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Data show that RNF2 (zeige RNF2 Proteine) promotes STAT1/STAT2 (zeige STAT2 Proteine) disassociation from DNA.
In lipotoxic hepatocytes, MLK3 activates a MAPK (zeige MAPK1 Proteine) signaling cascade, resulting in the activating phosphorylation of STAT1, and CXCL10 (zeige CXCL10 Proteine) transcriptional upregulation.
our data indicate that luteolin diminishes the proinflammatory mediators NO, inflammatory cytokines and the expression of their regulatory genes, iNOS (zeige NOS2 Proteine) and COX-2, in PRV-infected RAW264.7 cells by inhibiting STAT1/3 dependent NF-kappaB (zeige NFKB1 Proteine) activation and inducing Nrf2mediated HO-1 (zeige HMOX1 Proteine) expression.
Results showed that the mRNA expression of STAT1 increased during the early stage of adipogenesis under the regulation of Bcl6 (zeige BCL6 Proteine).
Angiotensin II regulates dendritic cells through activation of p65 NF-kappaB (zeige NFkBP65 Proteine), ERK1 (zeige MAPK3 Proteine), ERK2 (zeige MAPK1 Proteine) and STAT1 pathways.
The results provide functional evidence that elevated PDGFRbeta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 pathway is a crucial modulator of this phenotypic spectrum.
selective knockdown of TNFR5 ameliorates glucolipotoxic induction of STAT1 expression and NF-kappaB (zeige NFKB1 Proteine) activity.
Treatment of the haplotype Npr1 (zeige NPR1 Proteine)(+/-) mice with histone deacetylase (zeige HDAC1 Proteine) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (zeige HDAC1 Proteine)/2, NF-kappaB (zeige NFKB1 Proteine) (p65 (zeige NFkBP65 Proteine)), and STAT1.
PHLPP1 reduced IFN-gamma (zeige IFNG Proteine)-stimulated but not LPS (zeige TLR4 Proteine)-induced ERK1/2 phosphorylation, and inhibition of ERK1/2 abolished IFN-gamma-induced (zeige SAMHD1 Proteine) ser (zeige SIGLEC1 Proteine)(727) STAT1 phosphorylation and iNOS (zeige NOS2 Proteine) expression.
Data demonstrate that STAT1 is a key orchestrator of cytokine-producing innate lymphoid cells responses during viral infection via ILC (zeige CCL27 Proteine)-extrinsic regulation of IL-33 (zeige IL33 Proteine) and IL-23 (zeige IL23A Proteine).
The results of the present study indicate that ISTP may inhibit TARC/CCL17 (zeige CCL17 Proteine) production in human epidermal keratinocytes via the STAT1 signaling pathway and may be associated with the inhibition of IL33 (zeige IL33 Proteine) production.
In human gastrointestinal stromal tumors (GIST) cell lines, treatment with imatinib abrogated the IFNgamma-induced upregulation of PD-L1 (zeige CD274 Proteine) via STAT1 inhibition. PD-1 (zeige PDCD1 Proteine)/PD-L1 (zeige CD274 Proteine) blockade is a promising strategy to improve the effects of targeted therapy in GISTs
STAT3 (zeige STAT3 Proteine)/STAT1 ratios are better clinical predictors in colorectal carcinoma as compared to STAT3 (zeige STAT3 Proteine) or STAT1 levels alone.
In a subgroup of Schizophrenic patients, blood levels of STAT1 were significantly higher compared to the control group.
Suggest a positive feedback mechanism via the STAT1/3 pathway sustains cytokine production and reveal a reciprocal regulatory role of JAK (zeige JAK3 Proteine)/STAT in TNFalpha (zeige TNF Proteine)-mediated senescence.
our findings suggested that OSM (zeige OSM Proteine) suppresses SLUG expression and tumor metastasis of lung adenocarcinoma cells through inducing the inhibitory effect of the STAT1-dependent pathway and suppressing the activating effect of STAT3 (zeige STAT3 Proteine)-dependent signaling
miR (zeige MLXIP Proteine)-2909 could play a vital role in prostate carcinogenesis through modulation of ISGylation system and TGFbeta (zeige TGFB1 Proteine) signalling via STAT1/SOCS3 (zeige SOCS3 Proteine).
The phosphorylation of STAT1 promotes its binding to TRADD (zeige TRADD Proteine), and thus recruits Fas (zeige FAS Proteine)-associated protein with DD (FADD (zeige FADD Proteine)) and caspase 8 (zeige CASP8 Proteine) to form DISC complexes.
The results demonstrate that cystatin B (zeige CSTB Proteine) interferes with the STAT-1 signaling and IFN-beta (zeige IFNB1 Proteine)-antiviral responses perpetuating HIV in macrophage reservoirs.
propose that one molecule of C protein associates with the STAT1:STAT2 (zeige STAT2 Proteine) heterodimer, inducing a conformational change to an antiparallel form, which is easily dephosphorylated
Collectively, these data show that porcine epidemic diarrhea virus is capable of subverting the type I interferon (zeige IFNA Proteine) response by inducing STAT1 degradation.
this study shows that weaning caused severe inflammation associated with the suppression of STAT1 in the jejunum of piglets
Data indicate that transmissible gastroenteritis virus (TGEV) infection activates the janus kinase signal transducer and activator of the transcription 1 (JAK (zeige JAK3 Proteine)-STAT1) signaling pathway.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 (zeige STAT2 Proteine) nuclear translocation.
Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1/STAT2 (zeige STAT2 Proteine) signal transduction by inducing karyopherin-alpha1 degradation.
STAT1 is involved in mediating the action of ghrelin (zeige GHRL Proteine) on ovarian cell functions.
the majority of the STAT1/STAT2 (zeige STAT2 Proteine)/IRF9 (zeige IRF9 Proteine) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Cell-type-specific expression of STAT1 highlight the complex interplay between endometrium and conceptus for pregnancy recognition and implantation.
Nitric oxide-dependent increase in caspase-8 (zeige CASP8 Proteine) mRNA levels is associated with phosphorylation of STAT-1 at Ser (zeige SIGLEC1 Proteine)-727 and STAT1 binding to the caspase-8 (zeige CASP8 Proteine) promoter in cultured lung endothelial cells.
Activated STAT1 may be associated with or perhaps contribute to the structural and inflammatory changes in pacing-induced sustained atrial fibrillation.
Report interferon-tau dependent STAT1 regulation of SOCS (zeige CISH Proteine) genes in bovine endometrium during estrus cycle and embryo implantation.
the interaction between STAT1 SNP and SNP19069 was highly significant for survival rate
results show for the first time that interleukin-6 (zeige IL6 Proteine) (IL), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1/STAT3 (zeige STAT3 Proteine) proteins in bovine articular chondrocytes
Results from this study are consistent with previous studies on the role of STAT1 in regulating the transcription of genes involved in milk protein (zeige CSN2 Proteine) synthesis and fat metabolism.
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 and, to a lesser extent, STAT2 (zeige STAT2 Proteine).
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 1-alpha/beta
, HAI-2 related small protein
, signal transducer and activator of transcription-1
, transcription factor ISGF-3 components p91/p84
, signal transducer and activator of transcription 4
, signal transducer and activator of transcription 1
, transcription factor ISGF-3
, activator of transcription
, signal transduction