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PVT1 interacts with STAT1 to inhibit IFN-alpha (zeige IFNA Proteine) signaling and tumor cells proliferation.
STAT1 is associated with giant cell tumor of bone recurrence, which might serve as biomarker for giant cell tumor of bone recurrence
High STAT1 expression is associated with head and neck squamous cell carcinoma.
The research described here specifies where in the JAK (zeige JAK3 Proteine)/STAT signaling cascade the IFN response is inhibited and which protein domain of nsP2 (zeige RTN2 Proteine) is responsible for IFN inhibition. The results illuminate new aspects of antiviral defense and CHIKV counterdefense strategies and will direct the search for novel antiviral compounds.
These results reveal that STAT1 pS727 regulates growth and differentiation in JAK (zeige JAK3 Proteine)-STAT activated neoplasms and suggest that Mediator kinase inhibition represents a therapeutic strategy to regulate JAK (zeige JAK3 Proteine)-STAT signaling
Transcription factor STAT1 regulates the expression of LINC00174
Dysregulation of the IFN-gamma (zeige IFNG Proteine)-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia
STAT1b plays a key role in enhancing the tumor suppressor function of STAT1a, in ESCC, in a manner that can be amplified by IFN-gamma (zeige IFNG Proteine)
HSP90 (zeige HSP90 Proteine) is an upstream regulator of the ACK1 (zeige TNK2 Proteine)-dependent phosphorylation of STAT1 and STAT3 (zeige STAT3 Proteine).
These findings suggest that IFN-a (zeige IFNA6 Proteine) can inhibit HCV replication through a STAT2 (zeige STAT2 Proteine)-dependent but STAT1-independent pathway, whereas IFN-g (zeige IFNG Proteine) induces ISG expression and inhibits HCV replication exclusively through a STAT1- and STAT2 (zeige STAT2 Proteine)-dependent pathway.
Downregulated SOCS1 (zeige SOCS1 Proteine) expression activates the JAK1 (zeige JAK1 Proteine)/STAT1 pathway and promotes polarization of macrophages into M1 type.
The Lipopolysaccharide and IFN-beta (zeige IFNB1 Proteine)-mediated increase of STAT1 mRNA and protein levels was abrogated by chelation of Zn(2+) with the membrane permeable chelator N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) in RAW 264.7 macrophages.
The possibility that the Gas6 (zeige GAS6 Proteine)-Mer (zeige ERH Proteine)-PI3K/Akt (zeige AKT1 Proteine)-STAT1-LXR (zeige NR1H3 Proteine)-Arg2 (zeige ARG2 Proteine) pathway plays an essential role for resolving inflammatory response in acute lung injury.
The results of this study strongly indicated that release of interferons by neuronal cells expressing polyglutamine-TBP (zeige TBP Proteine) leads to induction of STAT1 and consequent downregulation of miR (zeige MLXIP Proteine)-29a/b by a series of cell signaling events.
STAT1 is required to protect B cell development during murine norovirus infection.
Rigidity plays a key role in the toxicity of multi-walled carbon nanotubes and results in increased inflammatory, immunologic, and fibrogenic effects in the lung. STAT1 is an important protective factor in the fibroproliferative response to rMWCNTs, regulating both induced TGF-beta1 (zeige TGFB1 Proteine) production and Smad2 (zeige SMAD2 Proteine)/3 phosphorylation status.
these results confirmed that myricitrin exhibited anti-inflammatory activity by blocking the activation of JAKs and the downstream transcription factor STAT1, which may result from the downregulation of NOX2 (zeige CYBB Proteine)-dependent ROS (zeige ROS1 Proteine) production mediated by myricitrin.
Data suggest that histone acetylation drives elevated Stat1/Myd88 (zeige MYD88 Proteine) expression in macrophages from mice with type 1 diabetes; this mechanism is exhibited in both peritoneal macrophages and bone marrow-differentiated macrophages. (Stat1 = signal transducer and activator of transcription 1; Myd88 (zeige MYD88 Proteine) = myeloid differentiation primary response gene 88 (zeige MYD88 Proteine))
the role of unphosphorylated STAT1 differs from that of P-STAT1, and represses apoptosis in macrophages to promote immune evasion during Mycobacterium tuberculosis infection.
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (zeige IFNA Proteine) response by inducing STAT1 degradation.
this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (zeige JAK3 Proteine)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (zeige STAT2 Proteine) nuclear translocation.
Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1/STAT2 (zeige STAT2 Proteine) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (zeige GHRL Proteine) on ovarian cell functions.
the majority of the STAT1/STAT2 (zeige STAT2 Proteine)/IRF9 (zeige IRF9 Proteine) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (zeige CASP8 Proteine) mRNA levels is associated with phosphorylation of STAT-1 at Ser (zeige SIGLEC1 Proteine)-727 and STAT1 binding to the caspase-8 (zeige CASP8 Proteine) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
Report interferon-tau dependent STAT1 regulation of SOCS (zeige CISH Proteine) genes in bovine endometrium during estrus cycle and embryo implantation.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (zeige IL6 Proteine) (IL), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1/STAT3 (zeige STAT3 Proteine) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (zeige CSN2 Proteine) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (zeige STAT2 Proteine).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 1
, signal transducer and activator of transcription 4
, transcription factor ISGF-3
, activator of transcription
, signal transduction
, LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta
, signal transducer and activator of transcription 1, 91kDa