (C-Term), (pSer734) antibody (ABIN5596752) Western Blot of Rabbit anti-STAT2pS734 antibody. Lane 1: U6A cells (STAT2 deficient) ...